Frequency-Dependent Effects on Bladder Reflex by Saphenous Nerve Stimulation and a Possible Action Mechanism of Tibial Nerve Stimulation in Cats
Purpose The present study determined the effects of saphenous nerve stimulation (SNS) at different stimulation frequencies on bladder reflex and explored a possible action mechanism of tibial nerve stimulation (TNS) on bladder activity in cats. Methods Two bipolar nerve cuff electrodes were implante...
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| Format: | Article |
| Language: | English |
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Korean Continence Society
2021-06-01
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| Series: | International Neurourology Journal |
| Subjects: | |
| Online Access: | http://www.einj.org/upload/pdf/inj-2040304-152.pdf |
| _version_ | 1818435733627600896 |
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| author | Xing Li Xiaoping Wan Zhaoxia Wang Yanan Liang Zhuo Jia Xu Zhang Limin Liao |
| author_facet | Xing Li Xiaoping Wan Zhaoxia Wang Yanan Liang Zhuo Jia Xu Zhang Limin Liao |
| author_sort | Xing Li |
| collection | DOAJ |
| description | Purpose The present study determined the effects of saphenous nerve stimulation (SNS) at different stimulation frequencies on bladder reflex and explored a possible action mechanism of tibial nerve stimulation (TNS) on bladder activity in cats. Methods Two bipolar nerve cuff electrodes were implanted on the saphenous nerve and the contralateral tibial nerve in 13 cats, respectively. Multiple cystometrograms were obtained to determine the effects of single SNS at different frequencies and that of combined SNS and TNS on the micturition reflex by infusing normal saline. Results SNS at 1 Hz significantly reduced the bladder capacity (BC) to 59.8%±7.7% and 59.3%±5.8% of the control level at the intensity threshold (T) and 2T, respectively (P<0.05), while that at 20 Hz significantly increased the BC to 130.6%±4.2% of the control level at 6T (P<0.05). The TNS and SNS at 20 Hz did not significantly change the BCs at 1T (P>0.05), while combined stimulation at 1T significantly increased the BC to 122.7%±1.9% of the control level and induced an inhibitory effect which was similar to that TNS at 2T. Conclusions The current study revealed that SNS reduced and increased BC depending on different stimulation frequencies. The combined SNS and TNS maximized the clinical efficacy at a low intensity. Also, SNS may be a potential therapeutic mechanism of TNS. |
| first_indexed | 2024-12-14T16:57:35Z |
| format | Article |
| id | doaj.art-b3a0496b10c14f7195cb883e497053f1 |
| institution | Directory Open Access Journal |
| issn | 2093-4777 2093-6931 |
| language | English |
| last_indexed | 2024-12-14T16:57:35Z |
| publishDate | 2021-06-01 |
| publisher | Korean Continence Society |
| record_format | Article |
| series | International Neurourology Journal |
| spelling | doaj.art-b3a0496b10c14f7195cb883e497053f12022-12-21T22:53:55ZengKorean Continence SocietyInternational Neurourology Journal2093-47772093-69312021-06-0125212813610.5213/inj.2040304.152925Frequency-Dependent Effects on Bladder Reflex by Saphenous Nerve Stimulation and a Possible Action Mechanism of Tibial Nerve Stimulation in CatsXing Li0Xiaoping Wan1Zhaoxia Wang2Yanan Liang3Zhuo Jia4Xu Zhang5Limin Liao6 Department of Urology, Medical College of People’s Liberation Army, Chinese People’s Liberation Army General Hospital, Beijing, China Department of Urology, Rehabilitation School of Capital Medical University, China Rehabilitation Research Center, Beijing, China Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Department of Urology, Rehabilitation School of Capital Medical University, China Rehabilitation Research Center, Beijing, China Department of Urology, Medical College of People’s Liberation Army, Chinese People’s Liberation Army General Hospital, Beijing, China Department of Urology, Medical College of People’s Liberation Army, Chinese People’s Liberation Army General Hospital, Beijing, China Department of Urology, Rehabilitation School of Capital Medical University, China Rehabilitation Research Center, Beijing, ChinaPurpose The present study determined the effects of saphenous nerve stimulation (SNS) at different stimulation frequencies on bladder reflex and explored a possible action mechanism of tibial nerve stimulation (TNS) on bladder activity in cats. Methods Two bipolar nerve cuff electrodes were implanted on the saphenous nerve and the contralateral tibial nerve in 13 cats, respectively. Multiple cystometrograms were obtained to determine the effects of single SNS at different frequencies and that of combined SNS and TNS on the micturition reflex by infusing normal saline. Results SNS at 1 Hz significantly reduced the bladder capacity (BC) to 59.8%±7.7% and 59.3%±5.8% of the control level at the intensity threshold (T) and 2T, respectively (P<0.05), while that at 20 Hz significantly increased the BC to 130.6%±4.2% of the control level at 6T (P<0.05). The TNS and SNS at 20 Hz did not significantly change the BCs at 1T (P>0.05), while combined stimulation at 1T significantly increased the BC to 122.7%±1.9% of the control level and induced an inhibitory effect which was similar to that TNS at 2T. Conclusions The current study revealed that SNS reduced and increased BC depending on different stimulation frequencies. The combined SNS and TNS maximized the clinical efficacy at a low intensity. Also, SNS may be a potential therapeutic mechanism of TNS.http://www.einj.org/upload/pdf/inj-2040304-152.pdfurinary bladder, overactivesaphenous nervetibial nerve stimulationurinary bladder, underactive |
| spellingShingle | Xing Li Xiaoping Wan Zhaoxia Wang Yanan Liang Zhuo Jia Xu Zhang Limin Liao Frequency-Dependent Effects on Bladder Reflex by Saphenous Nerve Stimulation and a Possible Action Mechanism of Tibial Nerve Stimulation in Cats International Neurourology Journal urinary bladder, overactive saphenous nerve tibial nerve stimulation urinary bladder, underactive |
| title | Frequency-Dependent Effects on Bladder Reflex by Saphenous Nerve Stimulation and a Possible Action Mechanism of Tibial Nerve Stimulation in Cats |
| title_full | Frequency-Dependent Effects on Bladder Reflex by Saphenous Nerve Stimulation and a Possible Action Mechanism of Tibial Nerve Stimulation in Cats |
| title_fullStr | Frequency-Dependent Effects on Bladder Reflex by Saphenous Nerve Stimulation and a Possible Action Mechanism of Tibial Nerve Stimulation in Cats |
| title_full_unstemmed | Frequency-Dependent Effects on Bladder Reflex by Saphenous Nerve Stimulation and a Possible Action Mechanism of Tibial Nerve Stimulation in Cats |
| title_short | Frequency-Dependent Effects on Bladder Reflex by Saphenous Nerve Stimulation and a Possible Action Mechanism of Tibial Nerve Stimulation in Cats |
| title_sort | frequency dependent effects on bladder reflex by saphenous nerve stimulation and a possible action mechanism of tibial nerve stimulation in cats |
| topic | urinary bladder, overactive saphenous nerve tibial nerve stimulation urinary bladder, underactive |
| url | http://www.einj.org/upload/pdf/inj-2040304-152.pdf |
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