Novel Liver X Receptor Ligand GAC0001E5 Disrupts Glutamine Metabolism and Induces Oxidative Stress in Pancreatic Cancer Cells
Pancreatic ductal adenocarcinoma (PDAC) is the predominant form of pancreatic cancer with a high mortality rate due to the lack of early detection and effective treatment options for advanced diseases. Metabolic reprogramming, a common hallmark of malignant transformation in pancreatic cancer, is cr...
Main Authors: | Shivangi Srivastava, Scott Widmann, Charles Ho, Donovan Nguyen, Alexis Nguyen, Asitha Premaratne, Jan-Åke Gustafsson, Chin-Yo Lin |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-12-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/24/9622 |
Similar Items
-
Liver X Receptor Inverse Agonist GAC0001E5 Impedes Glutaminolysis and Disrupts Redox Homeostasis in Breast Cancer Cells
by: Asitha Premaratne, et al.
Published: (2023-02-01) -
Exploiting the Achilles’ heel of cancer: disrupting glutamine metabolism for effective cancer treatment
by: Yuxin Fan, et al.
Published: (2024-03-01) -
Glutamine deprivation induces ferroptosis in pancreatic cancer cells
by: Xiao Zhiwen, et al.
Published: (2023-03-01) -
Leukemia Cells Resistant to Glutamine Deprivation Express Glutamine Synthetase Protein
by: Burcu Yücel, et al.
Published: (2022-02-01) -
Glutamine synthetase expression rescues human dendritic cell survival in a glutamine-deprived environment
by: Robert Schoeppe, et al.
Published: (2023-01-01)