Research progress on the E protein of porcine reproductive and respiratory syndrome virus
Porcine reproductive and respiratory syndrome (PRRS) is an economically important disease impacting the global pig industry, and it is characterized by reproductive disorder in sows and respiratory disorder in pigs of all ages. The PRRSV E protein is a nonglycosylated structural protein encoded by t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1139628/full |
| _version_ | 1797826642125520896 |
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| author | Xiuqiao Chen JingHua Pan Liangzong Huang Liangzong Huang Mengmeng Zhao Mengmeng Zhao |
| author_facet | Xiuqiao Chen JingHua Pan Liangzong Huang Liangzong Huang Mengmeng Zhao Mengmeng Zhao |
| author_sort | Xiuqiao Chen |
| collection | DOAJ |
| description | Porcine reproductive and respiratory syndrome (PRRS) is an economically important disease impacting the global pig industry, and it is characterized by reproductive disorder in sows and respiratory disorder in pigs of all ages. The PRRSV E protein is a nonglycosylated structural protein encoded by the ORF2b gene. The E protein is not necessary for the assembly of virus particles, but deletion of the E protein leads to transmissible virus particles not being produced. To better understand the structure and function of the E protein, we reviewed its genetic and evolutionary analysis, characteristics, subcellular localization and topology, ion channel activity, cellular immune response, additional biological functions, interactions with host proteins, interactions with PRRSV proteins, roles in infection, pathogenicity, and drugs. Therefore, this review can provide a theoretical basis for gaining an in-depth understanding of the E protein of PRRSV-2. |
| first_indexed | 2024-04-09T12:35:40Z |
| format | Article |
| id | doaj.art-b3a8979d9e7d4ba7a53d2267a8170215 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-09T12:35:40Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-b3a8979d9e7d4ba7a53d2267a81702152023-05-15T13:19:34ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-05-011410.3389/fmicb.2023.11396281139628Research progress on the E protein of porcine reproductive and respiratory syndrome virusXiuqiao Chen0JingHua Pan1Liangzong Huang2Liangzong Huang3Mengmeng Zhao4Mengmeng Zhao5School of Life Science and Engineering, Foshan University, Foshan, ChinaSchool of Life Science and Engineering, Foshan University, Foshan, ChinaSchool of Life Science and Engineering, Foshan University, Foshan, ChinaVeterinary Teaching Hospital, Foshan University, Foshan, ChinaSchool of Life Science and Engineering, Foshan University, Foshan, ChinaVeterinary Teaching Hospital, Foshan University, Foshan, ChinaPorcine reproductive and respiratory syndrome (PRRS) is an economically important disease impacting the global pig industry, and it is characterized by reproductive disorder in sows and respiratory disorder in pigs of all ages. The PRRSV E protein is a nonglycosylated structural protein encoded by the ORF2b gene. The E protein is not necessary for the assembly of virus particles, but deletion of the E protein leads to transmissible virus particles not being produced. To better understand the structure and function of the E protein, we reviewed its genetic and evolutionary analysis, characteristics, subcellular localization and topology, ion channel activity, cellular immune response, additional biological functions, interactions with host proteins, interactions with PRRSV proteins, roles in infection, pathogenicity, and drugs. Therefore, this review can provide a theoretical basis for gaining an in-depth understanding of the E protein of PRRSV-2.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1139628/fullPRRSVE proteinORF2bion channeltransmissible |
| spellingShingle | Xiuqiao Chen JingHua Pan Liangzong Huang Liangzong Huang Mengmeng Zhao Mengmeng Zhao Research progress on the E protein of porcine reproductive and respiratory syndrome virus Frontiers in Microbiology PRRSV E protein ORF2b ion channel transmissible |
| title | Research progress on the E protein of porcine reproductive and respiratory syndrome virus |
| title_full | Research progress on the E protein of porcine reproductive and respiratory syndrome virus |
| title_fullStr | Research progress on the E protein of porcine reproductive and respiratory syndrome virus |
| title_full_unstemmed | Research progress on the E protein of porcine reproductive and respiratory syndrome virus |
| title_short | Research progress on the E protein of porcine reproductive and respiratory syndrome virus |
| title_sort | research progress on the e protein of porcine reproductive and respiratory syndrome virus |
| topic | PRRSV E protein ORF2b ion channel transmissible |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1139628/full |
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