Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir
The aim of the present study is to quantitatively assess the expression of selected regulatory molecules, such as leptin, leptin receptor, and adiponectin in the blood of obese patients with type 2 diabetes both before treatment and after six months of pharmacological therapy with the long-lasting i...
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MDPI AG
2017-07-01
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| Online Access: | https://www.mdpi.com/1420-3049/22/8/1274 |
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| author | Paweł Olczyk Robert Koprowski Katarzyna Komosinska-Vassev Agnieszka Jura-Półtorak Katarzyna Winsz-Szczotka Kornelia Kuźnik-Trocha Łukasz Mencner Alicja Telega Diana Ivanova Krystyna Olczyk |
| author_facet | Paweł Olczyk Robert Koprowski Katarzyna Komosinska-Vassev Agnieszka Jura-Półtorak Katarzyna Winsz-Szczotka Kornelia Kuźnik-Trocha Łukasz Mencner Alicja Telega Diana Ivanova Krystyna Olczyk |
| author_sort | Paweł Olczyk |
| collection | DOAJ |
| description | The aim of the present study is to quantitatively assess the expression of selected regulatory molecules, such as leptin, leptin receptor, and adiponectin in the blood of obese patients with type 2 diabetes both before treatment and after six months of pharmacological therapy with the long-lasting insulin analogue, insulin detemir. A significant decrease in the analysed regulatory molecules, i.e., leptin receptor and adiponectin, was found in blood plasma of the patients with untreated type 2 diabetes. These changes were accompanied by an increase in plasma leptin concentrations. Insulin treatment resulted in the normalization of plasma leptin receptor and adiponectin concentrations. The circulating leptin level did not change following anti-diabetic therapy with insulin detemir. Gender was a significant factor modifying the circulating level of all the analysed regulatory active compounds. Bioinformatic analysis was performed using Matlab with the Signal Processing Toolbox. The conducted discriminant analysis revealed that the leptin receptor, Δw(19), and adiponectin, Δw(21), were the parameters undergoing the most significant quantitative changes during the six-month therapy with insulin detemir. The conducted examinations indicated the contribution of adipocytokines—the biologically-active mediators of systemic metabolism, such as leptin and adiponectin in the pathomechanism of disorders being the basis for obesity which leads to development of insulin resistance, which, in turn, results in the occurrence of type 2 diabetes. |
| first_indexed | 2024-12-14T14:59:34Z |
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| id | doaj.art-b3b46d2004424ce19f50dcd110a810b8 |
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| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-14T14:59:34Z |
| publishDate | 2017-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b3b46d2004424ce19f50dcd110a810b82022-12-21T22:56:52ZengMDPI AGMolecules1420-30492017-07-01228127410.3390/molecules22081274molecules22081274Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin DetemirPaweł Olczyk0Robert Koprowski1Katarzyna Komosinska-Vassev2Agnieszka Jura-Półtorak3Katarzyna Winsz-Szczotka4Kornelia Kuźnik-Trocha5Łukasz Mencner6Alicja Telega7Diana Ivanova8Krystyna Olczyk9Department of Community Pharmacy, School of Pharmacy and Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, 41-200 Sosnowiec, PolandDepartment of Biomedical Computer Systems, Faculty of Computer Science and Materials Science, Institute of Computer Science, University of Silesia, 41-200 Sosnowiec, PolandDepartment of Clinical Chemistry and Laboratory Diagnostics, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, 41-200 Sosnowiec, PolandDepartment of Clinical Chemistry and Laboratory Diagnostics, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, 41-200 Sosnowiec, PolandDepartment of Clinical Chemistry and Laboratory Diagnostics, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, 41-200 Sosnowiec, PolandDepartment of Clinical Chemistry and Laboratory Diagnostics, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, 41-200 Sosnowiec, PolandDepartment of Clinical Chemistry and Laboratory Diagnostics, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, 41-200 Sosnowiec, PolandDepartment of Clinical Chemistry and Laboratory Diagnostics, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, 41-200 Sosnowiec, PolandDepartment of Biochemistry, Molecular Medicine and Nutrigenomics, The Faculty of Pharmacy, Medical University of Varna, 9002 Varna, BulgariaDepartment of Clinical Chemistry and Laboratory Diagnostics, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, 41-200 Sosnowiec, PolandThe aim of the present study is to quantitatively assess the expression of selected regulatory molecules, such as leptin, leptin receptor, and adiponectin in the blood of obese patients with type 2 diabetes both before treatment and after six months of pharmacological therapy with the long-lasting insulin analogue, insulin detemir. A significant decrease in the analysed regulatory molecules, i.e., leptin receptor and adiponectin, was found in blood plasma of the patients with untreated type 2 diabetes. These changes were accompanied by an increase in plasma leptin concentrations. Insulin treatment resulted in the normalization of plasma leptin receptor and adiponectin concentrations. The circulating leptin level did not change following anti-diabetic therapy with insulin detemir. Gender was a significant factor modifying the circulating level of all the analysed regulatory active compounds. Bioinformatic analysis was performed using Matlab with the Signal Processing Toolbox. The conducted discriminant analysis revealed that the leptin receptor, Δw(19), and adiponectin, Δw(21), were the parameters undergoing the most significant quantitative changes during the six-month therapy with insulin detemir. The conducted examinations indicated the contribution of adipocytokines—the biologically-active mediators of systemic metabolism, such as leptin and adiponectin in the pathomechanism of disorders being the basis for obesity which leads to development of insulin resistance, which, in turn, results in the occurrence of type 2 diabetes.https://www.mdpi.com/1420-3049/22/8/1274diabetes mellitus type 2adipocytokinesinsulin detemirsignal processingalgorithmMatlab |
| spellingShingle | Paweł Olczyk Robert Koprowski Katarzyna Komosinska-Vassev Agnieszka Jura-Półtorak Katarzyna Winsz-Szczotka Kornelia Kuźnik-Trocha Łukasz Mencner Alicja Telega Diana Ivanova Krystyna Olczyk Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir Molecules diabetes mellitus type 2 adipocytokines insulin detemir signal processing algorithm Matlab |
| title | Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir |
| title_full | Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir |
| title_fullStr | Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir |
| title_full_unstemmed | Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir |
| title_short | Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir |
| title_sort | adiponectin leptin and leptin receptor in obese patients with type 2 diabetes treated with insulin detemir |
| topic | diabetes mellitus type 2 adipocytokines insulin detemir signal processing algorithm Matlab |
| url | https://www.mdpi.com/1420-3049/22/8/1274 |
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