RSK1 vs. RSK2 Inhibitory Activity of the Marine β-Carboline Alkaloid Manzamine A: A Biochemical, Cervical Cancer Protein Expression, and Computational Study

RSK1 vs. RSK2 Inhibitory Activity of the Marine β-Carboline Alkaloid Manzamine A: A Biochemical, Cervical Cancer Protein Expression, and Computational Study

Manzamines are complex polycyclic marine-derived β-carboline alkaloids with reported anticancer, immunostimulatory, anti-inflammatory, antibacterial, antiviral, antimalarial, neuritogenic, hyperlipidemia, and atherosclerosis suppression bioactivities, putatively associated with inhibition of glycoge...

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Bibliographic Details
Main Authors: Alejandro M. S. Mayer, Mary L. Hall, Joseph Lach, Jonathan Clifford, Kevin Chandrasena, Caitlin Canton, Maria Kontoyianni, Yeun-Mun Choo, Dev Karan, Mark T. Hamann
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Marine Drugs
Subjects:
MZA
Manzamine A
CTKD
C-terminal kinase domain
ras-ERK1/2 (extracellular-signal-regulated kinase 1/2) pathway
RSK1
Online Access:https://www.mdpi.com/1660-3397/19/9/506

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