Characteristics of alpha-fetoprotein-positive gastric cancer revealed by analysis of cancer databases and transcriptome sequencing data
Gastric cancer is one of the most common malignant tumors in the world. Alpha fetoprotein (AFP)-positive gastric cancer (AFPP-GC) is considered a special entity among gastric cancers. There is still controversy regarding the clinicopathological characteristics and prognosis of AFPP-GC, and the poten...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
|
| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523323001237 |
| _version_ | 1797745997088030720 |
|---|---|
| author | Yansen Li Yilin Lin Long Zhao Changjiang Yang Bo Wang Zhidong Gao Yingjiang Ye Shan Wang Zhanlong Shen |
| author_facet | Yansen Li Yilin Lin Long Zhao Changjiang Yang Bo Wang Zhidong Gao Yingjiang Ye Shan Wang Zhanlong Shen |
| author_sort | Yansen Li |
| collection | DOAJ |
| description | Gastric cancer is one of the most common malignant tumors in the world. Alpha fetoprotein (AFP)-positive gastric cancer (AFPP-GC) is considered a special entity among gastric cancers. There is still controversy regarding the clinicopathological characteristics and prognosis of AFPP-GC, and the potential mechanism underlying its high malignant potential is still unclear. A comprehensive description of AFPP-GC genomic characteristics and regulatory mechanisms is lacking. This study analyzed the pathological characteristics and prognosis of AFPP-GC by utilizing clinical samples. The results showed that AFPP-GC has a poor prognosis and a high of risk liver metastasis. Tissue transcriptome sequencing showed that genes with high expression in AFPP-GC were involved in the activation of various cancer pathways, and genes with low expression were involved in the immune response. Single-sample gene set enrichment analysis showed that overexpression of AFP in AFPP-GC significantly inhibited the infiltration of CD8+ T cells. To further explore the genomic characteristics of AFPP-GC, the signaling pathway by which AFP regulates the invasion and metastasis of AFPP-GC cells was discussed. The results showed that AFPP-GC may promote cell invasion by regulating the PTEN/AKT1/SOX5/CES1 signaling axis. This study reveals the molecular mechanism underlying the increased malignant potential of AFPP-GC vs. AFP-negative gastric cancer (AFPN-GC). This provides important information for individualized treatment of AFPP-GC. |
| first_indexed | 2024-03-12T15:31:46Z |
| format | Article |
| id | doaj.art-b3b30a6072da42a7a4d69e557d6b5f09 |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-03-12T15:31:46Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-b3b30a6072da42a7a4d69e557d6b5f092023-08-10T04:34:06ZengElsevierTranslational Oncology1936-52332023-10-0136101737Characteristics of alpha-fetoprotein-positive gastric cancer revealed by analysis of cancer databases and transcriptome sequencing dataYansen Li0Yilin Lin1Long Zhao2Changjiang Yang3Bo Wang4Zhidong Gao5Yingjiang Ye6Shan Wang7Zhanlong Shen8Department of Gastroenterological Surgery, Peking University People's Hospital, Beijing, China.; Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People's Hospital, Beijing, China; Department of General Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.Department of Gastroenterological Surgery, Peking University People's Hospital, Beijing, China.; Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People's Hospital, Beijing, ChinaDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing, China.; Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People's Hospital, Beijing, ChinaDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing, China.; Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People's Hospital, Beijing, ChinaDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing, China.; Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People's Hospital, Beijing, ChinaDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing, China.; Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People's Hospital, Beijing, ChinaDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing, China.; Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People's Hospital, Beijing, ChinaDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing, China.; Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People's Hospital, Beijing, ChinaDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing, China.; Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People's Hospital, Beijing, China; Corresponding author.Gastric cancer is one of the most common malignant tumors in the world. Alpha fetoprotein (AFP)-positive gastric cancer (AFPP-GC) is considered a special entity among gastric cancers. There is still controversy regarding the clinicopathological characteristics and prognosis of AFPP-GC, and the potential mechanism underlying its high malignant potential is still unclear. A comprehensive description of AFPP-GC genomic characteristics and regulatory mechanisms is lacking. This study analyzed the pathological characteristics and prognosis of AFPP-GC by utilizing clinical samples. The results showed that AFPP-GC has a poor prognosis and a high of risk liver metastasis. Tissue transcriptome sequencing showed that genes with high expression in AFPP-GC were involved in the activation of various cancer pathways, and genes with low expression were involved in the immune response. Single-sample gene set enrichment analysis showed that overexpression of AFP in AFPP-GC significantly inhibited the infiltration of CD8+ T cells. To further explore the genomic characteristics of AFPP-GC, the signaling pathway by which AFP regulates the invasion and metastasis of AFPP-GC cells was discussed. The results showed that AFPP-GC may promote cell invasion by regulating the PTEN/AKT1/SOX5/CES1 signaling axis. This study reveals the molecular mechanism underlying the increased malignant potential of AFPP-GC vs. AFP-negative gastric cancer (AFPN-GC). This provides important information for individualized treatment of AFPP-GC.http://www.sciencedirect.com/science/article/pii/S1936523323001237Alpha fetoprotein-positive gastric cancerGenomic characteristicsTumor microenvironmentPrognosis |
| spellingShingle | Yansen Li Yilin Lin Long Zhao Changjiang Yang Bo Wang Zhidong Gao Yingjiang Ye Shan Wang Zhanlong Shen Characteristics of alpha-fetoprotein-positive gastric cancer revealed by analysis of cancer databases and transcriptome sequencing data Translational Oncology Alpha fetoprotein-positive gastric cancer Genomic characteristics Tumor microenvironment Prognosis |
| title | Characteristics of alpha-fetoprotein-positive gastric cancer revealed by analysis of cancer databases and transcriptome sequencing data |
| title_full | Characteristics of alpha-fetoprotein-positive gastric cancer revealed by analysis of cancer databases and transcriptome sequencing data |
| title_fullStr | Characteristics of alpha-fetoprotein-positive gastric cancer revealed by analysis of cancer databases and transcriptome sequencing data |
| title_full_unstemmed | Characteristics of alpha-fetoprotein-positive gastric cancer revealed by analysis of cancer databases and transcriptome sequencing data |
| title_short | Characteristics of alpha-fetoprotein-positive gastric cancer revealed by analysis of cancer databases and transcriptome sequencing data |
| title_sort | characteristics of alpha fetoprotein positive gastric cancer revealed by analysis of cancer databases and transcriptome sequencing data |
| topic | Alpha fetoprotein-positive gastric cancer Genomic characteristics Tumor microenvironment Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S1936523323001237 |
| work_keys_str_mv | AT yansenli characteristicsofalphafetoproteinpositivegastriccancerrevealedbyanalysisofcancerdatabasesandtranscriptomesequencingdata AT yilinlin characteristicsofalphafetoproteinpositivegastriccancerrevealedbyanalysisofcancerdatabasesandtranscriptomesequencingdata AT longzhao characteristicsofalphafetoproteinpositivegastriccancerrevealedbyanalysisofcancerdatabasesandtranscriptomesequencingdata AT changjiangyang characteristicsofalphafetoproteinpositivegastriccancerrevealedbyanalysisofcancerdatabasesandtranscriptomesequencingdata AT bowang characteristicsofalphafetoproteinpositivegastriccancerrevealedbyanalysisofcancerdatabasesandtranscriptomesequencingdata AT zhidonggao characteristicsofalphafetoproteinpositivegastriccancerrevealedbyanalysisofcancerdatabasesandtranscriptomesequencingdata AT yingjiangye characteristicsofalphafetoproteinpositivegastriccancerrevealedbyanalysisofcancerdatabasesandtranscriptomesequencingdata AT shanwang characteristicsofalphafetoproteinpositivegastriccancerrevealedbyanalysisofcancerdatabasesandtranscriptomesequencingdata AT zhanlongshen characteristicsofalphafetoproteinpositivegastriccancerrevealedbyanalysisofcancerdatabasesandtranscriptomesequencingdata |