Status of multidrug resistant tuberculosis (MDR-TB) among the Sahariya tribe of North Central India
Summary: Background: The incidence/prevalence of tuberculosis (TB) is reported to be high in the Sahariya tribe of North Central India. The outbreaks of different drug-resistant isolates of Mycobacterium tuberculosis emphasized the need for continuous monitoring of resistance to anti-tuberculosis d...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-05-01
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| Series: | Journal of Infection and Public Health |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034115001914 |
| _version_ | 1817988365138526208 |
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| author | Ravi Prakash Dilip Kumar Vinod K. Gupta Sanjay Jain Devendra S. Chauhan Pramod K. Tiwari Vishwa M. Katoch |
| author_facet | Ravi Prakash Dilip Kumar Vinod K. Gupta Sanjay Jain Devendra S. Chauhan Pramod K. Tiwari Vishwa M. Katoch |
| author_sort | Ravi Prakash |
| collection | DOAJ |
| description | Summary: Background: The incidence/prevalence of tuberculosis (TB) is reported to be high in the Sahariya tribe of North Central India. The outbreaks of different drug-resistant isolates of Mycobacterium tuberculosis emphasized the need for continuous monitoring of resistance to anti-tuberculosis drugs. This study aimed to assess the profile of multidrug resistant TB among the Sahariya tribe and their non-tribal neighbors for first line drugs through field-based investigations. Methodology: A total of 274 sputum positive pulmonary TB individuals were enrolled and studied for their drug susceptibility profile by the proportion method. Results: A total of 21 cases from Sahariya and 6 from non-tribes were identified with MDR-TB. Thus Sahariya tribe showed a 1.95-fold increased risk of developing drug resistance than non-tribes. Significant differences were observed for developing drug sensitivity between Sahariya males and females when analyzed for resistance developed to any drug and overall drug resistance vs. sensitive isolates, respectively. A 4.46-fold risk was found for MDR-TB among the smokers of Sahariya tribe, whereas, the non-tribes did not show any significant association. Conclusion: The drug susceptibility profile developed in the present study indicates that drug-resistant tuberculosis is emerging as a serious public health concern in Sahariya tribe. Urgent and effective control measures and better management policies are needed for the prevention of MDR-TB in the tribe. Keywords: Sahariya tribe, Mycobacterium tuberculosis, MDR-TB |
| first_indexed | 2024-04-14T00:33:20Z |
| format | Article |
| id | doaj.art-b3bd2ea3b4a24fc7b603d92c4b4bd044 |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-04-14T00:33:20Z |
| publishDate | 2016-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-b3bd2ea3b4a24fc7b603d92c4b4bd0442022-12-22T02:22:28ZengElsevierJournal of Infection and Public Health1876-03412016-05-0193289297Status of multidrug resistant tuberculosis (MDR-TB) among the Sahariya tribe of North Central IndiaRavi Prakash0Dilip Kumar1Vinod K. Gupta2Sanjay Jain3Devendra S. Chauhan4Pramod K. Tiwari5Vishwa M. Katoch6Centre for Genomics, Jiwaji University, Gwalior 474 011, India; School of Studies in Zoology, Jiwaji University, Gwalior 474 011, India; Department of Microbiology and Molecular Biology, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra 282 004, IndiaDepartment of Microbiology and Molecular Biology, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra 282 004, IndiaDistrict TB Health Society, Gwalior, IndiaRevised National Tuberculosis Control Programe, District Hospital, Sheopur, IndiaDepartment of Microbiology and Molecular Biology, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra 282 004, IndiaCentre for Genomics, Jiwaji University, Gwalior 474 011, India; School of Studies in Zoology, Jiwaji University, Gwalior 474 011, India; Corresponding author at: Centre for Genomics, Jiwaji University, Gwalior 474 011, India. Tel.: +91 751 2442772/2442865.Department of Health Research, Ministry of Health & Family Welfare, Government of India, New Delhi, India; Indian Council of Medical Research, New Delhi 110 029, India; Corresponding author at: Department of Health Research, Ministry of Health & Family Welfare, Government of India, New Delhi, India.Summary: Background: The incidence/prevalence of tuberculosis (TB) is reported to be high in the Sahariya tribe of North Central India. The outbreaks of different drug-resistant isolates of Mycobacterium tuberculosis emphasized the need for continuous monitoring of resistance to anti-tuberculosis drugs. This study aimed to assess the profile of multidrug resistant TB among the Sahariya tribe and their non-tribal neighbors for first line drugs through field-based investigations. Methodology: A total of 274 sputum positive pulmonary TB individuals were enrolled and studied for their drug susceptibility profile by the proportion method. Results: A total of 21 cases from Sahariya and 6 from non-tribes were identified with MDR-TB. Thus Sahariya tribe showed a 1.95-fold increased risk of developing drug resistance than non-tribes. Significant differences were observed for developing drug sensitivity between Sahariya males and females when analyzed for resistance developed to any drug and overall drug resistance vs. sensitive isolates, respectively. A 4.46-fold risk was found for MDR-TB among the smokers of Sahariya tribe, whereas, the non-tribes did not show any significant association. Conclusion: The drug susceptibility profile developed in the present study indicates that drug-resistant tuberculosis is emerging as a serious public health concern in Sahariya tribe. Urgent and effective control measures and better management policies are needed for the prevention of MDR-TB in the tribe. Keywords: Sahariya tribe, Mycobacterium tuberculosis, MDR-TBhttp://www.sciencedirect.com/science/article/pii/S1876034115001914 |
| spellingShingle | Ravi Prakash Dilip Kumar Vinod K. Gupta Sanjay Jain Devendra S. Chauhan Pramod K. Tiwari Vishwa M. Katoch Status of multidrug resistant tuberculosis (MDR-TB) among the Sahariya tribe of North Central India Journal of Infection and Public Health |
| title | Status of multidrug resistant tuberculosis (MDR-TB) among the Sahariya tribe of North Central India |
| title_full | Status of multidrug resistant tuberculosis (MDR-TB) among the Sahariya tribe of North Central India |
| title_fullStr | Status of multidrug resistant tuberculosis (MDR-TB) among the Sahariya tribe of North Central India |
| title_full_unstemmed | Status of multidrug resistant tuberculosis (MDR-TB) among the Sahariya tribe of North Central India |
| title_short | Status of multidrug resistant tuberculosis (MDR-TB) among the Sahariya tribe of North Central India |
| title_sort | status of multidrug resistant tuberculosis mdr tb among the sahariya tribe of north central india |
| url | http://www.sciencedirect.com/science/article/pii/S1876034115001914 |
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