The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression
The pentraxin is a superfamily of proteins with the same domain known as the pentraxin domain at C-terminal. This family has two subgroups, namely; short pentraxins (C-reactive protein and serum amyloid P component) and long pentraxins (neuronal pentraxin 1, neuronal pentraxin 2, neuronal pentraxin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01757/full |
| _version_ | 1818250607084961792 |
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| author | Zeyu Wang Zeyu Wang Xing Wang Hecun Zou Ziyu Dai Songshan Feng Mingyu Zhang Gelei Xiao Zhixiong Liu Zhixiong Liu Quan Cheng Quan Cheng Quan Cheng |
| author_facet | Zeyu Wang Zeyu Wang Xing Wang Hecun Zou Ziyu Dai Songshan Feng Mingyu Zhang Gelei Xiao Zhixiong Liu Zhixiong Liu Quan Cheng Quan Cheng Quan Cheng |
| author_sort | Zeyu Wang |
| collection | DOAJ |
| description | The pentraxin is a superfamily of proteins with the same domain known as the pentraxin domain at C-terminal. This family has two subgroups, namely; short pentraxins (C-reactive protein and serum amyloid P component) and long pentraxins (neuronal pentraxin 1, neuronal pentraxin 2, neuronal pentraxin receptor, pentraxin 3 and pentraxin 4). Each group shares a similar structure with the pentameric complexes arranged in a discoid shape. Previous studies revealed the functions of different pentraxin family members. Most of them are associated with human innate immunity. Inflammation has commonly been associated with tumor progression, implying that the pentraxin family might also participate in tumor progression. Therefore, we reviewed the basic characteristics and functions of the pentraxin family and their role in tumor progression. |
| first_indexed | 2024-12-12T15:55:04Z |
| format | Article |
| id | doaj.art-b3b617f254b941339f952bf9f189c75d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T15:55:04Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b3b617f254b941339f952bf9f189c75d2022-12-22T00:19:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-08-011110.3389/fimmu.2020.01757521261The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor ProgressionZeyu Wang0Zeyu Wang1Xing Wang2Hecun Zou3Ziyu Dai4Songshan Feng5Mingyu Zhang6Gelei Xiao7Zhixiong Liu8Zhixiong Liu9Quan Cheng10Quan Cheng11Quan Cheng12Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Changsha, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Changsha, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaThe pentraxin is a superfamily of proteins with the same domain known as the pentraxin domain at C-terminal. This family has two subgroups, namely; short pentraxins (C-reactive protein and serum amyloid P component) and long pentraxins (neuronal pentraxin 1, neuronal pentraxin 2, neuronal pentraxin receptor, pentraxin 3 and pentraxin 4). Each group shares a similar structure with the pentameric complexes arranged in a discoid shape. Previous studies revealed the functions of different pentraxin family members. Most of them are associated with human innate immunity. Inflammation has commonly been associated with tumor progression, implying that the pentraxin family might also participate in tumor progression. Therefore, we reviewed the basic characteristics and functions of the pentraxin family and their role in tumor progression.https://www.frontiersin.org/article/10.3389/fimmu.2020.01757/fullC-reactive proteinserum amyloid P componentthe long pentraxinspentraxin 3tumor |
| spellingShingle | Zeyu Wang Zeyu Wang Xing Wang Hecun Zou Ziyu Dai Songshan Feng Mingyu Zhang Gelei Xiao Zhixiong Liu Zhixiong Liu Quan Cheng Quan Cheng Quan Cheng The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression Frontiers in Immunology C-reactive protein serum amyloid P component the long pentraxins pentraxin 3 tumor |
| title | The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression |
| title_full | The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression |
| title_fullStr | The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression |
| title_full_unstemmed | The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression |
| title_short | The Basic Characteristics of the Pentraxin Family and Their Functions in Tumor Progression |
| title_sort | basic characteristics of the pentraxin family and their functions in tumor progression |
| topic | C-reactive protein serum amyloid P component the long pentraxins pentraxin 3 tumor |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.01757/full |
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