Inflammation in Urological Malignancies: The Silent Killer
Several studies have investigated the role of inflammation in promoting tumorigenesis and cancer progression. Neoplastic as well as surrounding stromal and inflammatory cells engage in well-orchestrated reciprocal interactions to establish an inflammatory tumor microenvironment. The tumor-associated...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/1/866 |
| _version_ | 1797625564317614080 |
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| author | Martina Catalano Giandomenico Roviello Raffaella Santi Donata Villari Pietro Spatafora Ilaria Camilla Galli Francesco Sessa Francesco Lupo Conte Enrico Mini Tommaso Cai Gabriella Nesi |
| author_facet | Martina Catalano Giandomenico Roviello Raffaella Santi Donata Villari Pietro Spatafora Ilaria Camilla Galli Francesco Sessa Francesco Lupo Conte Enrico Mini Tommaso Cai Gabriella Nesi |
| author_sort | Martina Catalano |
| collection | DOAJ |
| description | Several studies have investigated the role of inflammation in promoting tumorigenesis and cancer progression. Neoplastic as well as surrounding stromal and inflammatory cells engage in well-orchestrated reciprocal interactions to establish an inflammatory tumor microenvironment. The tumor-associated inflammatory tissue is highly plastic, capable of continuously modifying its phenotypic and functional characteristics. Accumulating evidence suggests that chronic inflammation plays a critical role in the development of urological cancers. Here, we review the origins of inflammation in urothelial, prostatic, renal, testicular, and penile cancers, focusing on the mechanisms that drive tumor initiation, growth, progression, and metastasis. We also discuss how tumor-associated inflammatory tissue may be a diagnostic marker of clinically significant tumor progression risk and the target for future anti-cancer therapies. |
| first_indexed | 2024-03-11T09:58:09Z |
| format | Article |
| id | doaj.art-b3ab5b00cee5438689875d3d6674dbfa |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:58:09Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b3ab5b00cee5438689875d3d6674dbfa2023-11-16T15:39:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-0124186610.3390/ijms24010866Inflammation in Urological Malignancies: The Silent KillerMartina Catalano0Giandomenico Roviello1Raffaella Santi2Donata Villari3Pietro Spatafora4Ilaria Camilla Galli5Francesco Sessa6Francesco Lupo Conte7Enrico Mini8Tommaso Cai9Gabriella Nesi10School of Human Health Sciences, University of Florence, 50134 Florence, ItalySection of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, 50139 Florence, ItalySection of Pathological Anatomy, Department of Health Sciences, University of Florence, 50139 Florence, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, ItalyUnit of Urological Robotic Surgery and Renal Transplantation, Careggi Teaching Hospital, 50134 Florence, ItalyHistopathology and Molecular Diagnostics, Careggi Teaching Hospital, 50139 Florence, ItalyUnit of Urological Robotic Surgery and Renal Transplantation, Careggi Teaching Hospital, 50134 Florence, ItalySchool of Human Health Sciences, University of Florence, 50134 Florence, ItalySection of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, 50139 Florence, ItalyDepartment of Urology, Santa Chiara Regional Hospital, 38122 Trento, ItalySection of Pathological Anatomy, Department of Health Sciences, University of Florence, 50139 Florence, ItalySeveral studies have investigated the role of inflammation in promoting tumorigenesis and cancer progression. Neoplastic as well as surrounding stromal and inflammatory cells engage in well-orchestrated reciprocal interactions to establish an inflammatory tumor microenvironment. The tumor-associated inflammatory tissue is highly plastic, capable of continuously modifying its phenotypic and functional characteristics. Accumulating evidence suggests that chronic inflammation plays a critical role in the development of urological cancers. Here, we review the origins of inflammation in urothelial, prostatic, renal, testicular, and penile cancers, focusing on the mechanisms that drive tumor initiation, growth, progression, and metastasis. We also discuss how tumor-associated inflammatory tissue may be a diagnostic marker of clinically significant tumor progression risk and the target for future anti-cancer therapies.https://www.mdpi.com/1422-0067/24/1/866inflammationtumorigenesiscancergenitourinary tumors |
| spellingShingle | Martina Catalano Giandomenico Roviello Raffaella Santi Donata Villari Pietro Spatafora Ilaria Camilla Galli Francesco Sessa Francesco Lupo Conte Enrico Mini Tommaso Cai Gabriella Nesi Inflammation in Urological Malignancies: The Silent Killer International Journal of Molecular Sciences inflammation tumorigenesis cancer genitourinary tumors |
| title | Inflammation in Urological Malignancies: The Silent Killer |
| title_full | Inflammation in Urological Malignancies: The Silent Killer |
| title_fullStr | Inflammation in Urological Malignancies: The Silent Killer |
| title_full_unstemmed | Inflammation in Urological Malignancies: The Silent Killer |
| title_short | Inflammation in Urological Malignancies: The Silent Killer |
| title_sort | inflammation in urological malignancies the silent killer |
| topic | inflammation tumorigenesis cancer genitourinary tumors |
| url | https://www.mdpi.com/1422-0067/24/1/866 |
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