Increased serum anti-N-methyl-D-aspartate receptor antibody immunofluorescence in psychiatric patients with past catatonia.
Anti-N-methyl-D-aspartate receptor (NMDAR) antibody was thought to be the cause of anti-NMDAR encephalitis, with manifestations similar to catatonia and schizophrenia. Anti-NMDAR antibody in neuropsychiatric patients who had catatonia before were investigated in a follow-up evaluation. The intensity...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5658162?pdf=render |
| _version_ | 1831669158211747840 |
|---|---|
| author | Chin-Chuen Lin Yi-Yung Hung Meng-Chang Tsai Tiao-Lai Huang |
| author_facet | Chin-Chuen Lin Yi-Yung Hung Meng-Chang Tsai Tiao-Lai Huang |
| author_sort | Chin-Chuen Lin |
| collection | DOAJ |
| description | Anti-N-methyl-D-aspartate receptor (NMDAR) antibody was thought to be the cause of anti-NMDAR encephalitis, with manifestations similar to catatonia and schizophrenia. Anti-NMDAR antibody in neuropsychiatric patients who had catatonia before were investigated in a follow-up evaluation. The intensity of antibody immunofluorescence was quantified and compared with healthy controls.Nineteen patients (eight males and eleven females) agreed to be followed-up. Thirteen had the diagnosis of schizophrenia, two had the diagnosis of major depressive disorder, two had bipolar disorder, one had postpartum depression, and one had herpes simplex encephalitis. No patient had catatonia during the follow-up. Nineteen sex-matched healthy controls were recruited.Using Mann-Whitney U test, patients had greater intensity of anti-NMDAR antibody immunofluorescence than the healthy controls (121,979 ± 86,526 vs. 47,692 ± 26,102, p = 0.003). No correlation was found between immunofluorescence intensity and catatonia scales or symptom severity scores. Neuropsychiatric patients with past catatonia showed greater anti-NMDAR antibody response than the healthy controls.NMDAR dysfunction might play a role in the mechanism underlying catatonia. Further studies are needed to confirm this finding. |
| first_indexed | 2024-12-19T22:54:05Z |
| format | Article |
| id | doaj.art-b3b3b84fe1d4441cb88a74498f93162d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T22:54:05Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b3b3b84fe1d4441cb88a74498f93162d2022-12-21T20:02:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011210e018715610.1371/journal.pone.0187156Increased serum anti-N-methyl-D-aspartate receptor antibody immunofluorescence in psychiatric patients with past catatonia.Chin-Chuen LinYi-Yung HungMeng-Chang TsaiTiao-Lai HuangAnti-N-methyl-D-aspartate receptor (NMDAR) antibody was thought to be the cause of anti-NMDAR encephalitis, with manifestations similar to catatonia and schizophrenia. Anti-NMDAR antibody in neuropsychiatric patients who had catatonia before were investigated in a follow-up evaluation. The intensity of antibody immunofluorescence was quantified and compared with healthy controls.Nineteen patients (eight males and eleven females) agreed to be followed-up. Thirteen had the diagnosis of schizophrenia, two had the diagnosis of major depressive disorder, two had bipolar disorder, one had postpartum depression, and one had herpes simplex encephalitis. No patient had catatonia during the follow-up. Nineteen sex-matched healthy controls were recruited.Using Mann-Whitney U test, patients had greater intensity of anti-NMDAR antibody immunofluorescence than the healthy controls (121,979 ± 86,526 vs. 47,692 ± 26,102, p = 0.003). No correlation was found between immunofluorescence intensity and catatonia scales or symptom severity scores. Neuropsychiatric patients with past catatonia showed greater anti-NMDAR antibody response than the healthy controls.NMDAR dysfunction might play a role in the mechanism underlying catatonia. Further studies are needed to confirm this finding.http://europepmc.org/articles/PMC5658162?pdf=render |
| spellingShingle | Chin-Chuen Lin Yi-Yung Hung Meng-Chang Tsai Tiao-Lai Huang Increased serum anti-N-methyl-D-aspartate receptor antibody immunofluorescence in psychiatric patients with past catatonia. PLoS ONE |
| title | Increased serum anti-N-methyl-D-aspartate receptor antibody immunofluorescence in psychiatric patients with past catatonia. |
| title_full | Increased serum anti-N-methyl-D-aspartate receptor antibody immunofluorescence in psychiatric patients with past catatonia. |
| title_fullStr | Increased serum anti-N-methyl-D-aspartate receptor antibody immunofluorescence in psychiatric patients with past catatonia. |
| title_full_unstemmed | Increased serum anti-N-methyl-D-aspartate receptor antibody immunofluorescence in psychiatric patients with past catatonia. |
| title_short | Increased serum anti-N-methyl-D-aspartate receptor antibody immunofluorescence in psychiatric patients with past catatonia. |
| title_sort | increased serum anti n methyl d aspartate receptor antibody immunofluorescence in psychiatric patients with past catatonia |
| url | http://europepmc.org/articles/PMC5658162?pdf=render |
| work_keys_str_mv | AT chinchuenlin increasedserumantinmethyldaspartatereceptorantibodyimmunofluorescenceinpsychiatricpatientswithpastcatatonia AT yiyunghung increasedserumantinmethyldaspartatereceptorantibodyimmunofluorescenceinpsychiatricpatientswithpastcatatonia AT mengchangtsai increasedserumantinmethyldaspartatereceptorantibodyimmunofluorescenceinpsychiatricpatientswithpastcatatonia AT tiaolaihuang increasedserumantinmethyldaspartatereceptorantibodyimmunofluorescenceinpsychiatricpatientswithpastcatatonia |