Expiratory airflow at 7–8 years of age in children born extremely low birthweight from 14 years before to 14 years after the introduction of exogenous surfactantResearch in context
Summary: Background: It is unclear if expiratory airflow in survivors born extremely low birth weight (ELBW; 500–999 g) has improved after the introduction of exogenous surfactant into clinical practice in 1991. The primary aim of this study was to describe the changes in airflow at 7–8 years of ag...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
|
| Series: | EClinicalMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537023002924 |
| _version_ | 1797738954014851072 |
|---|---|
| author | Lex W. Doyle S. Ranganathan A.J. Spittle G. Opie R.M. Mainzer Jeanie L.Y. Cheong Jeanie Cheong Peter Anderson Rosemarie Boland Margaret Charlton Noni Davis Lex W. Doyle Julianne Duff Elisha Josev Katherine Lee Rheanna Mainzer Marion McDonald Bronwyn Novella Joy Olsen Gillian Opie Lauren Pigdon Gehan Roberts Alicia Spittle Penelope Stevens Alice Stewart |
| author_facet | Lex W. Doyle S. Ranganathan A.J. Spittle G. Opie R.M. Mainzer Jeanie L.Y. Cheong Jeanie Cheong Peter Anderson Rosemarie Boland Margaret Charlton Noni Davis Lex W. Doyle Julianne Duff Elisha Josev Katherine Lee Rheanna Mainzer Marion McDonald Bronwyn Novella Joy Olsen Gillian Opie Lauren Pigdon Gehan Roberts Alicia Spittle Penelope Stevens Alice Stewart |
| author_sort | Lex W. Doyle |
| collection | DOAJ |
| description | Summary: Background: It is unclear if expiratory airflow in survivors born extremely low birth weight (ELBW; 500–999 g) has improved after the introduction of exogenous surfactant into clinical practice in 1991. The primary aim of this study was to describe the changes in airflow at 7–8 years of age of survivors born ELBW in five discrete cohorts from 14 years before to 14 years after the introduction of exogenous surfactant into clinical practice. Methods: The cohorts comprised consecutive survivors born ELBW in 1977–82 and 1985–87 at the Royal Women's Hospital, Melbourne, and in 1991–92, 1997 and 2005 in the state of Victoria, Australia. Survival rates to 2-years of age for infants born ELBW in the state of Victoria rose from approximately 1-in-4 to 3-in-4 over the time of this study. Expiratory airflow measurements at 7–8 years included the forced expired volume in 1 s (FEV1), converted to z-scores for age, height, sex, and race. Findings: There were 596 ELBW participants with expiratory flow data, 280 (47%) of whom had bronchopulmonary dysplasia (BPD). Overall, there was little change in zFEV1 over the 28-year period (mean change per year; 0.003, 95% CI −0.010, 0.015, P = 0.67). There was, however, evidence of an interaction between BPD and year; zFEV1 in those who had BPD fell over time (mean change per year −0.019, 95% CI −0.037, −0.009, P = 0.035), whereas zFEV1 improved in those who did not have BPD (mean change per year 0.021, 95% CI 0.006, 0.037, P = 0.007). Interpretation: Contrary to recent evidence, expiratory airflow of children born ELBW has not improved with the introduction of surfactant, and may be deteriorating in those who had BPD. Funding: National Health and Medical Research Council (Australia); Victorian Government’s Operational Infrastructure Support Program. |
| first_indexed | 2024-03-12T13:51:17Z |
| format | Article |
| id | doaj.art-b3b9850893e04ab09d137ac58dfa22a9 |
| institution | Directory Open Access Journal |
| issn | 2589-5370 |
| language | English |
| last_indexed | 2024-03-12T13:51:17Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj.art-b3b9850893e04ab09d137ac58dfa22a92023-08-23T04:34:02ZengElsevierEClinicalMedicine2589-53702023-08-0162102115Expiratory airflow at 7–8 years of age in children born extremely low birthweight from 14 years before to 14 years after the introduction of exogenous surfactantResearch in contextLex W. Doyle0S. Ranganathan1A.J. Spittle2G. Opie3R.M. Mainzer4Jeanie L.Y. Cheong5Jeanie CheongPeter AndersonRosemarie BolandMargaret CharltonNoni DavisLex W. DoyleJulianne DuffElisha JosevKatherine LeeRheanna MainzerMarion McDonaldBronwyn NovellaJoy OlsenGillian OpieLauren PigdonGehan RobertsAlicia SpittlePenelope StevensAlice StewartDepartment of Obstetrics and Gynaecology, The Royal Women's Hospital, Melbourne, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Australia; Newborn Services, The Royal Women's Hospital, Melbourne, Australia; Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia; Corresponding author. Department of Obstetrics and Gynaecology, The Royal Women's Hospital, 20 Flemington Rd, Parkville, 3052, Australia.Department of Paediatrics, University of Melbourne, Melbourne, Australia; Department of Respiratory Medicine, Royal Children's Hospital, Melbourne, AustraliaNewborn Services, The Royal Women's Hospital, Melbourne, Australia; Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia; Department of Physiotherapy, University of Melbourne, Melbourne, AustraliaNeonatal Services, Mercy Hospital for Women, Melbourne, AustraliaDepartment of Paediatrics, University of Melbourne, Melbourne, Australia; Clinical Epidemiology and Biostatistics, Murdoch Children's Research Institute, Melbourne, AustraliaDepartment of Obstetrics and Gynaecology, The Royal Women's Hospital, Melbourne, Australia; Newborn Services, The Royal Women's Hospital, Melbourne, Australia; Clinical Sciences, Murdoch Children's Research Institute, Melbourne, AustraliaSummary: Background: It is unclear if expiratory airflow in survivors born extremely low birth weight (ELBW; 500–999 g) has improved after the introduction of exogenous surfactant into clinical practice in 1991. The primary aim of this study was to describe the changes in airflow at 7–8 years of age of survivors born ELBW in five discrete cohorts from 14 years before to 14 years after the introduction of exogenous surfactant into clinical practice. Methods: The cohorts comprised consecutive survivors born ELBW in 1977–82 and 1985–87 at the Royal Women's Hospital, Melbourne, and in 1991–92, 1997 and 2005 in the state of Victoria, Australia. Survival rates to 2-years of age for infants born ELBW in the state of Victoria rose from approximately 1-in-4 to 3-in-4 over the time of this study. Expiratory airflow measurements at 7–8 years included the forced expired volume in 1 s (FEV1), converted to z-scores for age, height, sex, and race. Findings: There were 596 ELBW participants with expiratory flow data, 280 (47%) of whom had bronchopulmonary dysplasia (BPD). Overall, there was little change in zFEV1 over the 28-year period (mean change per year; 0.003, 95% CI −0.010, 0.015, P = 0.67). There was, however, evidence of an interaction between BPD and year; zFEV1 in those who had BPD fell over time (mean change per year −0.019, 95% CI −0.037, −0.009, P = 0.035), whereas zFEV1 improved in those who did not have BPD (mean change per year 0.021, 95% CI 0.006, 0.037, P = 0.007). Interpretation: Contrary to recent evidence, expiratory airflow of children born ELBW has not improved with the introduction of surfactant, and may be deteriorating in those who had BPD. Funding: National Health and Medical Research Council (Australia); Victorian Government’s Operational Infrastructure Support Program.http://www.sciencedirect.com/science/article/pii/S2589537023002924Extremely low birthweightExpiratory airflowBronchopulmonary dysplasiaSurfactant |
| spellingShingle | Lex W. Doyle S. Ranganathan A.J. Spittle G. Opie R.M. Mainzer Jeanie L.Y. Cheong Jeanie Cheong Peter Anderson Rosemarie Boland Margaret Charlton Noni Davis Lex W. Doyle Julianne Duff Elisha Josev Katherine Lee Rheanna Mainzer Marion McDonald Bronwyn Novella Joy Olsen Gillian Opie Lauren Pigdon Gehan Roberts Alicia Spittle Penelope Stevens Alice Stewart Expiratory airflow at 7–8 years of age in children born extremely low birthweight from 14 years before to 14 years after the introduction of exogenous surfactantResearch in context EClinicalMedicine Extremely low birthweight Expiratory airflow Bronchopulmonary dysplasia Surfactant |
| title | Expiratory airflow at 7–8 years of age in children born extremely low birthweight from 14 years before to 14 years after the introduction of exogenous surfactantResearch in context |
| title_full | Expiratory airflow at 7–8 years of age in children born extremely low birthweight from 14 years before to 14 years after the introduction of exogenous surfactantResearch in context |
| title_fullStr | Expiratory airflow at 7–8 years of age in children born extremely low birthweight from 14 years before to 14 years after the introduction of exogenous surfactantResearch in context |
| title_full_unstemmed | Expiratory airflow at 7–8 years of age in children born extremely low birthweight from 14 years before to 14 years after the introduction of exogenous surfactantResearch in context |
| title_short | Expiratory airflow at 7–8 years of age in children born extremely low birthweight from 14 years before to 14 years after the introduction of exogenous surfactantResearch in context |
| title_sort | expiratory airflow at 7 8 years of age in children born extremely low birthweight from 14 years before to 14 years after the introduction of exogenous surfactantresearch in context |
| topic | Extremely low birthweight Expiratory airflow Bronchopulmonary dysplasia Surfactant |
| url | http://www.sciencedirect.com/science/article/pii/S2589537023002924 |
| work_keys_str_mv | AT lexwdoyle expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT sranganathan expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT ajspittle expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT gopie expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT rmmainzer expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT jeanielycheong expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT jeaniecheong expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT peteranderson expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT rosemarieboland expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT margaretcharlton expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT nonidavis expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT lexwdoyle expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT julianneduff expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT elishajosev expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT katherinelee expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT rheannamainzer expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT marionmcdonald expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT bronwynnovella expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT joyolsen expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT gillianopie expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT laurenpigdon expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT gehanroberts expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT aliciaspittle expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT penelopestevens expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext AT alicestewart expiratoryairflowat78yearsofageinchildrenbornextremelylowbirthweightfrom14yearsbeforeto14yearsaftertheintroductionofexogenoussurfactantresearchincontext |