Vascular endothelial growth factor and hypoxia-inducible factor-1α gene polymorphisms and coronary collateral formation in patients with coronary chronic total occlusions
Introduction: We evaluated the association between two single nucleotide polymorphisms of the vascular endothelial growth factor gene and one of the hypoxia-inducible factor-1α gene and the degree of coronary collateral formation in patients with a coronary chronic total occlusion. Methods: Totally,...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2016-06-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/2050312116654403 |
| _version_ | 1819056263553613824 |
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| author | Vincent Amoah Benjamin Wrigley Eric Holroyd Andrew Smallwood Angel L Armesilla Alan Nevill James Cotton |
| author_facet | Vincent Amoah Benjamin Wrigley Eric Holroyd Andrew Smallwood Angel L Armesilla Alan Nevill James Cotton |
| author_sort | Vincent Amoah |
| collection | DOAJ |
| description | Introduction: We evaluated the association between two single nucleotide polymorphisms of the vascular endothelial growth factor gene and one of the hypoxia-inducible factor-1α gene and the degree of coronary collateral formation in patients with a coronary chronic total occlusion. Methods: Totally, 98 patients with symptomatic coronary artery disease and a chronic total occlusion observed during coronary angiography were recruited. Genotyping of two vascular endothelial growth factor promoter single nucleotide polymorphisms (−152G>A and −165C>T) and the C1772T single nucleotide polymorphism of hypoxia-inducible factor-1α were performed using polymerase chain reaction and restriction fragment length polymorphism analysis. The presence and extent of collateral vessel filling was scored by blinded observers using the Rentrop grade. Results: We found no association between the vascular endothelial growth factor −152G>A, −165C>T and hypoxia-inducible factor-1α −1772C>T with the presence and filling of coronary collateral vessels. A history of percutaneous coronary intervention and transient ischaemic attack/cerebrovascular accident were associated with the presence of enhanced collateral vessel formation following binary logistic regression analysis. Conclusion: The study findings suggest that coronary collateral formation is not associated with the tested polymorphic variants of vascular endothelial growth factor and hypoxia-inducible factor-1α in patients with symptomatic coronary artery disease and the presence of a chronic total occlusion. |
| first_indexed | 2024-12-21T13:20:38Z |
| format | Article |
| id | doaj.art-b3afbba6288447399ba94561d40534e0 |
| institution | Directory Open Access Journal |
| issn | 2050-3121 |
| language | English |
| last_indexed | 2024-12-21T13:20:38Z |
| publishDate | 2016-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj.art-b3afbba6288447399ba94561d40534e02022-12-21T19:02:35ZengSAGE PublishingSAGE Open Medicine2050-31212016-06-01410.1177/205031211665440310.1177_2050312116654403Vascular endothelial growth factor and hypoxia-inducible factor-1α gene polymorphisms and coronary collateral formation in patients with coronary chronic total occlusionsVincent Amoah0Benjamin Wrigley1Eric Holroyd2Andrew Smallwood3Angel L Armesilla4Alan Nevill5James Cotton6Department of Cardiology, Heart and Lung Centre, New Cross Hospital, Wolverhampton, UKDepartment of Cardiology, Heart and Lung Centre, New Cross Hospital, Wolverhampton, UKDepartment of Cardiology, Heart and Lung Centre, New Cross Hospital, Wolverhampton, UKDepartment of Cardiology, Heart and Lung Centre, New Cross Hospital, Wolverhampton, UKResearch Institute in Healthcare Science, School of Pharmacy, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UKFaculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, UKDepartment of Cardiology, Heart and Lung Centre, New Cross Hospital, Wolverhampton, UKIntroduction: We evaluated the association between two single nucleotide polymorphisms of the vascular endothelial growth factor gene and one of the hypoxia-inducible factor-1α gene and the degree of coronary collateral formation in patients with a coronary chronic total occlusion. Methods: Totally, 98 patients with symptomatic coronary artery disease and a chronic total occlusion observed during coronary angiography were recruited. Genotyping of two vascular endothelial growth factor promoter single nucleotide polymorphisms (−152G>A and −165C>T) and the C1772T single nucleotide polymorphism of hypoxia-inducible factor-1α were performed using polymerase chain reaction and restriction fragment length polymorphism analysis. The presence and extent of collateral vessel filling was scored by blinded observers using the Rentrop grade. Results: We found no association between the vascular endothelial growth factor −152G>A, −165C>T and hypoxia-inducible factor-1α −1772C>T with the presence and filling of coronary collateral vessels. A history of percutaneous coronary intervention and transient ischaemic attack/cerebrovascular accident were associated with the presence of enhanced collateral vessel formation following binary logistic regression analysis. Conclusion: The study findings suggest that coronary collateral formation is not associated with the tested polymorphic variants of vascular endothelial growth factor and hypoxia-inducible factor-1α in patients with symptomatic coronary artery disease and the presence of a chronic total occlusion.https://doi.org/10.1177/2050312116654403 |
| spellingShingle | Vincent Amoah Benjamin Wrigley Eric Holroyd Andrew Smallwood Angel L Armesilla Alan Nevill James Cotton Vascular endothelial growth factor and hypoxia-inducible factor-1α gene polymorphisms and coronary collateral formation in patients with coronary chronic total occlusions SAGE Open Medicine |
| title | Vascular endothelial growth factor and hypoxia-inducible factor-1α gene polymorphisms and coronary collateral formation in patients with coronary chronic total occlusions |
| title_full | Vascular endothelial growth factor and hypoxia-inducible factor-1α gene polymorphisms and coronary collateral formation in patients with coronary chronic total occlusions |
| title_fullStr | Vascular endothelial growth factor and hypoxia-inducible factor-1α gene polymorphisms and coronary collateral formation in patients with coronary chronic total occlusions |
| title_full_unstemmed | Vascular endothelial growth factor and hypoxia-inducible factor-1α gene polymorphisms and coronary collateral formation in patients with coronary chronic total occlusions |
| title_short | Vascular endothelial growth factor and hypoxia-inducible factor-1α gene polymorphisms and coronary collateral formation in patients with coronary chronic total occlusions |
| title_sort | vascular endothelial growth factor and hypoxia inducible factor 1α gene polymorphisms and coronary collateral formation in patients with coronary chronic total occlusions |
| url | https://doi.org/10.1177/2050312116654403 |
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