Thrombospondin type-1 domain-containing 7A-associated membranous nephropathy after resection of rectal cancer: a case report
Abstract Background Thrombospondin type-1 domain-containing 7A (THSD7A) is a target antigen in idiopathic membranous nephropathy (MN). Patients with THSD7A-associated MN are known to have a high possibility of developing malignancy. However, there are few case reports on THSD7A-associated MN with ma...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | BMC Nephrology |
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| Online Access: | http://link.springer.com/article/10.1186/s12882-019-1236-y |
| _version_ | 1819091412360101888 |
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| author | Shinya Taguchi Yoshiki Koshikawa Shoya Ohyama Hiroko Miyachi Hiroaki Ozawa Hiroaki Asada |
| author_facet | Shinya Taguchi Yoshiki Koshikawa Shoya Ohyama Hiroko Miyachi Hiroaki Ozawa Hiroaki Asada |
| author_sort | Shinya Taguchi |
| collection | DOAJ |
| description | Abstract Background Thrombospondin type-1 domain-containing 7A (THSD7A) is a target antigen in idiopathic membranous nephropathy (MN). Patients with THSD7A-associated MN are known to have a high possibility of developing malignancy. However, there are few case reports on THSD7A-associated MN with malignancy, and details of its characteristics have not been clarified thoroughly. Here, we report the case of a 77-year-old male patient who was diagnosed with THSD7A-associated MN after resection of rectal cancer. Case presentation A 77-year-old man who had developed bilateral peripheral edema, persistent proteinuria, and nephrotic syndrome was admitted to our hospital. He was diagnosed with MN based on a renal biopsy 3 years after resection of rectal cancer, and positive staining for THSD7A in both kidney and rectal cancer tissues suggested that these two diseases were related. Furthermore, THSD7A staining of metastatic lymph nodes revealed deposition of THSD7A in the secondary lymph follicles and sinus. Recurrence of rectal cancer was suspected; however, tumor recurrence was not observed on chest and abdominal computed tomography (CT) and colonoscopy. There was no lymph node enlargement. The patient was kept on observation with supportive therapy. Consequently, although nephrotic syndrome persisted, obvious recurrence and metastasis of the primary tumor were not observed. Conclusion This is the first case in which pathological examination results suggested that THSD7A-associated MN was caused by rectal cancer. Based on the reports of THSD7A-associated MN with malignancy and the pathogenesis of MN, lymph node metastasis may be a risk for cancer-related MN. |
| first_indexed | 2024-12-21T22:39:19Z |
| format | Article |
| id | doaj.art-b3ac4d4f7e684895b00de5f3ef9ee6c6 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-21T22:39:19Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-b3ac4d4f7e684895b00de5f3ef9ee6c62022-12-21T18:47:53ZengBMCBMC Nephrology1471-23692019-02-012011610.1186/s12882-019-1236-yThrombospondin type-1 domain-containing 7A-associated membranous nephropathy after resection of rectal cancer: a case reportShinya Taguchi0Yoshiki Koshikawa1Shoya Ohyama2Hiroko Miyachi3Hiroaki Ozawa4Hiroaki Asada5Department of Nephrology, Okazaki City HospitalDepartment of Nephrology, Okazaki City HospitalDepartment of Nephrology, Okazaki City HospitalDepartment of Nephrology, Okazaki City HospitalDepartment of Pathology, Okazaki City hospitalDepartment of Nephrology, Okazaki City HospitalAbstract Background Thrombospondin type-1 domain-containing 7A (THSD7A) is a target antigen in idiopathic membranous nephropathy (MN). Patients with THSD7A-associated MN are known to have a high possibility of developing malignancy. However, there are few case reports on THSD7A-associated MN with malignancy, and details of its characteristics have not been clarified thoroughly. Here, we report the case of a 77-year-old male patient who was diagnosed with THSD7A-associated MN after resection of rectal cancer. Case presentation A 77-year-old man who had developed bilateral peripheral edema, persistent proteinuria, and nephrotic syndrome was admitted to our hospital. He was diagnosed with MN based on a renal biopsy 3 years after resection of rectal cancer, and positive staining for THSD7A in both kidney and rectal cancer tissues suggested that these two diseases were related. Furthermore, THSD7A staining of metastatic lymph nodes revealed deposition of THSD7A in the secondary lymph follicles and sinus. Recurrence of rectal cancer was suspected; however, tumor recurrence was not observed on chest and abdominal computed tomography (CT) and colonoscopy. There was no lymph node enlargement. The patient was kept on observation with supportive therapy. Consequently, although nephrotic syndrome persisted, obvious recurrence and metastasis of the primary tumor were not observed. Conclusion This is the first case in which pathological examination results suggested that THSD7A-associated MN was caused by rectal cancer. Based on the reports of THSD7A-associated MN with malignancy and the pathogenesis of MN, lymph node metastasis may be a risk for cancer-related MN.http://link.springer.com/article/10.1186/s12882-019-1236-yThrombospondin type-1 domain-containing 7AMembranous nephropathyMalignancyRectal cancerPhospholipase A2 receptor |
| spellingShingle | Shinya Taguchi Yoshiki Koshikawa Shoya Ohyama Hiroko Miyachi Hiroaki Ozawa Hiroaki Asada Thrombospondin type-1 domain-containing 7A-associated membranous nephropathy after resection of rectal cancer: a case report BMC Nephrology Thrombospondin type-1 domain-containing 7A Membranous nephropathy Malignancy Rectal cancer Phospholipase A2 receptor |
| title | Thrombospondin type-1 domain-containing 7A-associated membranous nephropathy after resection of rectal cancer: a case report |
| title_full | Thrombospondin type-1 domain-containing 7A-associated membranous nephropathy after resection of rectal cancer: a case report |
| title_fullStr | Thrombospondin type-1 domain-containing 7A-associated membranous nephropathy after resection of rectal cancer: a case report |
| title_full_unstemmed | Thrombospondin type-1 domain-containing 7A-associated membranous nephropathy after resection of rectal cancer: a case report |
| title_short | Thrombospondin type-1 domain-containing 7A-associated membranous nephropathy after resection of rectal cancer: a case report |
| title_sort | thrombospondin type 1 domain containing 7a associated membranous nephropathy after resection of rectal cancer a case report |
| topic | Thrombospondin type-1 domain-containing 7A Membranous nephropathy Malignancy Rectal cancer Phospholipase A2 receptor |
| url | http://link.springer.com/article/10.1186/s12882-019-1236-y |
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