Fanconi Anemia repair pathway dysfunction, a potential therapeutic target in lung cancer

Fanconi Anemia repair pathway dysfunction, a potential therapeutic target in lung cancer

The Fanconi Anemia (FA) pathway is a major mechanism of homologous recombination DNA repair. The functional readout of the pathway is activation through mono-ubiquitination of FANCD2 leading to nuclear foci of repair. We have recently developed an FA triple staining immunofluorescence based method...

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Bibliographic Details
Main Authors: Wenrui eDuan, Li eGao, Brittany eAguila, Arjun eKalvala, Gregory A Otterson, Miguel Angel Villalona
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Oncology
Subjects:
Fanconi Anemia
lung cancer
Therapeutic target
Pathway dysfunction
FATSI
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00368/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00368/full

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