Ongoing involvers and promising therapeutic targets of hepatic fibrosis: The hepatic immune microenvironment
Hepatic fibrosis is often secondary to chronic inflammatory liver injury. During the development of hepatic fibrosis, the damaged hepatocytes and activated hepatic stellate cells (HSCs) caused by the pathogenic injury could secrete a variety of cytokines and chemokines, which will chemotactic innate...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1131588/full |
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| author | Nana Zhang Nana Zhang Nana Zhang Huimin Yao Huimin Yao Huimin Yao Zhixuan Zhang Zhixuan Zhang Zhixuan Zhang Zhuoqun Li Zhuoqun Li Zhuoqun Li Xue Chen Xue Chen Yan Zhao Yan Zhao Yan Zhao Ran Ju Ran Ju Ran Ju Jiayi He Jiayi He Jiayi He Heli Pan Heli Pan Heli Pan Xiaoli Liu Xiaoli Liu Xiaoli Liu Yi Lv Yi Lv Yi Lv Yi Lv |
| author_facet | Nana Zhang Nana Zhang Nana Zhang Huimin Yao Huimin Yao Huimin Yao Zhixuan Zhang Zhixuan Zhang Zhixuan Zhang Zhuoqun Li Zhuoqun Li Zhuoqun Li Xue Chen Xue Chen Yan Zhao Yan Zhao Yan Zhao Ran Ju Ran Ju Ran Ju Jiayi He Jiayi He Jiayi He Heli Pan Heli Pan Heli Pan Xiaoli Liu Xiaoli Liu Xiaoli Liu Yi Lv Yi Lv Yi Lv Yi Lv |
| author_sort | Nana Zhang |
| collection | DOAJ |
| description | Hepatic fibrosis is often secondary to chronic inflammatory liver injury. During the development of hepatic fibrosis, the damaged hepatocytes and activated hepatic stellate cells (HSCs) caused by the pathogenic injury could secrete a variety of cytokines and chemokines, which will chemotactic innate and adaptive immune cells of liver tissue and peripheral circulation infiltrating into the injury site, mediating the immune response against injury and promoting tissue reparation. However, the continuous release of persistent injurious stimulus-induced inflammatory cytokines will promote HSCs-mediated fibrous tissue hyperproliferation and excessive repair, which will cause hepatic fibrosis development and progression to cirrhosis even liver cancer. And the activated HSCs can secrete various cytokines and chemokines, which directly interact with immune cells and actively participate in liver disease progression. Therefore, analyzing the changes in local immune homeostasis caused by immune response under different pathological states will greatly enrich our understanding of liver diseases’ reversal, chronicity, progression, and even deterioration of liver cancer. In this review, we summarized the critical components of the hepatic immune microenvironment (HIME), different sub-type immune cells, and their released cytokines, according to their effect on the development of progression of hepatic fibrosis. And we also reviewed and analyzed the specific changes and the related mechanisms of the immune microenvironment in different chronic liver diseases.Moreover, we retrospectively analyzed whether the progression of hepatic fibrosis could be alleviated by modulating the HIME.We aimed to elucidate the pathogenesis of hepatic fibrosis and provide the possibility for exploring the therapeutic targets for hepatic fibrosis. |
| first_indexed | 2024-04-10T09:59:08Z |
| format | Article |
| id | doaj.art-b3b2060aa7d1471ea6c489035cf3f996 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T09:59:08Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b3b2060aa7d1471ea6c489035cf3f9962023-02-16T10:17:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.11315881131588Ongoing involvers and promising therapeutic targets of hepatic fibrosis: The hepatic immune microenvironmentNana Zhang0Nana Zhang1Nana Zhang2Huimin Yao3Huimin Yao4Huimin Yao5Zhixuan Zhang6Zhixuan Zhang7Zhixuan Zhang8Zhuoqun Li9Zhuoqun Li10Zhuoqun Li11Xue Chen12Xue Chen13Yan Zhao14Yan Zhao15Yan Zhao16Ran Ju17Ran Ju18Ran Ju19Jiayi He20Jiayi He21Jiayi He22Heli Pan23Heli Pan24Heli Pan25Xiaoli Liu26Xiaoli Liu27Xiaoli Liu28Yi Lv29Yi Lv30Yi Lv31Yi Lv32Institute of Regenerative and Reconstructive Medicine, Med-X Institute, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaNational Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaShaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaInstitute of Regenerative and Reconstructive Medicine, Med-X Institute, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaNational Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaShaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaInstitute of Regenerative and Reconstructive Medicine, Med-X Institute, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaNational Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaShaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaNational Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaShaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaNational Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaShaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaInstitute of Regenerative and Reconstructive Medicine, Med-X Institute, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaNational Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaShaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaInstitute of Regenerative and Reconstructive Medicine, Med-X Institute, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaNational Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaShaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaInstitute of Regenerative and Reconstructive Medicine, Med-X Institute, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaNational Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaShaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaInstitute of Regenerative and Reconstructive Medicine, Med-X Institute, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaNational Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaShaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaInstitute of Regenerative and Reconstructive Medicine, Med-X Institute, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaNational Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaShaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaInstitute of Regenerative and Reconstructive Medicine, Med-X Institute, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaNational Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaShaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaHepatic fibrosis is often secondary to chronic inflammatory liver injury. During the development of hepatic fibrosis, the damaged hepatocytes and activated hepatic stellate cells (HSCs) caused by the pathogenic injury could secrete a variety of cytokines and chemokines, which will chemotactic innate and adaptive immune cells of liver tissue and peripheral circulation infiltrating into the injury site, mediating the immune response against injury and promoting tissue reparation. However, the continuous release of persistent injurious stimulus-induced inflammatory cytokines will promote HSCs-mediated fibrous tissue hyperproliferation and excessive repair, which will cause hepatic fibrosis development and progression to cirrhosis even liver cancer. And the activated HSCs can secrete various cytokines and chemokines, which directly interact with immune cells and actively participate in liver disease progression. Therefore, analyzing the changes in local immune homeostasis caused by immune response under different pathological states will greatly enrich our understanding of liver diseases’ reversal, chronicity, progression, and even deterioration of liver cancer. In this review, we summarized the critical components of the hepatic immune microenvironment (HIME), different sub-type immune cells, and their released cytokines, according to their effect on the development of progression of hepatic fibrosis. And we also reviewed and analyzed the specific changes and the related mechanisms of the immune microenvironment in different chronic liver diseases.Moreover, we retrospectively analyzed whether the progression of hepatic fibrosis could be alleviated by modulating the HIME.We aimed to elucidate the pathogenesis of hepatic fibrosis and provide the possibility for exploring the therapeutic targets for hepatic fibrosis.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1131588/fullhepatic fibrosishepatic immune microenvironmentchronic liver diseaseshepatic stellate cells (HSCs)immune cells |
| spellingShingle | Nana Zhang Nana Zhang Nana Zhang Huimin Yao Huimin Yao Huimin Yao Zhixuan Zhang Zhixuan Zhang Zhixuan Zhang Zhuoqun Li Zhuoqun Li Zhuoqun Li Xue Chen Xue Chen Yan Zhao Yan Zhao Yan Zhao Ran Ju Ran Ju Ran Ju Jiayi He Jiayi He Jiayi He Heli Pan Heli Pan Heli Pan Xiaoli Liu Xiaoli Liu Xiaoli Liu Yi Lv Yi Lv Yi Lv Yi Lv Ongoing involvers and promising therapeutic targets of hepatic fibrosis: The hepatic immune microenvironment Frontiers in Immunology hepatic fibrosis hepatic immune microenvironment chronic liver diseases hepatic stellate cells (HSCs) immune cells |
| title | Ongoing involvers and promising therapeutic targets of hepatic fibrosis: The hepatic immune microenvironment |
| title_full | Ongoing involvers and promising therapeutic targets of hepatic fibrosis: The hepatic immune microenvironment |
| title_fullStr | Ongoing involvers and promising therapeutic targets of hepatic fibrosis: The hepatic immune microenvironment |
| title_full_unstemmed | Ongoing involvers and promising therapeutic targets of hepatic fibrosis: The hepatic immune microenvironment |
| title_short | Ongoing involvers and promising therapeutic targets of hepatic fibrosis: The hepatic immune microenvironment |
| title_sort | ongoing involvers and promising therapeutic targets of hepatic fibrosis the hepatic immune microenvironment |
| topic | hepatic fibrosis hepatic immune microenvironment chronic liver diseases hepatic stellate cells (HSCs) immune cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1131588/full |
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