STRENGTH OF ANTI-DIPHTHERIA AND ANTI-TETANUS IMMUNITY IN HIV-INFECTED ADULTS
Effective antiretroviral therapy has transformed HIV into a manageable disease, therefore the issue of immunological prophylaxis of infectious diseases among these patients arises. Diphtheria and tetanus can only be prevented by vaccination. The purpose of the study was to assess the status of post-...
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| Format: | Article |
| Language: | English |
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Ukrainian Medical Stomatological Academy
2020-12-01
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| Series: | Вісник проблем біології і медицини |
| Subjects: | |
| Online Access: | https://vpbm.com.ua/upload/2020-4(158)/38-min.pdf |
| _version_ | 1818295308516327424 |
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| author | Revenko H. O. |
| author_facet | Revenko H. O. |
| author_sort | Revenko H. O. |
| collection | DOAJ |
| description | Effective antiretroviral therapy has transformed HIV into a manageable disease, therefore the issue of immunological prophylaxis of infectious diseases among these patients arises. Diphtheria and tetanus can only be prevented by vaccination. The purpose of the study was to assess the status of post-vaccination immunity against diphtheria and tetanus by investigating the seroprevalence of antibodies against these infections in HIV-infected adults. The total of 90 HIV-infected patients aged 22 to 60 years were examined (main group). The control group consisted of 49 immunocompetent volunteers of the corresponding age. Determination of the anti-diphtheria and anti-tetanus antibodies levels was carried out by means of immunoassay analysis using RIDASCREEN Diphtheria IgG and RIDASCREEN Tetanus IgG (R-Biopharm AG, Germany) diagnostic test systems. Statistical processing was performed using the STATISTICA v.6.1 licensed software. Significant differences were found between the titers of anti-toxic antibodies in HIV-infected and immunocompetent adults. The median of antidiphtherial antibodies in HIV-positive individuals was 0.17 (0.09-0.38) IU/ml, which is by 6.1 times lower than that in the control group – 1.03 (0.56-1.27) IU/ml (p<0.001 by the Mann-Whitney criterion). The median of anti-tetanus antibodies in the main group was 0.59 (0.28-1.09) IU/ml, which is by 2.3 times less than that in the control group – 1.33 (1.13-1.45) IU/ml (p<0.001). The population unprotected against diphtheria among the main group was 93.3% (n=84), against tetanus – 52.2% (n=47). There was no reliable association between the levels of antitoxic antibodies against diphtheria and tetanus and the number of CD4+ T-lymphocytes in HIV-infected individuals. HIV-positive adults constitute a risk group for potential diphtheria and tetanus as they have low specific immunity. It justifies their mandatory vaccination against these infectious diseases. |
| first_indexed | 2024-12-13T03:45:35Z |
| format | Article |
| id | doaj.art-b3a5378e3cd8458eaaca9def25ca30c1 |
| institution | Directory Open Access Journal |
| issn | 2077-4214 2523-4110 |
| language | English |
| last_indexed | 2024-12-13T03:45:35Z |
| publishDate | 2020-12-01 |
| publisher | Ukrainian Medical Stomatological Academy |
| record_format | Article |
| series | Вісник проблем біології і медицини |
| spelling | doaj.art-b3a5378e3cd8458eaaca9def25ca30c12022-12-22T00:00:50ZengUkrainian Medical Stomatological AcademyВісник проблем біології і медицини2077-42142523-41102020-12-01417818210.29254/2077-4214-2020-4-158-178-1822077-4214-2020-4-158-178-182STRENGTH OF ANTI-DIPHTHERIA AND ANTI-TETANUS IMMUNITY IN HIV-INFECTED ADULTSRevenko H. O.0 Dnipropetrovsk State Medical Academy, MOH of Ukraine Effective antiretroviral therapy has transformed HIV into a manageable disease, therefore the issue of immunological prophylaxis of infectious diseases among these patients arises. Diphtheria and tetanus can only be prevented by vaccination. The purpose of the study was to assess the status of post-vaccination immunity against diphtheria and tetanus by investigating the seroprevalence of antibodies against these infections in HIV-infected adults. The total of 90 HIV-infected patients aged 22 to 60 years were examined (main group). The control group consisted of 49 immunocompetent volunteers of the corresponding age. Determination of the anti-diphtheria and anti-tetanus antibodies levels was carried out by means of immunoassay analysis using RIDASCREEN Diphtheria IgG and RIDASCREEN Tetanus IgG (R-Biopharm AG, Germany) diagnostic test systems. Statistical processing was performed using the STATISTICA v.6.1 licensed software. Significant differences were found between the titers of anti-toxic antibodies in HIV-infected and immunocompetent adults. The median of antidiphtherial antibodies in HIV-positive individuals was 0.17 (0.09-0.38) IU/ml, which is by 6.1 times lower than that in the control group – 1.03 (0.56-1.27) IU/ml (p<0.001 by the Mann-Whitney criterion). The median of anti-tetanus antibodies in the main group was 0.59 (0.28-1.09) IU/ml, which is by 2.3 times less than that in the control group – 1.33 (1.13-1.45) IU/ml (p<0.001). The population unprotected against diphtheria among the main group was 93.3% (n=84), against tetanus – 52.2% (n=47). There was no reliable association between the levels of antitoxic antibodies against diphtheria and tetanus and the number of CD4+ T-lymphocytes in HIV-infected individuals. HIV-positive adults constitute a risk group for potential diphtheria and tetanus as they have low specific immunity. It justifies their mandatory vaccination against these infectious diseases. https://vpbm.com.ua/upload/2020-4(158)/38-min.pdf hiv infectionvaccinationimmunityseroprevalencediphtheriatetanus. |
| spellingShingle | Revenko H. O. STRENGTH OF ANTI-DIPHTHERIA AND ANTI-TETANUS IMMUNITY IN HIV-INFECTED ADULTS Вісник проблем біології і медицини hiv infection vaccination immunity seroprevalence diphtheria tetanus. |
| title | STRENGTH OF ANTI-DIPHTHERIA AND ANTI-TETANUS IMMUNITY IN HIV-INFECTED ADULTS |
| title_full | STRENGTH OF ANTI-DIPHTHERIA AND ANTI-TETANUS IMMUNITY IN HIV-INFECTED ADULTS |
| title_fullStr | STRENGTH OF ANTI-DIPHTHERIA AND ANTI-TETANUS IMMUNITY IN HIV-INFECTED ADULTS |
| title_full_unstemmed | STRENGTH OF ANTI-DIPHTHERIA AND ANTI-TETANUS IMMUNITY IN HIV-INFECTED ADULTS |
| title_short | STRENGTH OF ANTI-DIPHTHERIA AND ANTI-TETANUS IMMUNITY IN HIV-INFECTED ADULTS |
| title_sort | strength of anti diphtheria and anti tetanus immunity in hiv infected adults |
| topic | hiv infection vaccination immunity seroprevalence diphtheria tetanus. |
| url | https://vpbm.com.ua/upload/2020-4(158)/38-min.pdf |
| work_keys_str_mv | AT revenkoho strengthofantidiphtheriaandantitetanusimmunityinhivinfectedadults |