Epicardial Fat Thickness and Bone Mineral Content: The Healthy Twin Study in Korea
Background: The conventional concept of positive association between general obesity and bone health was challenged in recent studies reporting the different effects of specific fat deposition on bone health. In the present study, we investigated the association between epicardial fat and bone healt...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Japan Epidemiological Association
2018-05-01
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| Series: | Journal of Epidemiology |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jea/28/5/28_JE20170027/_pdf |
| _version_ | 1818032849121443840 |
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| author | Dong-won Lee Min Soo Cho Eun Yeong Choe Seung Woo Park Yun-Mi Song Sang-Chol Lee Joohon Sung |
| author_facet | Dong-won Lee Min Soo Cho Eun Yeong Choe Seung Woo Park Yun-Mi Song Sang-Chol Lee Joohon Sung |
| author_sort | Dong-won Lee |
| collection | DOAJ |
| description | Background: The conventional concept of positive association between general obesity and bone health was challenged in recent studies reporting the different effects of specific fat deposition on bone health. In the present study, we investigated the association between epicardial fat and bone health. Methods: We measured echocardiographic epicardial fat thickness (EFT) and bone mineral content (BMC) in a twin-family cohort of Koreans (n = 1,198; 525 men, 460 pre- and 213 post-menopausal women). A total 121 pairs of monozygotic twin (MZ) and 404 pairs of dizygotic twin and sibling pairs (DZ/Sib) were included. Results: EFT was positively associated with BMC in total, as well as in three subgroups (β = 0.107, 0.076, and 0.058 for men, pre-, and post-menopausal women, respectively). The positive association between EFT and BMC remained for DZ/Sib difference analysis, but was absent for MZ comparisons. The positive association between BMI and BMC was consistent for DZ/Sib and MZ difference analysis. After adjusting for the effect of general obesity via BMI, the association between BMC and EFT was statistically non-significant (β = 0.020, 0.000, and −0.009 for men, pre-, and post-menopausal women, respectively). Conclusion: Our findings do not support epicardial fat’s beneficial effects on bone health, whereas general adiposity has an osteotropic effect. The association between EFT and BMC is through common genetic component factors. |
| first_indexed | 2024-12-10T06:13:54Z |
| format | Article |
| id | doaj.art-b3a4cec04e324c238f12ab0b053cfe5a |
| institution | Directory Open Access Journal |
| issn | 0917-5040 1349-9092 |
| language | English |
| last_indexed | 2024-12-10T06:13:54Z |
| publishDate | 2018-05-01 |
| publisher | Japan Epidemiological Association |
| record_format | Article |
| series | Journal of Epidemiology |
| spelling | doaj.art-b3a4cec04e324c238f12ab0b053cfe5a2022-12-22T01:59:29ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922018-05-0128525325910.2188/jea.JE20170027Epicardial Fat Thickness and Bone Mineral Content: The Healthy Twin Study in KoreaDong-won Lee0Min Soo Cho1Eun Yeong Choe2Seung Woo Park3Yun-Mi Song4Sang-Chol Lee5Joohon Sung6Department of Internal Medicine, Division of Gastroenterology, Korea University Ansan Hospital, Ansan, KoreaHeart Institute, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Division of Endocrinology, Yonsei University College of Medicine, Seoul, KoreaDepartment of Cardiology and Cardiovascular Imaging Center, Cardiac and Vascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Cardiology and Cardiovascular Imaging Center, Cardiac and Vascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Epidemiology, School of Public Health, Seoul National University, Seoul, KoreaBackground: The conventional concept of positive association between general obesity and bone health was challenged in recent studies reporting the different effects of specific fat deposition on bone health. In the present study, we investigated the association between epicardial fat and bone health. Methods: We measured echocardiographic epicardial fat thickness (EFT) and bone mineral content (BMC) in a twin-family cohort of Koreans (n = 1,198; 525 men, 460 pre- and 213 post-menopausal women). A total 121 pairs of monozygotic twin (MZ) and 404 pairs of dizygotic twin and sibling pairs (DZ/Sib) were included. Results: EFT was positively associated with BMC in total, as well as in three subgroups (β = 0.107, 0.076, and 0.058 for men, pre-, and post-menopausal women, respectively). The positive association between EFT and BMC remained for DZ/Sib difference analysis, but was absent for MZ comparisons. The positive association between BMI and BMC was consistent for DZ/Sib and MZ difference analysis. After adjusting for the effect of general obesity via BMI, the association between BMC and EFT was statistically non-significant (β = 0.020, 0.000, and −0.009 for men, pre-, and post-menopausal women, respectively). Conclusion: Our findings do not support epicardial fat’s beneficial effects on bone health, whereas general adiposity has an osteotropic effect. The association between EFT and BMC is through common genetic component factors.https://www.jstage.jst.go.jp/article/jea/28/5/28_JE20170027/_pdfepicardial fatvisceral fatbone mineral content |
| spellingShingle | Dong-won Lee Min Soo Cho Eun Yeong Choe Seung Woo Park Yun-Mi Song Sang-Chol Lee Joohon Sung Epicardial Fat Thickness and Bone Mineral Content: The Healthy Twin Study in Korea Journal of Epidemiology epicardial fat visceral fat bone mineral content |
| title | Epicardial Fat Thickness and Bone Mineral Content: The Healthy Twin Study in Korea |
| title_full | Epicardial Fat Thickness and Bone Mineral Content: The Healthy Twin Study in Korea |
| title_fullStr | Epicardial Fat Thickness and Bone Mineral Content: The Healthy Twin Study in Korea |
| title_full_unstemmed | Epicardial Fat Thickness and Bone Mineral Content: The Healthy Twin Study in Korea |
| title_short | Epicardial Fat Thickness and Bone Mineral Content: The Healthy Twin Study in Korea |
| title_sort | epicardial fat thickness and bone mineral content the healthy twin study in korea |
| topic | epicardial fat visceral fat bone mineral content |
| url | https://www.jstage.jst.go.jp/article/jea/28/5/28_JE20170027/_pdf |
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