Cannabinoids and neuroinflammation: Therapeutic implications
This review summarizes the pharmacological properties of tetrahydrocannabinol (THC) and cannabidiol (CBD), cannabinoid components of several species of herbal cannabis. The pharmacological effects of the phytocannabinoids have been extensively investigated and the importance of the cannabinoid recep...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Journal of Affective Disorders Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666915323000021 |
| _version_ | 1827965423460548608 |
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| author | Brian E. Leonard Feyza Aricioglu |
| author_facet | Brian E. Leonard Feyza Aricioglu |
| author_sort | Brian E. Leonard |
| collection | DOAJ |
| description | This review summarizes the pharmacological properties of tetrahydrocannabinol (THC) and cannabidiol (CBD), cannabinoid components of several species of herbal cannabis. The pharmacological effects of the phytocannabinoids have been extensively investigated and the importance of the cannabinoid receptors (CB1 and CB2) on immune cells has provided important information on the intracellular targets for these molecules. In addition to the phytocannabinoids, endogenous cannabinoids also exist in the form of anadramide and 2-srodolylglycerol (2-AG). These, together with their synthesizing and metabolizing enzymes, form the cannabinoid system. Since the discovery of the endocannabinoid system and the role that neuroinflammation plays in neurological and psychiatric illness, the potential therapeutic importance of this system has been of growing interest. In addition, the need to develop drugs which specifically target the CB1 and CB2 receptors has been stimulated by the pharmacological complexity of both THC and CBD. This review briefly summarizes the therapeutic potential of the naturally occurring and the synthetic cannabinoids which will need to be developed, if such drugs are to fulfill the therapeutic promise which the cannabinoids offer. |
| first_indexed | 2024-04-09T17:32:48Z |
| format | Article |
| id | doaj.art-b3ae701c809145218eceeef34ed6f730 |
| institution | Directory Open Access Journal |
| issn | 2666-9153 |
| language | English |
| last_indexed | 2024-04-09T17:32:48Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Affective Disorders Reports |
| spelling | doaj.art-b3ae701c809145218eceeef34ed6f7302023-04-18T04:09:15ZengElsevierJournal of Affective Disorders Reports2666-91532023-04-0112100463Cannabinoids and neuroinflammation: Therapeutic implicationsBrian E. Leonard0Feyza Aricioglu1Emeritus Professor of Pharmacology, National University of Ireland, Galway, Ireland; Corresponding author.Professor of Pharmacology, Marmara University, Institute of Health Sciences, Istanbul, TurkeyThis review summarizes the pharmacological properties of tetrahydrocannabinol (THC) and cannabidiol (CBD), cannabinoid components of several species of herbal cannabis. The pharmacological effects of the phytocannabinoids have been extensively investigated and the importance of the cannabinoid receptors (CB1 and CB2) on immune cells has provided important information on the intracellular targets for these molecules. In addition to the phytocannabinoids, endogenous cannabinoids also exist in the form of anadramide and 2-srodolylglycerol (2-AG). These, together with their synthesizing and metabolizing enzymes, form the cannabinoid system. Since the discovery of the endocannabinoid system and the role that neuroinflammation plays in neurological and psychiatric illness, the potential therapeutic importance of this system has been of growing interest. In addition, the need to develop drugs which specifically target the CB1 and CB2 receptors has been stimulated by the pharmacological complexity of both THC and CBD. This review briefly summarizes the therapeutic potential of the naturally occurring and the synthetic cannabinoids which will need to be developed, if such drugs are to fulfill the therapeutic promise which the cannabinoids offer.http://www.sciencedirect.com/science/article/pii/S2666915323000021PhytocannabinoidsTHC and CBDendogenous cannabinoidsanadamide and 2-AGMicrogliaNeuroinflammation |
| spellingShingle | Brian E. Leonard Feyza Aricioglu Cannabinoids and neuroinflammation: Therapeutic implications Journal of Affective Disorders Reports Phytocannabinoids THC and CBD endogenous cannabinoids anadamide and 2-AG Microglia Neuroinflammation |
| title | Cannabinoids and neuroinflammation: Therapeutic implications |
| title_full | Cannabinoids and neuroinflammation: Therapeutic implications |
| title_fullStr | Cannabinoids and neuroinflammation: Therapeutic implications |
| title_full_unstemmed | Cannabinoids and neuroinflammation: Therapeutic implications |
| title_short | Cannabinoids and neuroinflammation: Therapeutic implications |
| title_sort | cannabinoids and neuroinflammation therapeutic implications |
| topic | Phytocannabinoids THC and CBD endogenous cannabinoids anadamide and 2-AG Microglia Neuroinflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2666915323000021 |
| work_keys_str_mv | AT brianeleonard cannabinoidsandneuroinflammationtherapeuticimplications AT feyzaaricioglu cannabinoidsandneuroinflammationtherapeuticimplications |