Anthracycline-induced cardiotoxicity: mechanisms, monitoring, and prevention
Anthracyclines are the most fundamental and important treatment of several cancers especially for lymphoma and breast cancer. However, their use is limited by a dose-dependent cardiotoxicity which may emerge early at the initiation of anthracycline administration or several years after termination o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1242596/full |
| _version_ | 1827579480400461824 |
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| author | Yun Qiu Piao Jiang Piao Jiang Yingmei Huang |
| author_facet | Yun Qiu Piao Jiang Piao Jiang Yingmei Huang |
| author_sort | Yun Qiu |
| collection | DOAJ |
| description | Anthracyclines are the most fundamental and important treatment of several cancers especially for lymphoma and breast cancer. However, their use is limited by a dose-dependent cardiotoxicity which may emerge early at the initiation of anthracycline administration or several years after termination of the therapy. A full comprehending of the mechanisms of anthracycline-induced cardiotoxicity, which has not been achieved and is currently under the efforts, is critical to the advance of developing effective methods to protect against the cardiotoxicity, as well as to early detect and treat it. Therefore, we review the recent progress of the mechanism underlying anthracycline-induced cardiotoxicity, as well as approaches to monitor and prevent this issue. |
| first_indexed | 2024-03-08T22:02:25Z |
| format | Article |
| id | doaj.art-b3b1990f9688482a89d273029ec0fba7 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-08T22:02:25Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-b3b1990f9688482a89d273029ec0fba72023-12-19T11:04:27ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-12-011010.3389/fcvm.2023.12425961242596Anthracycline-induced cardiotoxicity: mechanisms, monitoring, and preventionYun Qiu0Piao Jiang1Piao Jiang2Yingmei Huang3Department of Cardiology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Oncology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaThe First Clinical Medical College, Nanchang University, Nanchang, ChinaDepartment of Cardiology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaAnthracyclines are the most fundamental and important treatment of several cancers especially for lymphoma and breast cancer. However, their use is limited by a dose-dependent cardiotoxicity which may emerge early at the initiation of anthracycline administration or several years after termination of the therapy. A full comprehending of the mechanisms of anthracycline-induced cardiotoxicity, which has not been achieved and is currently under the efforts, is critical to the advance of developing effective methods to protect against the cardiotoxicity, as well as to early detect and treat it. Therefore, we review the recent progress of the mechanism underlying anthracycline-induced cardiotoxicity, as well as approaches to monitor and prevent this issue.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1242596/fullanthracyclinecardiotoxicitymechanismsmonitoringprevention |
| spellingShingle | Yun Qiu Piao Jiang Piao Jiang Yingmei Huang Anthracycline-induced cardiotoxicity: mechanisms, monitoring, and prevention Frontiers in Cardiovascular Medicine anthracycline cardiotoxicity mechanisms monitoring prevention |
| title | Anthracycline-induced cardiotoxicity: mechanisms, monitoring, and prevention |
| title_full | Anthracycline-induced cardiotoxicity: mechanisms, monitoring, and prevention |
| title_fullStr | Anthracycline-induced cardiotoxicity: mechanisms, monitoring, and prevention |
| title_full_unstemmed | Anthracycline-induced cardiotoxicity: mechanisms, monitoring, and prevention |
| title_short | Anthracycline-induced cardiotoxicity: mechanisms, monitoring, and prevention |
| title_sort | anthracycline induced cardiotoxicity mechanisms monitoring and prevention |
| topic | anthracycline cardiotoxicity mechanisms monitoring prevention |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1242596/full |
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