Development of epoxyeicosatrienoic acid analogs with in vivo anti-hypertensive actions

Development of epoxyeicosatrienoic acid analogs with in vivo anti-hypertensive actions

Epoxyeicosatrienoic acids (EETs) contribute importantly to the regulation of vascular tone and blood pressure control. The purpose of this study was to develop stable EET analogs and test their in vivo blood pressure lowering effects in hypertensive rats. Using the pharmacophoric moiety of EETs, eth...

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Bibliographic Details
Main Authors: John D Imig, Ahmed eElmarakby, Kasem eNithipatikom, Shouzou eWei, Jorge H Capdevila, Venugopal R Tuniki, Bhavani eSangras, Siddam eAnjaiah, Vijaya L Manthati, D. Sudarashan Reddy, John R Falck
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-12-01
Series:Frontiers in Physiology
Subjects:
Blood Pressure
Hypertension
Vasodilation
afferent arteriole
epoxyeicosanoids
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2010.00157/full

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