The SARS-CoV-2 mutation landscape is shaped before replication starts
Abstract Mutation landscapes and signatures have been thoroughly studied in SARS-CoV-2. Here, we analyse those patterns and link their changes to the viral replication tissue in the respiratory tract. Surprisingly, a substantial difference in those patterns is observed in samples from vaccinated pat...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Genética
2023-06-01
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572023000400801&tlng=en |
| _version_ | 1797791471183593472 |
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| author | Diego Masone Maria Soledad Alvarez Luis Mariano Polo |
| author_facet | Diego Masone Maria Soledad Alvarez Luis Mariano Polo |
| author_sort | Diego Masone |
| collection | DOAJ |
| description | Abstract Mutation landscapes and signatures have been thoroughly studied in SARS-CoV-2. Here, we analyse those patterns and link their changes to the viral replication tissue in the respiratory tract. Surprisingly, a substantial difference in those patterns is observed in samples from vaccinated patients. Hence, we propose a model to explain where those mutations could originate during the replication cycle. |
| first_indexed | 2024-03-13T02:19:16Z |
| format | Article |
| id | doaj.art-b3b85bab8a40410599b2e30c5aac5a4a |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-03-13T02:19:16Z |
| publishDate | 2023-06-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-b3b85bab8a40410599b2e30c5aac5a4a2023-06-30T10:55:03ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852023-06-0146210.1590/1678-4685-gmb-2023-0005The SARS-CoV-2 mutation landscape is shaped before replication startsDiego Masonehttps://orcid.org/0000-0001-5770-8614Maria Soledad Alvarezhttps://orcid.org/0000-0001-7062-014XLuis Mariano Polohttps://orcid.org/0000-0001-9257-6127Abstract Mutation landscapes and signatures have been thoroughly studied in SARS-CoV-2. Here, we analyse those patterns and link their changes to the viral replication tissue in the respiratory tract. Surprisingly, a substantial difference in those patterns is observed in samples from vaccinated patients. Hence, we propose a model to explain where those mutations could originate during the replication cycle.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572023000400801&tlng=enSBS spectraviral replication nicheCOVID19 vaccination status |
| spellingShingle | Diego Masone Maria Soledad Alvarez Luis Mariano Polo The SARS-CoV-2 mutation landscape is shaped before replication starts Genetics and Molecular Biology SBS spectra viral replication niche COVID19 vaccination status |
| title | The SARS-CoV-2 mutation landscape is shaped before replication starts |
| title_full | The SARS-CoV-2 mutation landscape is shaped before replication starts |
| title_fullStr | The SARS-CoV-2 mutation landscape is shaped before replication starts |
| title_full_unstemmed | The SARS-CoV-2 mutation landscape is shaped before replication starts |
| title_short | The SARS-CoV-2 mutation landscape is shaped before replication starts |
| title_sort | sars cov 2 mutation landscape is shaped before replication starts |
| topic | SBS spectra viral replication niche COVID19 vaccination status |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572023000400801&tlng=en |
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