Extracellular Nucleotides Regulate Arterial Calcification by Activating Both Independent and Dependent Purinergic Receptor Signaling Pathways

Extracellular Nucleotides Regulate Arterial Calcification by Activating Both Independent and Dependent Purinergic Receptor Signaling Pathways

Arterial calcification, the deposition of calcium-phosphate crystals in the extracellular matrix, resembles physiological bone mineralization. It is well-known that extracellular nucleotides regulate bone homeostasis raising an emerging interest in the role of these molecules on arterial calcificati...

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Bibliographic Details
Main Authors: Britt Opdebeeck, Isabel R. Orriss, Ellen Neven, Patrick C. D’Haese, Anja Verhulst
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
arterial calcification
purinergic signaling
pyrophosphate
ecto-nucleotidases
extracellular nucleotides
Online Access:https://www.mdpi.com/1422-0067/21/20/7636

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