Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development

Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development

Background Endocardial cells are a major progenitor population that gives rise to heart valves through endocardial cushion formation by endocardial to mesenchymal transformation and the subsequent endocardial cushion remodeling. Genetic variants that affect these developmental processes can lead to...

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Bibliographic Details
Main Authors: Bingruo Wu, Brian Wu, Sonia Benkaci, Lijie Shi, Pengfei Lu, Taeju Park, Bernice E. Morrow, Yidong Wang, Bin Zhou
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
Crk
Crkl
endocardial cushion
endocardium
heart valve development
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.123.029683

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