Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer
Liquid biopsies could be valuable tools to monitor breast cancer progression and evolution. Here, the authors investigate genomic profiling of tissue and liquid biopsies in a large cohort of patients with breast cancer during the course of therapy to characterise tumour evolution and acquired mutati...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35245-x |
| _version_ | 1811302028590186496 |
|---|---|
| author | Smruthy Sivakumar Dexter X. Jin Hanna Tukachinsky Karthikeyan Murugesan Kimberly McGregor Natalie Danziger Dean Pavlick Ole Gjoerup Jeffrey S. Ross Robert Harmon Jon Chung Brennan Decker Lucas Dennis Garrett M. Frampton Luciana Molinero Steffi Oesterreich Jeffrey M. Venstrom Geoffrey R. Oxnard Priti S. Hegde Ethan S. Sokol |
| author_facet | Smruthy Sivakumar Dexter X. Jin Hanna Tukachinsky Karthikeyan Murugesan Kimberly McGregor Natalie Danziger Dean Pavlick Ole Gjoerup Jeffrey S. Ross Robert Harmon Jon Chung Brennan Decker Lucas Dennis Garrett M. Frampton Luciana Molinero Steffi Oesterreich Jeffrey M. Venstrom Geoffrey R. Oxnard Priti S. Hegde Ethan S. Sokol |
| author_sort | Smruthy Sivakumar |
| collection | DOAJ |
| description | Liquid biopsies could be valuable tools to monitor breast cancer progression and evolution. Here, the authors investigate genomic profiling of tissue and liquid biopsies in a large cohort of patients with breast cancer during the course of therapy to characterise tumour evolution and acquired mutations. |
| first_indexed | 2024-04-13T07:19:19Z |
| format | Article |
| id | doaj.art-b3aeff304c474e6c83d5647b3e086870 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T07:19:19Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b3aeff304c474e6c83d5647b3e0868702022-12-22T02:56:39ZengNature PortfolioNature Communications2041-17232022-12-0113111310.1038/s41467-022-35245-xTissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancerSmruthy Sivakumar0Dexter X. Jin1Hanna Tukachinsky2Karthikeyan Murugesan3Kimberly McGregor4Natalie Danziger5Dean Pavlick6Ole Gjoerup7Jeffrey S. Ross8Robert Harmon9Jon Chung10Brennan Decker11Lucas Dennis12Garrett M. Frampton13Luciana Molinero14Steffi Oesterreich15Jeffrey M. Venstrom16Geoffrey R. Oxnard17Priti S. Hegde18Ethan S. Sokol19Foundation Medicine, Inc.Foundation Medicine, Inc.Foundation Medicine, Inc.Foundation Medicine, Inc.Foundation Medicine, Inc.Foundation Medicine, Inc.Foundation Medicine, Inc.Foundation Medicine, Inc.Foundation Medicine, Inc.Foundation Medicine, Inc.Foundation Medicine, Inc.Foundation Medicine, Inc.Foundation Medicine, Inc.Foundation Medicine, Inc.Genentech, Inc.Department of Pharmacology and Chemical Biology, University of PittsburghFoundation Medicine, Inc.Foundation Medicine, Inc.Foundation Medicine, Inc.Foundation Medicine, Inc.Liquid biopsies could be valuable tools to monitor breast cancer progression and evolution. Here, the authors investigate genomic profiling of tissue and liquid biopsies in a large cohort of patients with breast cancer during the course of therapy to characterise tumour evolution and acquired mutations.https://doi.org/10.1038/s41467-022-35245-x |
| spellingShingle | Smruthy Sivakumar Dexter X. Jin Hanna Tukachinsky Karthikeyan Murugesan Kimberly McGregor Natalie Danziger Dean Pavlick Ole Gjoerup Jeffrey S. Ross Robert Harmon Jon Chung Brennan Decker Lucas Dennis Garrett M. Frampton Luciana Molinero Steffi Oesterreich Jeffrey M. Venstrom Geoffrey R. Oxnard Priti S. Hegde Ethan S. Sokol Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer Nature Communications |
| title | Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer |
| title_full | Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer |
| title_fullStr | Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer |
| title_full_unstemmed | Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer |
| title_short | Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer |
| title_sort | tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer |
| url | https://doi.org/10.1038/s41467-022-35245-x |
| work_keys_str_mv | AT smruthysivakumar tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT dexterxjin tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT hannatukachinsky tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT karthikeyanmurugesan tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT kimberlymcgregor tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT nataliedanziger tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT deanpavlick tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT olegjoerup tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT jeffreysross tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT robertharmon tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT jonchung tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT brennandecker tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT lucasdennis tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT garrettmframpton tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT lucianamolinero tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT steffioesterreich tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT jeffreymvenstrom tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT geoffreyroxnard tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT pritishegde tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer AT ethanssokol tissueandliquidbiopsyprofilingrevealconvergenttumorevolutionandtherapyevasioninbreastcancer |