Additively Manufactured Zn‐2Mg Alloy Porous Scaffolds with Customizable Biodegradable Performance and Enhanced Osteogenic Ability
Abstract The combination of bioactive Zn‐2Mg alloy and additively manufactured porous scaffold is expected to achieve customizable biodegradable performance and enhanced bone regeneration. Herein, Zn‐2Mg alloy scaffolds with different porosities, including 40% (G‐40‐2), 60% (G‐60‐2), and 80% (G‐80‐2...
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202307329 |
| _version_ | 1797329390187577344 |
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| author | Xuan Wang Aobo Liu Zhenbao Zhang Dazhong Hao Yijie Liang Jiabao Dai Xiang Jin Huanze Deng Yantao Zhao Peng Wen Yanfeng Li |
| author_facet | Xuan Wang Aobo Liu Zhenbao Zhang Dazhong Hao Yijie Liang Jiabao Dai Xiang Jin Huanze Deng Yantao Zhao Peng Wen Yanfeng Li |
| author_sort | Xuan Wang |
| collection | DOAJ |
| description | Abstract The combination of bioactive Zn‐2Mg alloy and additively manufactured porous scaffold is expected to achieve customizable biodegradable performance and enhanced bone regeneration. Herein, Zn‐2Mg alloy scaffolds with different porosities, including 40% (G‐40‐2), 60% (G‐60‐2), and 80% (G‐80‐2), and different unit sizes, including 1.5 mm (G‐60‐1.5), 2 mm (G‐60‐2), and 2.5 mm (G‐60‐2.5), are manufactured by a triply periodic minimal surface design and a reliable laser powder bed fusion process. With the same unit size, compressive strength (CS) and elastic modulus (EM) of scaffolds substantially decrease with increasing porosities. With the same porosity, CS and EM just slightly decrease with increasing unit sizes. The weight loss after degradation increases with increasing porosities and decreasing unit sizes. In vivo tests indicate that Zn‐2Mg alloy scaffolds exhibit satisfactory biocompatibility and osteogenic ability. The osteogenic ability of scaffolds is mainly determined by their physical and chemical characteristics. Scaffolds with lower porosities and smaller unit sizes show better osteogenesis due to their suitable pore size and larger surface area. The results indicate that the biodegradable performance of scaffolds can be accurately regulated on a large scale by structure design and the additively manufactured Zn‐2Mg alloy scaffolds have improved osteogenic ability for treating bone defects. |
| first_indexed | 2024-03-08T07:05:06Z |
| format | Article |
| id | doaj.art-b3ba9f5e2c9347c6bce377631df678b8 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-08T07:05:06Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-b3ba9f5e2c9347c6bce377631df678b82024-02-03T05:02:44ZengWileyAdvanced Science2198-38442024-02-01115n/an/a10.1002/advs.202307329Additively Manufactured Zn‐2Mg Alloy Porous Scaffolds with Customizable Biodegradable Performance and Enhanced Osteogenic AbilityXuan Wang0Aobo Liu1Zhenbao Zhang2Dazhong Hao3Yijie Liang4Jiabao Dai5Xiang Jin6Huanze Deng7Yantao Zhao8Peng Wen9Yanfeng Li10Postgraduate Training Base Jinzhou Medical University and The Fourth Medical Centre Chinese PLA General Hospital Beijing 100048 ChinaState Key Laboratory of Tribology in Advanced Equipment Beijing 100084 ChinaDepartment of Stomatology the Fourth Medical Centre Chinese PLA General Hospital Beijing 100048 ChinaState Key Laboratory of Tribology in Advanced Equipment Beijing 100084 ChinaDepartment of Stomatology the Fourth Medical Centre Chinese PLA General Hospital Beijing 100048 ChinaState Key Laboratory of Tribology in Advanced Equipment Beijing 100084 ChinaDepartment of Stomatology the Fourth Medical Centre Chinese PLA General Hospital Beijing 100048 ChinaDepartment of Stomatology the Fourth Medical Centre Chinese PLA General Hospital Beijing 100048 ChinaDepartment of Stomatology the Fourth Medical Centre Chinese PLA General Hospital Beijing 100048 ChinaState Key Laboratory of Tribology in Advanced Equipment Beijing 100084 ChinaPostgraduate Training Base Jinzhou Medical University and The Fourth Medical Centre Chinese PLA General Hospital Beijing 100048 ChinaAbstract The combination of bioactive Zn‐2Mg alloy and additively manufactured porous scaffold is expected to achieve customizable biodegradable performance and enhanced bone regeneration. Herein, Zn‐2Mg alloy scaffolds with different porosities, including 40% (G‐40‐2), 60% (G‐60‐2), and 80% (G‐80‐2), and different unit sizes, including 1.5 mm (G‐60‐1.5), 2 mm (G‐60‐2), and 2.5 mm (G‐60‐2.5), are manufactured by a triply periodic minimal surface design and a reliable laser powder bed fusion process. With the same unit size, compressive strength (CS) and elastic modulus (EM) of scaffolds substantially decrease with increasing porosities. With the same porosity, CS and EM just slightly decrease with increasing unit sizes. The weight loss after degradation increases with increasing porosities and decreasing unit sizes. In vivo tests indicate that Zn‐2Mg alloy scaffolds exhibit satisfactory biocompatibility and osteogenic ability. The osteogenic ability of scaffolds is mainly determined by their physical and chemical characteristics. Scaffolds with lower porosities and smaller unit sizes show better osteogenesis due to their suitable pore size and larger surface area. The results indicate that the biodegradable performance of scaffolds can be accurately regulated on a large scale by structure design and the additively manufactured Zn‐2Mg alloy scaffolds have improved osteogenic ability for treating bone defects.https://doi.org/10.1002/advs.202307329additive manufacturingbiodegradable performanceosteogenic abilitystructure designZn‐Mg alloy |
| spellingShingle | Xuan Wang Aobo Liu Zhenbao Zhang Dazhong Hao Yijie Liang Jiabao Dai Xiang Jin Huanze Deng Yantao Zhao Peng Wen Yanfeng Li Additively Manufactured Zn‐2Mg Alloy Porous Scaffolds with Customizable Biodegradable Performance and Enhanced Osteogenic Ability Advanced Science additive manufacturing biodegradable performance osteogenic ability structure design Zn‐Mg alloy |
| title | Additively Manufactured Zn‐2Mg Alloy Porous Scaffolds with Customizable Biodegradable Performance and Enhanced Osteogenic Ability |
| title_full | Additively Manufactured Zn‐2Mg Alloy Porous Scaffolds with Customizable Biodegradable Performance and Enhanced Osteogenic Ability |
| title_fullStr | Additively Manufactured Zn‐2Mg Alloy Porous Scaffolds with Customizable Biodegradable Performance and Enhanced Osteogenic Ability |
| title_full_unstemmed | Additively Manufactured Zn‐2Mg Alloy Porous Scaffolds with Customizable Biodegradable Performance and Enhanced Osteogenic Ability |
| title_short | Additively Manufactured Zn‐2Mg Alloy Porous Scaffolds with Customizable Biodegradable Performance and Enhanced Osteogenic Ability |
| title_sort | additively manufactured zn 2mg alloy porous scaffolds with customizable biodegradable performance and enhanced osteogenic ability |
| topic | additive manufacturing biodegradable performance osteogenic ability structure design Zn‐Mg alloy |
| url | https://doi.org/10.1002/advs.202307329 |
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