Efficacy of fractional carbon dioxide laser therapy for burn scars: a meta-analysis

Background The present study evaluates the effectiveness of fractional carbon dioxide (CO2) laser for the treatment of burn scars. Method Literature search was conducted in electronic databases and studies were selected by following pre-determined eligibility criteria. Random effect meta-analyses we...

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Main Authors: Cong Zhang, Kai Yin, Yu-ming Shen
Format: Article
Language:English
Published: Taylor & Francis Group 2021-10-01
Series:Journal of Dermatological Treatment
Subjects:
Online Access:http://dx.doi.org/10.1080/09546634.2019.1704679
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author Cong Zhang
Kai Yin
Yu-ming Shen
author_facet Cong Zhang
Kai Yin
Yu-ming Shen
author_sort Cong Zhang
collection DOAJ
description Background The present study evaluates the effectiveness of fractional carbon dioxide (CO2) laser for the treatment of burn scars. Method Literature search was conducted in electronic databases and studies were selected by following pre-determined eligibility criteria. Random effect meta-analyses were performed to achieve the effect size of the changes (mean difference (MD) between post-treatment and pretreatment values) in selected scar assessment scale scores and other important outcome measures. Results 14 studies were included. Treatment of burn scars with fractional CO2 laser significantly improved Vancouver Scar Scale (MD −3.01 [95% confidence interval (CI) −3.79, −2.22]; p ˂ .00001), Patient and Observer Scar Assessment Scale (POSAS)– Patient (MD −14.38 [95% CI −17.62, −11.13]; p ˂ .00001, POSAS – Observer (MD −8.81 [9% CI −11.60, −6.02]; p ˂ .00001 and Scar Assessment Scale (MD 1.64 [95% CI 0.49, 2.78]; p = .005) scores especially with regards to pigmentation, vascularity, pliability, and height of scar. Pain and pruritis also improved with this treatment. Scar thickness measured with ultrasonography decreased non-significantly (MD −0.48 [95% CI −1.04, 0.09]; p = .1) whereas cutometer measures, R0 (scar firmness) and R2 (scar elasticity) did not change meaningfully. Conclusion Fractional CO2 laser therapy is a valuable tool for the treatment of burn scars which has potential for reducing scar severity.
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spelling doaj.art-b3b1bd448bed43ceab9ecc9135fc950d2023-09-15T14:23:04ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532021-10-0132784585010.1080/09546634.2019.17046791704679Efficacy of fractional carbon dioxide laser therapy for burn scars: a meta-analysisCong Zhang0Kai Yin1Yu-ming Shen2Department of Burn, Beijing Jishuitan HospitalDepartment of Burn, Beijing Jishuitan HospitalDepartment of Burn, Beijing Jishuitan HospitalBackground The present study evaluates the effectiveness of fractional carbon dioxide (CO2) laser for the treatment of burn scars. Method Literature search was conducted in electronic databases and studies were selected by following pre-determined eligibility criteria. Random effect meta-analyses were performed to achieve the effect size of the changes (mean difference (MD) between post-treatment and pretreatment values) in selected scar assessment scale scores and other important outcome measures. Results 14 studies were included. Treatment of burn scars with fractional CO2 laser significantly improved Vancouver Scar Scale (MD −3.01 [95% confidence interval (CI) −3.79, −2.22]; p ˂ .00001), Patient and Observer Scar Assessment Scale (POSAS)– Patient (MD −14.38 [95% CI −17.62, −11.13]; p ˂ .00001, POSAS – Observer (MD −8.81 [9% CI −11.60, −6.02]; p ˂ .00001 and Scar Assessment Scale (MD 1.64 [95% CI 0.49, 2.78]; p = .005) scores especially with regards to pigmentation, vascularity, pliability, and height of scar. Pain and pruritis also improved with this treatment. Scar thickness measured with ultrasonography decreased non-significantly (MD −0.48 [95% CI −1.04, 0.09]; p = .1) whereas cutometer measures, R0 (scar firmness) and R2 (scar elasticity) did not change meaningfully. Conclusion Fractional CO2 laser therapy is a valuable tool for the treatment of burn scars which has potential for reducing scar severity.http://dx.doi.org/10.1080/09546634.2019.1704679burn scarshypertrophickeloidalfractional carbon dioxide laser
spellingShingle Cong Zhang
Kai Yin
Yu-ming Shen
Efficacy of fractional carbon dioxide laser therapy for burn scars: a meta-analysis
Journal of Dermatological Treatment
burn scars
hypertrophic
keloidal
fractional carbon dioxide laser
title Efficacy of fractional carbon dioxide laser therapy for burn scars: a meta-analysis
title_full Efficacy of fractional carbon dioxide laser therapy for burn scars: a meta-analysis
title_fullStr Efficacy of fractional carbon dioxide laser therapy for burn scars: a meta-analysis
title_full_unstemmed Efficacy of fractional carbon dioxide laser therapy for burn scars: a meta-analysis
title_short Efficacy of fractional carbon dioxide laser therapy for burn scars: a meta-analysis
title_sort efficacy of fractional carbon dioxide laser therapy for burn scars a meta analysis
topic burn scars
hypertrophic
keloidal
fractional carbon dioxide laser
url http://dx.doi.org/10.1080/09546634.2019.1704679
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AT kaiyin efficacyoffractionalcarbondioxidelasertherapyforburnscarsametaanalysis
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