Crucial Roles of the RIP Homotypic Interaction Motifs of RIPK3 in RIPK1-Dependent Cell Death and Lymphoproliferative Disease

Crucial Roles of the RIP Homotypic Interaction Motifs of RIPK3 in RIPK1-Dependent Cell Death and Lymphoproliferative Disease

Summary: Receptor-interacting protein kinase 3 (RIPK3) has been identified as an essential regulator of necroptosis, apoptosis, and inflammatory signaling. RIPK3 contains an N-terminal kinase domain and a C-terminal RIP homotypic interaction motif (RHIM). However, the physiological roles of RIPK3 RH...

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Bibliographic Details
Main Authors: Haiwei Zhang, Xiaoxia Wu, Xiaoming Li, Ming Li, Fang Li, Lingxia Wang, Xixi Zhang, Yue Zhang, Yan Luo, Hui Wang, Yiguo Jiang, Haibing Zhang
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
RIPK3
RIPK1
necroptosis
Receptor-interacting protein homotypic interaction motifs
RHIM
lymphoproliferative disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306033

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