Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway

Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway

Abstract Background After surgery, wound recovery in diabetic patients may be disrupted due to delayed inflammation, which can lead to undesired consequences, and there is currently a lack of effective measures to address this issue. Mesenchymal stem cell (MSC)-derived exosomes (Exo) have been prove...

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Bibliographic Details
Main Authors: Wei Liu, Muyu Yu, Dong Xie, Longqing Wang, Cheng Ye, Qi Zhu, Fang Liu, Lili Yang
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Stem Cell Research & Therapy
Subjects:
Exosome
Mesenchymal stem cell
Melatonin
Macrophage polarization
Diabetic wound
Inflammation
Online Access:http://link.springer.com/article/10.1186/s13287-020-01756-x

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