Gut Microbiota, the Potential Biological Medicine for Prevention, Intervention and Drug Sensitization to Fight Diseases
As the largest “immune organ” of human beings, the gut microbiota is symbiotic and mutually beneficial with the human host, playing multiple physiological functions. Studies have long shown that dysbiosis of gut microbiota is associated with almost all human diseases, mainly including type II diabet...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/20/4220 |
| _version_ | 1797470696560918528 |
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| author | Haijie Wu Xiaoguang Chen Sen Zhang Jiaxin Li |
| author_facet | Haijie Wu Xiaoguang Chen Sen Zhang Jiaxin Li |
| author_sort | Haijie Wu |
| collection | DOAJ |
| description | As the largest “immune organ” of human beings, the gut microbiota is symbiotic and mutually beneficial with the human host, playing multiple physiological functions. Studies have long shown that dysbiosis of gut microbiota is associated with almost all human diseases, mainly including type II diabetes, cancers, neurodegenerative diseases, autism spectrum disorder, and kidney diseases. As a novel and potential biological medicine for disease prevention, intervention and drug sensitization, the gut microbiota has attracted more and more attention recently. Although the gut microbiota is a comprehensive microbial community, several star bacteria have emerged as possible tools to fight against various diseases. This review aims to elucidate the relevance of gut microbiota dysbiosis with disease occurrence and progression, and mainly summarizes four well-known genera with therapeutic and sensitizing potential, <i>Akkermansia</i>, <i>Bifidobacterium</i>, <i>Lactobacillus</i> and <i>Parabacteroides</i>, thoroughly elucidate their potential value as biological drugs to treat diverse disease. |
| first_indexed | 2024-03-09T19:39:43Z |
| format | Article |
| id | doaj.art-b3b444aa7c814233ac828a76e2967106 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T19:39:43Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-b3b444aa7c814233ac828a76e29671062023-11-24T01:42:39ZengMDPI AGNutrients2072-66432022-10-011420422010.3390/nu14204220Gut Microbiota, the Potential Biological Medicine for Prevention, Intervention and Drug Sensitization to Fight DiseasesHaijie Wu0Xiaoguang Chen1Sen Zhang2Jiaxin Li3State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, ChinaDepartment of Gastrointestinal Surgery, The Sixth Affiliated Hospital of Wenzhou Medical University & Lishui City People’s Hospital, Lishui 323000, ChinaAs the largest “immune organ” of human beings, the gut microbiota is symbiotic and mutually beneficial with the human host, playing multiple physiological functions. Studies have long shown that dysbiosis of gut microbiota is associated with almost all human diseases, mainly including type II diabetes, cancers, neurodegenerative diseases, autism spectrum disorder, and kidney diseases. As a novel and potential biological medicine for disease prevention, intervention and drug sensitization, the gut microbiota has attracted more and more attention recently. Although the gut microbiota is a comprehensive microbial community, several star bacteria have emerged as possible tools to fight against various diseases. This review aims to elucidate the relevance of gut microbiota dysbiosis with disease occurrence and progression, and mainly summarizes four well-known genera with therapeutic and sensitizing potential, <i>Akkermansia</i>, <i>Bifidobacterium</i>, <i>Lactobacillus</i> and <i>Parabacteroides</i>, thoroughly elucidate their potential value as biological drugs to treat diverse disease.https://www.mdpi.com/2072-6643/14/20/4220gut microbiota<i>Akkermansia</i><i>Bifidobacterium</i><i>Lactobacillus</i><i>Parabacteroides</i>cancer |
| spellingShingle | Haijie Wu Xiaoguang Chen Sen Zhang Jiaxin Li Gut Microbiota, the Potential Biological Medicine for Prevention, Intervention and Drug Sensitization to Fight Diseases Nutrients gut microbiota <i>Akkermansia</i> <i>Bifidobacterium</i> <i>Lactobacillus</i> <i>Parabacteroides</i> cancer |
| title | Gut Microbiota, the Potential Biological Medicine for Prevention, Intervention and Drug Sensitization to Fight Diseases |
| title_full | Gut Microbiota, the Potential Biological Medicine for Prevention, Intervention and Drug Sensitization to Fight Diseases |
| title_fullStr | Gut Microbiota, the Potential Biological Medicine for Prevention, Intervention and Drug Sensitization to Fight Diseases |
| title_full_unstemmed | Gut Microbiota, the Potential Biological Medicine for Prevention, Intervention and Drug Sensitization to Fight Diseases |
| title_short | Gut Microbiota, the Potential Biological Medicine for Prevention, Intervention and Drug Sensitization to Fight Diseases |
| title_sort | gut microbiota the potential biological medicine for prevention intervention and drug sensitization to fight diseases |
| topic | gut microbiota <i>Akkermansia</i> <i>Bifidobacterium</i> <i>Lactobacillus</i> <i>Parabacteroides</i> cancer |
| url | https://www.mdpi.com/2072-6643/14/20/4220 |
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