Evaluation of microvascular changes in the perifoveal vascular network using optical coherence tomography angiography (OCTA) in type I diabetes mellitus: a large scale prospective trial
Abstract Background Diabetic retinopathy (DR) is the leading cause of blindness in type 1 Diabetes Mellitus (DM) patients, as a consequence of impaired blood flow in the retina. Optical coherence tomography angiography (OCTA) is a newly developed, non-invasive, retinal imaging technique that permits...
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | BMC Medical Imaging |
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| Online Access: | http://link.springer.com/article/10.1186/s12880-019-0391-8 |
| _version_ | 1819227701004730368 |
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| author | Javier Zarranz-Ventura Marina Barraso Anibal Alé-Chilet Teresa Hernandez Cristian Oliva Jesus Gascón Anna Sala-Puigdollers Marc Figueras-Roca Irene Vinagre Emilio Ortega Enric Esmatjes Alfredo Adan |
| author_facet | Javier Zarranz-Ventura Marina Barraso Anibal Alé-Chilet Teresa Hernandez Cristian Oliva Jesus Gascón Anna Sala-Puigdollers Marc Figueras-Roca Irene Vinagre Emilio Ortega Enric Esmatjes Alfredo Adan |
| author_sort | Javier Zarranz-Ventura |
| collection | DOAJ |
| description | Abstract Background Diabetic retinopathy (DR) is the leading cause of blindness in type 1 Diabetes Mellitus (DM) patients, as a consequence of impaired blood flow in the retina. Optical coherence tomography angiography (OCTA) is a newly developed, non-invasive, retinal imaging technique that permits adequate delineation of the perifoveal vascular network. It allows the detection of paramacular areas of capillary non perfusion and/or enlargement of the foveal avascular zone (FAZ), representing an excellent tool for assessment of DR. The relationship of these microvascular changes with systemic factors such as metabolic control or duration of the disease still needs to be elucidated. Methods Prospective, consecutive, large-scale OCTA study. A complete ocular examination including a comprehensive series of OCTA images of different scan sizes captured with 2 OCT devices (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA, USA, and Triton Deep Range Imaging OCT, Topcon Corp, Topcon, Japan) will be obtained as part of the yearly routine follow up visits in type 1 DM patients seen in the Diabetes Unit of the Endocrinology department which give written informed consent to participate in the project. The aim of this study is to investigate the relationship between OCTA-derived parameters and systemic factors, as metabolic control (Hb1Ac, lipid profile, cholesterol, etc), and other relevant clinical factors as demographics or duration of the disease. Discussion This study is directed to investigate the relationship between the status of the perifoveal vascular network and systemic markers of the disease, and in particular to study whether these changes reflect those occurring elsewhere in the body affected by diabetic microvascular disease, as the kidneys or the brain. If these relationships were demonstrated, early detection of these microvascular changes by OCTA could lead to modifications in the pharmacological management of type 1 diabetic patients, as a way to reduce the risk of future complications in both the eye and other organs. Trial registration ClinicalTrials.gov, trial number NCT03422965. |
| first_indexed | 2024-12-23T10:45:34Z |
| format | Article |
| id | doaj.art-b39d5b3f66914adf9aed5915850ffd27 |
| institution | Directory Open Access Journal |
| issn | 1471-2342 |
| language | English |
| last_indexed | 2024-12-23T10:45:34Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj.art-b39d5b3f66914adf9aed5915850ffd272022-12-21T17:50:03ZengBMCBMC Medical Imaging1471-23422019-11-011911610.1186/s12880-019-0391-8Evaluation of microvascular changes in the perifoveal vascular network using optical coherence tomography angiography (OCTA) in type I diabetes mellitus: a large scale prospective trialJavier Zarranz-Ventura0Marina Barraso1Anibal Alé-Chilet2Teresa Hernandez3Cristian Oliva4Jesus Gascón5Anna Sala-Puigdollers6Marc Figueras-Roca7Irene Vinagre8Emilio Ortega9Enric Esmatjes10Alfredo Adan11Institut Clínic d’Oftalmología (ICOF), Hospital Clinic de BarcelonaInstitut Clínic d’Oftalmología (ICOF), Hospital Clinic de BarcelonaInstitut Clínic d’Oftalmología (ICOF), Hospital Clinic de BarcelonaInstitut Clínic d’Oftalmología (ICOF), Hospital Clinic de BarcelonaInstitut Clínic d’Oftalmología (ICOF), Hospital Clinic de BarcelonaInstitut Clínic d’Oftalmología (ICOF), Hospital Clinic de BarcelonaInstitut Clínic d’Oftalmología (ICOF), Hospital Clinic de BarcelonaInstitut Clínic d’Oftalmología (ICOF), Hospital Clinic de BarcelonaDiabetes Unit, Institut Clínic de Malalties Digestives i Metaboliques (ICMDM), Hospital Clinic de BarcelonaInstitut D’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Institut D’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)Institut Clínic d’Oftalmología (ICOF), Hospital Clinic de BarcelonaAbstract Background Diabetic retinopathy (DR) is the leading cause of blindness in type 1 Diabetes Mellitus (DM) patients, as a consequence of impaired blood flow in the retina. Optical coherence tomography angiography (OCTA) is a newly developed, non-invasive, retinal imaging technique that permits adequate delineation of the perifoveal vascular network. It allows the detection of paramacular areas of capillary non perfusion and/or enlargement of the foveal avascular zone (FAZ), representing an excellent tool for assessment of DR. The relationship of these microvascular changes with systemic factors such as metabolic control or duration of the disease still needs to be elucidated. Methods Prospective, consecutive, large-scale OCTA study. A complete ocular examination including a comprehensive series of OCTA images of different scan sizes captured with 2 OCT devices (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA, USA, and Triton Deep Range Imaging OCT, Topcon Corp, Topcon, Japan) will be obtained as part of the yearly routine follow up visits in type 1 DM patients seen in the Diabetes Unit of the Endocrinology department which give written informed consent to participate in the project. The aim of this study is to investigate the relationship between OCTA-derived parameters and systemic factors, as metabolic control (Hb1Ac, lipid profile, cholesterol, etc), and other relevant clinical factors as demographics or duration of the disease. Discussion This study is directed to investigate the relationship between the status of the perifoveal vascular network and systemic markers of the disease, and in particular to study whether these changes reflect those occurring elsewhere in the body affected by diabetic microvascular disease, as the kidneys or the brain. If these relationships were demonstrated, early detection of these microvascular changes by OCTA could lead to modifications in the pharmacological management of type 1 diabetic patients, as a way to reduce the risk of future complications in both the eye and other organs. Trial registration ClinicalTrials.gov, trial number NCT03422965.http://link.springer.com/article/10.1186/s12880-019-0391-8FoveaMaculaDiabetes mellitusType 1 Diabetes mellitusDiabetic retinopathyVascular network |
| spellingShingle | Javier Zarranz-Ventura Marina Barraso Anibal Alé-Chilet Teresa Hernandez Cristian Oliva Jesus Gascón Anna Sala-Puigdollers Marc Figueras-Roca Irene Vinagre Emilio Ortega Enric Esmatjes Alfredo Adan Evaluation of microvascular changes in the perifoveal vascular network using optical coherence tomography angiography (OCTA) in type I diabetes mellitus: a large scale prospective trial BMC Medical Imaging Fovea Macula Diabetes mellitus Type 1 Diabetes mellitus Diabetic retinopathy Vascular network |
| title | Evaluation of microvascular changes in the perifoveal vascular network using optical coherence tomography angiography (OCTA) in type I diabetes mellitus: a large scale prospective trial |
| title_full | Evaluation of microvascular changes in the perifoveal vascular network using optical coherence tomography angiography (OCTA) in type I diabetes mellitus: a large scale prospective trial |
| title_fullStr | Evaluation of microvascular changes in the perifoveal vascular network using optical coherence tomography angiography (OCTA) in type I diabetes mellitus: a large scale prospective trial |
| title_full_unstemmed | Evaluation of microvascular changes in the perifoveal vascular network using optical coherence tomography angiography (OCTA) in type I diabetes mellitus: a large scale prospective trial |
| title_short | Evaluation of microvascular changes in the perifoveal vascular network using optical coherence tomography angiography (OCTA) in type I diabetes mellitus: a large scale prospective trial |
| title_sort | evaluation of microvascular changes in the perifoveal vascular network using optical coherence tomography angiography octa in type i diabetes mellitus a large scale prospective trial |
| topic | Fovea Macula Diabetes mellitus Type 1 Diabetes mellitus Diabetic retinopathy Vascular network |
| url | http://link.springer.com/article/10.1186/s12880-019-0391-8 |
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