SIRT7, H3K18ac, and ELK4 Immunohistochemical Expression in Hepatocellular Carcinoma

SIRT7, H3K18ac, and ELK4 Immunohistochemical Expression in Hepatocellular Carcinoma

Background SIRT7 is one of the histone deacetylases and is NAD-dependent. It forms a complex with ETS-like transcription factor 4 (ELK4), which deacetylates H3K18ac and works as a transcriptional suppressor. Overexpression of SIRT7 and deacetylation of H3K18ac have been shown to be associated with a...

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Bibliographic Details
Main Authors: Hye Seung Lee, Wonkyung Jung, Eunjung Lee, Hyeyoon Chang, Jin Hyuk Choi, Han Gyeom Kim, Aeree Kim, Baek-hui Kim
Format: Article
Language:English
Published: Korean Society of Pathologists & the Korean Society for Cytopathology 2016-09-01
Series:Journal of Pathology and Translational Medicine
Subjects:
Carcinoma, hepatocellular
ELK4
Sirtuin 7 protein
H3K18ac
Immunohistochemistry
Online Access:http://www.jpatholtm.org/upload/pdf/jptm-2016-05-20.pdf

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