Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease
This review describes targeting neutrophils as a potential therapeutic strategy for acute respiratory distress syndrome (ARDS) associated with coronavirus disease 2019 (COVID-19), a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Neutrophil counts are significantly e...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2020.572009/full |
| _version_ | 1819205626781237248 |
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| author | Chih-Chao Chiang Chih-Chao Chiang Michal Korinek Michal Korinek Michal Korinek Wei-Jen Cheng Wei-Jen Cheng Wei-Jen Cheng Tsong-Long Hwang Tsong-Long Hwang Tsong-Long Hwang Tsong-Long Hwang Tsong-Long Hwang |
| author_facet | Chih-Chao Chiang Chih-Chao Chiang Michal Korinek Michal Korinek Michal Korinek Wei-Jen Cheng Wei-Jen Cheng Wei-Jen Cheng Tsong-Long Hwang Tsong-Long Hwang Tsong-Long Hwang Tsong-Long Hwang Tsong-Long Hwang |
| author_sort | Chih-Chao Chiang |
| collection | DOAJ |
| description | This review describes targeting neutrophils as a potential therapeutic strategy for acute respiratory distress syndrome (ARDS) associated with coronavirus disease 2019 (COVID-19), a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Neutrophil counts are significantly elevated in patients with COVID-19 and significantly correlated with disease severity. The neutrophil-to-lymphocyte ratio can serve as a clinical marker for predicting fatal complications related to ARDS in patients with COVID-19. Neutrophil-associated inflammation plays a critical pathogenic role in ARDS. The effector functions of neutrophils, acting as respiratory burst oxidants, granule proteases, and neutrophil extracellular traps, are linked to the pathogenesis of ARDS. Hence, neutrophils can not only be used as pathogenic markers but also as candidate drug targets for COVID-19 associated ARDS. |
| first_indexed | 2024-12-23T04:54:42Z |
| format | Article |
| id | doaj.art-b3b8486b388348bb8ce82bfb64432ef5 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-23T04:54:42Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-b3b8486b388348bb8ce82bfb64432ef52022-12-21T17:59:22ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-10-011110.3389/fphar.2020.572009572009Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus DiseaseChih-Chao Chiang0Chih-Chao Chiang1Michal Korinek2Michal Korinek3Michal Korinek4Wei-Jen Cheng5Wei-Jen Cheng6Wei-Jen Cheng7Tsong-Long Hwang8Tsong-Long Hwang9Tsong-Long Hwang10Tsong-Long Hwang11Tsong-Long Hwang12Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanPuxin Fengze Chinese Medicine Clinic, Taoyuan, TaiwanGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, TaiwanResearch Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan, TaiwanDepartment of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, TaiwanGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanSchool of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, TaiwanCenter for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, TaiwanGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, TaiwanResearch Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan, TaiwanSchool of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Chemical Engineering, Ming Chi University of Technology, New Taipei City, TaiwanThis review describes targeting neutrophils as a potential therapeutic strategy for acute respiratory distress syndrome (ARDS) associated with coronavirus disease 2019 (COVID-19), a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Neutrophil counts are significantly elevated in patients with COVID-19 and significantly correlated with disease severity. The neutrophil-to-lymphocyte ratio can serve as a clinical marker for predicting fatal complications related to ARDS in patients with COVID-19. Neutrophil-associated inflammation plays a critical pathogenic role in ARDS. The effector functions of neutrophils, acting as respiratory burst oxidants, granule proteases, and neutrophil extracellular traps, are linked to the pathogenesis of ARDS. Hence, neutrophils can not only be used as pathogenic markers but also as candidate drug targets for COVID-19 associated ARDS.https://www.frontiersin.org/article/10.3389/fphar.2020.572009/fullcoronavirus disease 2019severe acute respiratory syndrome coronavirus 2acute respiratory distress syndromeneutrophilsneutrophil extracellular trap |
| spellingShingle | Chih-Chao Chiang Chih-Chao Chiang Michal Korinek Michal Korinek Michal Korinek Wei-Jen Cheng Wei-Jen Cheng Wei-Jen Cheng Tsong-Long Hwang Tsong-Long Hwang Tsong-Long Hwang Tsong-Long Hwang Tsong-Long Hwang Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease Frontiers in Pharmacology coronavirus disease 2019 severe acute respiratory syndrome coronavirus 2 acute respiratory distress syndrome neutrophils neutrophil extracellular trap |
| title | Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease |
| title_full | Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease |
| title_fullStr | Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease |
| title_full_unstemmed | Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease |
| title_short | Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease |
| title_sort | targeting neutrophils to treat acute respiratory distress syndrome in coronavirus disease |
| topic | coronavirus disease 2019 severe acute respiratory syndrome coronavirus 2 acute respiratory distress syndrome neutrophils neutrophil extracellular trap |
| url | https://www.frontiersin.org/article/10.3389/fphar.2020.572009/full |
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