Spatially and temporally resolved metabolome of the human oral cavity
Summary: Saliva is a complex bodily fluid composed of secretions by major and minor salivary glands. Salivary glands and their secretions are known to be unevenly distributed in the human oral cavity. Moreover, saliva flow rate and composition vary across locations and time of the day. This remarkab...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224001056 |
| _version_ | 1797341233867128832 |
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| author | Alessio Ciurli Yassene Mohammed Christine Ammon Rico J.E. Derks Damien Olivier-Jimenez Quinten R. Ducarmon Marije Slingerland Jacques Neefjes Martin Giera |
| author_facet | Alessio Ciurli Yassene Mohammed Christine Ammon Rico J.E. Derks Damien Olivier-Jimenez Quinten R. Ducarmon Marije Slingerland Jacques Neefjes Martin Giera |
| author_sort | Alessio Ciurli |
| collection | DOAJ |
| description | Summary: Saliva is a complex bodily fluid composed of secretions by major and minor salivary glands. Salivary glands and their secretions are known to be unevenly distributed in the human oral cavity. Moreover, saliva flow rate and composition vary across locations and time of the day. This remarkable heterogeneity of salivary secretions suggests that different subtypes of saliva fulfill different functions. By coupling a non-invasive and facile collection method with comprehensive metabolomic profiling, we investigated the spatial and temporal distributions of salivary components. We identified location-specific metabolite profiles, novel oscillating metabolites, and location-specific diurnal patterns. In summary, our study paves the way for a deeper and more comprehensive understanding of the complex dynamics and functionalities of the salivary metabolome and its integration in multi-omics studies related to oral and systemic (patho-)physiology. |
| first_indexed | 2024-03-08T10:14:53Z |
| format | Article |
| id | doaj.art-b3a4b4b6f4ca4069981542cafed3309b |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-08T10:14:53Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-b3a4b4b6f4ca4069981542cafed3309b2024-01-29T04:16:16ZengElsevieriScience2589-00422024-02-01272108884Spatially and temporally resolved metabolome of the human oral cavityAlessio Ciurli0Yassene Mohammed1Christine Ammon2Rico J.E. Derks3Damien Olivier-Jimenez4Quinten R. Ducarmon5Marije Slingerland6Jacques Neefjes7Martin Giera8Oncode Institute and Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, the NetherlandsCenter for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, the NetherlandsCenter for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, the NetherlandsCenter for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, the NetherlandsCenter for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, the NetherlandsStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany; Department of Medical Microbiology, Leiden University Medical Center, 2333 ZA Leiden, the NetherlandsDepartment of Medical Oncology, Leiden University Medical Center, 2333 ZA Leiden, the NetherlandsOncode Institute and Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, the NetherlandsCenter for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands; Corresponding authorSummary: Saliva is a complex bodily fluid composed of secretions by major and minor salivary glands. Salivary glands and their secretions are known to be unevenly distributed in the human oral cavity. Moreover, saliva flow rate and composition vary across locations and time of the day. This remarkable heterogeneity of salivary secretions suggests that different subtypes of saliva fulfill different functions. By coupling a non-invasive and facile collection method with comprehensive metabolomic profiling, we investigated the spatial and temporal distributions of salivary components. We identified location-specific metabolite profiles, novel oscillating metabolites, and location-specific diurnal patterns. In summary, our study paves the way for a deeper and more comprehensive understanding of the complex dynamics and functionalities of the salivary metabolome and its integration in multi-omics studies related to oral and systemic (patho-)physiology.http://www.sciencedirect.com/science/article/pii/S2589004224001056Oral medicineBiomoleculesBiological constraintsMetabolomics |
| spellingShingle | Alessio Ciurli Yassene Mohammed Christine Ammon Rico J.E. Derks Damien Olivier-Jimenez Quinten R. Ducarmon Marije Slingerland Jacques Neefjes Martin Giera Spatially and temporally resolved metabolome of the human oral cavity iScience Oral medicine Biomolecules Biological constraints Metabolomics |
| title | Spatially and temporally resolved metabolome of the human oral cavity |
| title_full | Spatially and temporally resolved metabolome of the human oral cavity |
| title_fullStr | Spatially and temporally resolved metabolome of the human oral cavity |
| title_full_unstemmed | Spatially and temporally resolved metabolome of the human oral cavity |
| title_short | Spatially and temporally resolved metabolome of the human oral cavity |
| title_sort | spatially and temporally resolved metabolome of the human oral cavity |
| topic | Oral medicine Biomolecules Biological constraints Metabolomics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224001056 |
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