Is ß-<span style="font-variant: small-caps;">d</span>-glucan Relevant for the Diagnosis and Follow-Up of Intensive Care Patients with Yeast-Complicated Intra-Abdominal Infection?
The usefulness of (1,3)-ß-<span style="font-variant: small-caps;">d</span>-glucan (BDG) detection for the diagnosis of intra-abdominal candidiasis and treatment monitoring is unknown. A prospective, single-center study of consecutive patients admitted to an ICU with complicated...
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| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/8/5/487 |
| _version_ | 1797498691277291520 |
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| author | Hervé Dupont Stéphanie Malaquin Léonie Villeret Pierre-Yves Macq Nacim Ammenouche François Tinturier Momar Diouf Matthieu Rumbach Taieb Chouaki |
| author_facet | Hervé Dupont Stéphanie Malaquin Léonie Villeret Pierre-Yves Macq Nacim Ammenouche François Tinturier Momar Diouf Matthieu Rumbach Taieb Chouaki |
| author_sort | Hervé Dupont |
| collection | DOAJ |
| description | The usefulness of (1,3)-ß-<span style="font-variant: small-caps;">d</span>-glucan (BDG) detection for the diagnosis of intra-abdominal candidiasis and treatment monitoring is unknown. A prospective, single-center study of consecutive patients admitted to an ICU with complicated intra-abdominal infection (IAI) over a 2-year period was conducted. BDG was measured in the peritoneal fluid and serum between day 1 (D1) and D10. Patients with a positive peritoneal fluid yeast culture (YP) were compared to those with a negative yeast culture (YN). The evolution of serum BDG was compared in the two groups. Seventy patients were included (sixty-five analyzed): YP group (n = 19) and YN group (n = 46). Median peritoneal BDG concentration during surgery was 2890 pg.mL<sup>−1</sup> [IQR: 942–12,326] in the YP group vs. 1202 pg.mL<sup>−1</sup> [IQR: 317–4223] in the YN group (<i>p</i> = 0.13). Initial serum BDG concentration was 130 pg.mL<sup>−1</sup> [IQR: 55–259] in the YP group vs. 88 pg.mL<sup>−1</sup> [IQR: 44–296] in the YN group (<i>p</i> = 0.78). No difference in evolution of serum BDG concentrations was observed between the groups (<i>p</i> = 0.18). In conclusion, neither peritoneal BDG nor serum BDG appear to be good discriminating markers for the diagnosis of yeast IAI. In addition, monitoring the evolution of serum BDG in yeast IAI did not appear to be of any diagnostic value. |
| first_indexed | 2024-03-10T03:37:55Z |
| format | Article |
| id | doaj.art-b3b61a4760cc4b859077f36acb157d1a |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T03:37:55Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-b3b61a4760cc4b859077f36acb157d1a2023-11-23T11:41:48ZengMDPI AGJournal of Fungi2309-608X2022-05-018548710.3390/jof8050487Is ß-<span style="font-variant: small-caps;">d</span>-glucan Relevant for the Diagnosis and Follow-Up of Intensive Care Patients with Yeast-Complicated Intra-Abdominal Infection?Hervé Dupont0Stéphanie Malaquin1Léonie Villeret2Pierre-Yves Macq3Nacim Ammenouche4François Tinturier5Momar Diouf6Matthieu Rumbach7Taieb Chouaki8Surgical ICU, Department of Anesthesiology and Critical Care Medicine, University Hospital of Amiens Picardy, 80054 Amiens, FranceSurgical ICU, Department of Anesthesiology and Critical Care Medicine, University Hospital of Amiens Picardy, 80054 Amiens, FranceSurgical ICU, Department of Anesthesiology and Critical Care Medicine, University Hospital of Amiens Picardy, 80054 Amiens, FranceSurgical ICU, Department of Anesthesiology and Critical Care Medicine, University Hospital of Amiens Picardy, 80054 Amiens, FranceSurgical ICU, Department of Anesthesiology and Critical Care Medicine, University Hospital of Amiens Picardy, 80054 Amiens, FranceSurgical ICU, Department of Anesthesiology and Critical Care Medicine, University Hospital of Amiens Picardy, 80054 Amiens, FranceBiostatistical Unit, Direction de la Recherche Clinique, University Hospital of Amiens Picardy, 80054 Amiens, FranceSurgical ICU, Department of Anesthesiology and Critical Care Medicine, University Hospital of Amiens Picardy, 80054 Amiens, FranceMycology Laboratory, University Hospital of Amiens Picardy, 80054 Amiens, FranceThe usefulness of (1,3)-ß-<span style="font-variant: small-caps;">d</span>-glucan (BDG) detection for the diagnosis of intra-abdominal candidiasis and treatment monitoring is unknown. A prospective, single-center study of consecutive patients admitted to an ICU with complicated intra-abdominal infection (IAI) over a 2-year period was conducted. BDG was measured in the peritoneal fluid and serum between day 1 (D1) and D10. Patients with a positive peritoneal fluid yeast culture (YP) were compared to those with a negative yeast culture (YN). The evolution of serum BDG was compared in the two groups. Seventy patients were included (sixty-five analyzed): YP group (n = 19) and YN group (n = 46). Median peritoneal BDG concentration during surgery was 2890 pg.mL<sup>−1</sup> [IQR: 942–12,326] in the YP group vs. 1202 pg.mL<sup>−1</sup> [IQR: 317–4223] in the YN group (<i>p</i> = 0.13). Initial serum BDG concentration was 130 pg.mL<sup>−1</sup> [IQR: 55–259] in the YP group vs. 88 pg.mL<sup>−1</sup> [IQR: 44–296] in the YN group (<i>p</i> = 0.78). No difference in evolution of serum BDG concentrations was observed between the groups (<i>p</i> = 0.18). In conclusion, neither peritoneal BDG nor serum BDG appear to be good discriminating markers for the diagnosis of yeast IAI. In addition, monitoring the evolution of serum BDG in yeast IAI did not appear to be of any diagnostic value.https://www.mdpi.com/2309-608X/8/5/487ß-<span style="font-variant: small-caps;">d</span>-glucanintra-abdominal infectioncandidiasisintensive care unit |
| spellingShingle | Hervé Dupont Stéphanie Malaquin Léonie Villeret Pierre-Yves Macq Nacim Ammenouche François Tinturier Momar Diouf Matthieu Rumbach Taieb Chouaki Is ß-<span style="font-variant: small-caps;">d</span>-glucan Relevant for the Diagnosis and Follow-Up of Intensive Care Patients with Yeast-Complicated Intra-Abdominal Infection? Journal of Fungi ß-<span style="font-variant: small-caps;">d</span>-glucan intra-abdominal infection candidiasis intensive care unit |
| title | Is ß-<span style="font-variant: small-caps;">d</span>-glucan Relevant for the Diagnosis and Follow-Up of Intensive Care Patients with Yeast-Complicated Intra-Abdominal Infection? |
| title_full | Is ß-<span style="font-variant: small-caps;">d</span>-glucan Relevant for the Diagnosis and Follow-Up of Intensive Care Patients with Yeast-Complicated Intra-Abdominal Infection? |
| title_fullStr | Is ß-<span style="font-variant: small-caps;">d</span>-glucan Relevant for the Diagnosis and Follow-Up of Intensive Care Patients with Yeast-Complicated Intra-Abdominal Infection? |
| title_full_unstemmed | Is ß-<span style="font-variant: small-caps;">d</span>-glucan Relevant for the Diagnosis and Follow-Up of Intensive Care Patients with Yeast-Complicated Intra-Abdominal Infection? |
| title_short | Is ß-<span style="font-variant: small-caps;">d</span>-glucan Relevant for the Diagnosis and Follow-Up of Intensive Care Patients with Yeast-Complicated Intra-Abdominal Infection? |
| title_sort | is ss span style font variant small caps d span glucan relevant for the diagnosis and follow up of intensive care patients with yeast complicated intra abdominal infection |
| topic | ß-<span style="font-variant: small-caps;">d</span>-glucan intra-abdominal infection candidiasis intensive care unit |
| url | https://www.mdpi.com/2309-608X/8/5/487 |
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