Reduced phosphorus is associated with older age and hypoalbuminemia. Risk factors for all-cause mortality in peritoneal dialysis patients
Introduction/aimHyperphosphatemia is a mortality risk factor in dialysis patients; however, low phosphorus levels too. Diabetes and malnutrition are strongly associated with mortality and with reduced serum phosphorus. This study analyzed the pattern of serum phosphorus in patients on Peritoneal Dia...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1094256/full |
| _version_ | 1797782982915784704 |
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| author | Marcela Ávila Ma. del Carmen Prado Miguel Ángel Cuevas-Budhart Ramón Paniagua |
| author_facet | Marcela Ávila Ma. del Carmen Prado Miguel Ángel Cuevas-Budhart Ramón Paniagua |
| author_sort | Marcela Ávila |
| collection | DOAJ |
| description | Introduction/aimHyperphosphatemia is a mortality risk factor in dialysis patients; however, low phosphorus levels too. Diabetes and malnutrition are strongly associated with mortality and with reduced serum phosphorus. This study analyzed the pattern of serum phosphorus in patients on Peritoneal Dialysis (PD) and its association with mortality.MethodsA Secondary analysis was performed on a multicenter cohort study in peritoneal dialysis patients from two previous studies done by our group.ResultsSix hundred fifty-four patients were included. Serum phosphorus was <3.6 mg/dL in 28.29% of patients, 3.6 to 5.2 mg/dL in 48.16%, and >5.2 mg/dL in 23.55%. In logistic regression analysis; education, age, and hypoalbuminemia were risk factors for low P levels. In multivariate Cox analysis P < 3.6 mg/dL, age, and low albumin were predictors for all-cause mortality. When lower P and lower albumin were combined, this group had the highest risk for all cause and cardiovascular mortality.ConclusionThe frequency of patients with reduced serum phosphorus was higher in the Mexican population than in Europe or Asia. Low serum phosphorus levels, older age and hypoalbuminemia were risk factors for all-cause mortality. Low phosphorus combined with low albumin levels were the highest risk factor for all-cause and cardiovascular mortality. |
| first_indexed | 2024-03-13T00:19:39Z |
| format | Article |
| id | doaj.art-b39f0e0291364201bdd9f05bd354eeb6 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-13T00:19:39Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-b39f0e0291364201bdd9f05bd354eeb62023-07-11T16:48:54ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-07-011010.3389/fnut.2023.10942561094256Reduced phosphorus is associated with older age and hypoalbuminemia. Risk factors for all-cause mortality in peritoneal dialysis patientsMarcela ÁvilaMa. del Carmen PradoMiguel Ángel Cuevas-BudhartRamón PaniaguaIntroduction/aimHyperphosphatemia is a mortality risk factor in dialysis patients; however, low phosphorus levels too. Diabetes and malnutrition are strongly associated with mortality and with reduced serum phosphorus. This study analyzed the pattern of serum phosphorus in patients on Peritoneal Dialysis (PD) and its association with mortality.MethodsA Secondary analysis was performed on a multicenter cohort study in peritoneal dialysis patients from two previous studies done by our group.ResultsSix hundred fifty-four patients were included. Serum phosphorus was <3.6 mg/dL in 28.29% of patients, 3.6 to 5.2 mg/dL in 48.16%, and >5.2 mg/dL in 23.55%. In logistic regression analysis; education, age, and hypoalbuminemia were risk factors for low P levels. In multivariate Cox analysis P < 3.6 mg/dL, age, and low albumin were predictors for all-cause mortality. When lower P and lower albumin were combined, this group had the highest risk for all cause and cardiovascular mortality.ConclusionThe frequency of patients with reduced serum phosphorus was higher in the Mexican population than in Europe or Asia. Low serum phosphorus levels, older age and hypoalbuminemia were risk factors for all-cause mortality. Low phosphorus combined with low albumin levels were the highest risk factor for all-cause and cardiovascular mortality.https://www.frontiersin.org/articles/10.3389/fnut.2023.1094256/fullreduced phosphoruslow serum phosphorusall-cause mortalitycardiovascular mortalitymalnutritionperitoneal dialysis |
| spellingShingle | Marcela Ávila Ma. del Carmen Prado Miguel Ángel Cuevas-Budhart Ramón Paniagua Reduced phosphorus is associated with older age and hypoalbuminemia. Risk factors for all-cause mortality in peritoneal dialysis patients Frontiers in Nutrition reduced phosphorus low serum phosphorus all-cause mortality cardiovascular mortality malnutrition peritoneal dialysis |
| title | Reduced phosphorus is associated with older age and hypoalbuminemia. Risk factors for all-cause mortality in peritoneal dialysis patients |
| title_full | Reduced phosphorus is associated with older age and hypoalbuminemia. Risk factors for all-cause mortality in peritoneal dialysis patients |
| title_fullStr | Reduced phosphorus is associated with older age and hypoalbuminemia. Risk factors for all-cause mortality in peritoneal dialysis patients |
| title_full_unstemmed | Reduced phosphorus is associated with older age and hypoalbuminemia. Risk factors for all-cause mortality in peritoneal dialysis patients |
| title_short | Reduced phosphorus is associated with older age and hypoalbuminemia. Risk factors for all-cause mortality in peritoneal dialysis patients |
| title_sort | reduced phosphorus is associated with older age and hypoalbuminemia risk factors for all cause mortality in peritoneal dialysis patients |
| topic | reduced phosphorus low serum phosphorus all-cause mortality cardiovascular mortality malnutrition peritoneal dialysis |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1094256/full |
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