The SARS-CoV-2 mutation landscape is shaped before replication starts
Abstract Mutation landscapes and signatures have been thoroughly studied in SARS-CoV-2. Here, we analyse those patterns and link their changes to the viral replication tissue in the respiratory tract. Surprisingly, a substantial difference in those patterns is observed in samples from vaccinated pat...
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Format: | Article |
Language: | English |
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Sociedade Brasileira de Genética
2023-06-01
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Series: | Genetics and Molecular Biology |
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572023000400801&tlng=en |
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author | Diego Masone Maria Soledad Alvarez Luis Mariano Polo |
author_facet | Diego Masone Maria Soledad Alvarez Luis Mariano Polo |
author_sort | Diego Masone |
collection | DOAJ |
description | Abstract Mutation landscapes and signatures have been thoroughly studied in SARS-CoV-2. Here, we analyse those patterns and link their changes to the viral replication tissue in the respiratory tract. Surprisingly, a substantial difference in those patterns is observed in samples from vaccinated patients. Hence, we propose a model to explain where those mutations could originate during the replication cycle. |
first_indexed | 2024-03-13T02:19:16Z |
format | Article |
id | doaj.art-b3b85bab8a40410599b2e30c5aac5a4a |
institution | Directory Open Access Journal |
issn | 1678-4685 |
language | English |
last_indexed | 2024-03-13T02:19:16Z |
publishDate | 2023-06-01 |
publisher | Sociedade Brasileira de Genética |
record_format | Article |
series | Genetics and Molecular Biology |
spelling | doaj.art-b3b85bab8a40410599b2e30c5aac5a4a2023-06-30T10:55:03ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852023-06-0146210.1590/1678-4685-gmb-2023-0005The SARS-CoV-2 mutation landscape is shaped before replication startsDiego Masonehttps://orcid.org/0000-0001-5770-8614Maria Soledad Alvarezhttps://orcid.org/0000-0001-7062-014XLuis Mariano Polohttps://orcid.org/0000-0001-9257-6127Abstract Mutation landscapes and signatures have been thoroughly studied in SARS-CoV-2. Here, we analyse those patterns and link their changes to the viral replication tissue in the respiratory tract. Surprisingly, a substantial difference in those patterns is observed in samples from vaccinated patients. Hence, we propose a model to explain where those mutations could originate during the replication cycle.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572023000400801&tlng=enSBS spectraviral replication nicheCOVID19 vaccination status |
spellingShingle | Diego Masone Maria Soledad Alvarez Luis Mariano Polo The SARS-CoV-2 mutation landscape is shaped before replication starts Genetics and Molecular Biology SBS spectra viral replication niche COVID19 vaccination status |
title | The SARS-CoV-2 mutation landscape is shaped before replication starts |
title_full | The SARS-CoV-2 mutation landscape is shaped before replication starts |
title_fullStr | The SARS-CoV-2 mutation landscape is shaped before replication starts |
title_full_unstemmed | The SARS-CoV-2 mutation landscape is shaped before replication starts |
title_short | The SARS-CoV-2 mutation landscape is shaped before replication starts |
title_sort | sars cov 2 mutation landscape is shaped before replication starts |
topic | SBS spectra viral replication niche COVID19 vaccination status |
url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572023000400801&tlng=en |
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