The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis
Abstract Dietary lipids can affect metabolic health through gut microbiota-mediated mechanisms, but the influence of lipid-microbiota interaction on liver steatosis is largely unknown. We investigate the impact of dietary lipids on human gut microbiota composition and the effects of microbiota-lipid...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-41074-3 |
| _version_ | 1797558606217871360 |
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| author | Marc Schoeler Sandrine Ellero-Simatos Till Birkner Jordi Mayneris-Perxachs Lisa Olsson Harald Brolin Ulrike Loeber Jamie D. Kraft Arnaud Polizzi Marian Martí-Navas Josep Puig Antonio Moschetta Alexandra Montagner Pierre Gourdy Christophe Heymes Hervé Guillou Valentina Tremaroli José Manuel Fernández-Real Sofia K. Forslund Remy Burcelin Robert Caesar |
| author_facet | Marc Schoeler Sandrine Ellero-Simatos Till Birkner Jordi Mayneris-Perxachs Lisa Olsson Harald Brolin Ulrike Loeber Jamie D. Kraft Arnaud Polizzi Marian Martí-Navas Josep Puig Antonio Moschetta Alexandra Montagner Pierre Gourdy Christophe Heymes Hervé Guillou Valentina Tremaroli José Manuel Fernández-Real Sofia K. Forslund Remy Burcelin Robert Caesar |
| author_sort | Marc Schoeler |
| collection | DOAJ |
| description | Abstract Dietary lipids can affect metabolic health through gut microbiota-mediated mechanisms, but the influence of lipid-microbiota interaction on liver steatosis is largely unknown. We investigate the impact of dietary lipids on human gut microbiota composition and the effects of microbiota-lipid interactions on steatosis in male mice. In humans, low intake of saturated fatty acids (SFA) is associated with increased microbial diversity independent of fiber intake. In mice, poorly absorbed dietary long-chain SFA, particularly stearic acid, induce a shift in bile acid profile and improved metabolism and steatosis. These benefits are dependent on the gut microbiota, as they are transmitted by microbial transfer. Diets enriched in polyunsaturated fatty acids are protective against steatosis but have minor influence on the microbiota. In summary, we find that diets enriched in poorly absorbed long-chain SFA modulate gut microbiota profiles independent of fiber intake, and this interaction is relevant to improve metabolism and decrease liver steatosis. |
| first_indexed | 2024-03-10T17:32:52Z |
| format | Article |
| id | doaj.art-b3b8887947dd4c14b3e0120418bffa47 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:32:52Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b3b8887947dd4c14b3e0120418bffa472023-11-20T09:57:43ZengNature PortfolioNature Communications2041-17232023-09-0114111610.1038/s41467-023-41074-3The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosisMarc Schoeler0Sandrine Ellero-Simatos1Till Birkner2Jordi Mayneris-Perxachs3Lisa Olsson4Harald Brolin5Ulrike Loeber6Jamie D. Kraft7Arnaud Polizzi8Marian Martí-Navas9Josep Puig10Antonio Moschetta11Alexandra Montagner12Pierre Gourdy13Christophe Heymes14Hervé Guillou15Valentina Tremaroli16José Manuel Fernández-Real17Sofia K. Forslund18Remy Burcelin19Robert Caesar20The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of GothenburgToxalim (Research Center in Food Toxicology), INRAE, ENVT, INP- PURPAN, UMR 1331, UPS, Université de ToulouseMax Delbrück Center for Molecular Medicine in the Helmholtz AssociationDepartment of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University HospitalThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of GothenburgThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of GothenburgMax Delbrück Center for Molecular Medicine in the Helmholtz AssociationThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of GothenburgToxalim (Research Center in Food Toxicology), INRAE, ENVT, INP- PURPAN, UMR 1331, UPS, Université de ToulouseDepartment of Radiology, Biomedical Research Institute Imaging Research Unit, Diagnostic Imaging Institute, Doctor Josep Trueta University Hospital of GironaDepartment of Radiology, Biomedical Research Institute Imaging Research Unit, Diagnostic Imaging Institute, Doctor Josep Trueta University Hospital of GironaDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”Institut des Maladies Métaboliques et Cardiovasculaires, INSERM UMR 1297, Université Paul Sabatier, Université de ToulouseInstitut des Maladies Métaboliques et Cardiovasculaires, INSERM UMR 1297, Université Paul Sabatier, Université de ToulouseInstitut des Maladies Métaboliques et Cardiovasculaires, INSERM UMR 1297, Université Paul Sabatier, Université de ToulouseToxalim (Research Center in Food Toxicology), INRAE, ENVT, INP- PURPAN, UMR 1331, UPS, Université de ToulouseThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of GothenburgDepartment of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University HospitalMax Delbrück Center for Molecular Medicine in the Helmholtz AssociationInstitut des Maladies Métaboliques et Cardiovasculaires, INSERM UMR 1297, Université Paul Sabatier, Université de ToulouseThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of GothenburgAbstract Dietary lipids can affect metabolic health through gut microbiota-mediated mechanisms, but the influence of lipid-microbiota interaction on liver steatosis is largely unknown. We investigate the impact of dietary lipids on human gut microbiota composition and the effects of microbiota-lipid interactions on steatosis in male mice. In humans, low intake of saturated fatty acids (SFA) is associated with increased microbial diversity independent of fiber intake. In mice, poorly absorbed dietary long-chain SFA, particularly stearic acid, induce a shift in bile acid profile and improved metabolism and steatosis. These benefits are dependent on the gut microbiota, as they are transmitted by microbial transfer. Diets enriched in polyunsaturated fatty acids are protective against steatosis but have minor influence on the microbiota. In summary, we find that diets enriched in poorly absorbed long-chain SFA modulate gut microbiota profiles independent of fiber intake, and this interaction is relevant to improve metabolism and decrease liver steatosis.https://doi.org/10.1038/s41467-023-41074-3 |
| spellingShingle | Marc Schoeler Sandrine Ellero-Simatos Till Birkner Jordi Mayneris-Perxachs Lisa Olsson Harald Brolin Ulrike Loeber Jamie D. Kraft Arnaud Polizzi Marian Martí-Navas Josep Puig Antonio Moschetta Alexandra Montagner Pierre Gourdy Christophe Heymes Hervé Guillou Valentina Tremaroli José Manuel Fernández-Real Sofia K. Forslund Remy Burcelin Robert Caesar The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis Nature Communications |
| title | The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis |
| title_full | The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis |
| title_fullStr | The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis |
| title_full_unstemmed | The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis |
| title_short | The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis |
| title_sort | interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis |
| url | https://doi.org/10.1038/s41467-023-41074-3 |
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