The role of mitochondrial dynamics in cerebral ischemia-reperfusion injury
Stroke is one of the leading causes of death and long-term disability worldwide. More than 80 % of strokes are ischemic, caused by an occlusion of cerebral arteries. Without question, restoration of blood supply as soon as possible is the first therapeutic strategy. Nonetheless paradoxically, reperf...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223004596 |
| _version_ | 1797837186346778624 |
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| author | Jie Huang Lei Chen Zi-meng Yao Xiao-rong Sun Xu-hui Tong Shu-ying Dong |
| author_facet | Jie Huang Lei Chen Zi-meng Yao Xiao-rong Sun Xu-hui Tong Shu-ying Dong |
| author_sort | Jie Huang |
| collection | DOAJ |
| description | Stroke is one of the leading causes of death and long-term disability worldwide. More than 80 % of strokes are ischemic, caused by an occlusion of cerebral arteries. Without question, restoration of blood supply as soon as possible is the first therapeutic strategy. Nonetheless paradoxically, reperfusion can further aggravate the injury through a series of reactions known as cerebral ischemia-reperfusion injury (CIRI). Mitochondria play a vital role in promoting nerve survival and neurological function recovery and mitochondrial dysfunction is considered one of the characteristics of CIRI. Neurons often die due to oxidative stress and an imbalance in energy metabolism following CIRI, and there is a strong association with mitochondrial dysfunction. Altered mitochondrial dynamics is the first reaction of mitochondrial stress. Mitochondrial dynamics refers to the maintenance of the integrity, distribution, and size of mitochondria as well as their ability to resist external stimuli through a continuous cycle of mitochondrial fission and fusion. Therefore, improving mitochondrial dynamics is a vital means of treating CIRI. This review discusses the relationship between mitochondria and CIRI and emphasizes improving mitochondrial dynamics as a potential therapeutic approach to improve the prognosis of CIRI. |
| first_indexed | 2024-04-09T15:20:46Z |
| format | Article |
| id | doaj.art-b3acca89cf394a6da31d00e067f5ce6c |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-09T15:20:46Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-b3acca89cf394a6da31d00e067f5ce6c2023-04-29T14:46:16ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-06-01162114671The role of mitochondrial dynamics in cerebral ischemia-reperfusion injuryJie Huang0Lei Chen1Zi-meng Yao2Xiao-rong Sun3Xu-hui Tong4Shu-ying Dong5Department of Pharmacology, School of Pharmacy, Bengbu Medical College, Bengbu, China; Anhui Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu, ChinaDepartment of Pharmacology, School of Pharmacy, Bengbu Medical College, Bengbu, China; Anhui Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu, ChinaDepartment of Pharmacology, School of Pharmacy, Bengbu Medical College, Bengbu, China; Anhui Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu, ChinaDepartment of Pharmacology, School of Pharmacy, Bengbu Medical College, Bengbu, China; Anhui Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu, ChinaDepartment of Pharmacology, School of Pharmacy, Bengbu Medical College, Bengbu, China; Anhui Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu, ChinaDepartment of Pharmacology, School of Pharmacy, Bengbu Medical College, Bengbu, China; Anhui Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu, China; Bengbu Medical College Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Bengbu, China; Correspondence to: School of Pharmacy, Bengbu Medical College, Bengbu, China.Stroke is one of the leading causes of death and long-term disability worldwide. More than 80 % of strokes are ischemic, caused by an occlusion of cerebral arteries. Without question, restoration of blood supply as soon as possible is the first therapeutic strategy. Nonetheless paradoxically, reperfusion can further aggravate the injury through a series of reactions known as cerebral ischemia-reperfusion injury (CIRI). Mitochondria play a vital role in promoting nerve survival and neurological function recovery and mitochondrial dysfunction is considered one of the characteristics of CIRI. Neurons often die due to oxidative stress and an imbalance in energy metabolism following CIRI, and there is a strong association with mitochondrial dysfunction. Altered mitochondrial dynamics is the first reaction of mitochondrial stress. Mitochondrial dynamics refers to the maintenance of the integrity, distribution, and size of mitochondria as well as their ability to resist external stimuli through a continuous cycle of mitochondrial fission and fusion. Therefore, improving mitochondrial dynamics is a vital means of treating CIRI. This review discusses the relationship between mitochondria and CIRI and emphasizes improving mitochondrial dynamics as a potential therapeutic approach to improve the prognosis of CIRI.http://www.sciencedirect.com/science/article/pii/S0753332223004596Cerebral ischemia-reperfusion injuryMitochondriaMitochondrial dynamics |
| spellingShingle | Jie Huang Lei Chen Zi-meng Yao Xiao-rong Sun Xu-hui Tong Shu-ying Dong The role of mitochondrial dynamics in cerebral ischemia-reperfusion injury Biomedicine & Pharmacotherapy Cerebral ischemia-reperfusion injury Mitochondria Mitochondrial dynamics |
| title | The role of mitochondrial dynamics in cerebral ischemia-reperfusion injury |
| title_full | The role of mitochondrial dynamics in cerebral ischemia-reperfusion injury |
| title_fullStr | The role of mitochondrial dynamics in cerebral ischemia-reperfusion injury |
| title_full_unstemmed | The role of mitochondrial dynamics in cerebral ischemia-reperfusion injury |
| title_short | The role of mitochondrial dynamics in cerebral ischemia-reperfusion injury |
| title_sort | role of mitochondrial dynamics in cerebral ischemia reperfusion injury |
| topic | Cerebral ischemia-reperfusion injury Mitochondria Mitochondrial dynamics |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223004596 |
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