<i>DNMT3B</i> rs2424913 as a Risk Factor for Congenital Heart Defects in Down Syndrome

<i>DNMT3B</i> rs2424913 as a Risk Factor for Congenital Heart Defects in Down Syndrome

Impairments of the genes that encode enzymes that are involved in one-carbon metabolism because of the presence of gene polymorphisms can affect the methylation pattern. The altered methylation profiles of the genes involved in cardiogenesis may result in congenital heart defects (CHDs). The aim of...

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Bibliographic Details
Main Authors: Dijana Majstorović, Anita Barišić, Ivana Babić Božović, Iva Bilić Čače, Neven Čače, Mauro Štifanić, Jadranka Vraneković
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Genes
Subjects:
congenital heart defect
DNA methyltransferase
Down syndrome
<i>MTHFR</i>
<i>MTRR</i>
single-nucleotide polymorphism
Online Access:https://www.mdpi.com/2073-4425/14/3/576

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