A Rare Case of Latent Tuberculosis Reactivation Secondary to a COVID-19 Infection
Coronavirus disease 2019 (COVID-19) and tuberculosis (TB) are currently the two leading causes of death among infectious diseases. As we progress towards a “new normal”, more information is required regarding post-COVID-19 syndromes. We present a case of latent tuberculosis reactivation 3 months aft...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Infectious Disease Reports |
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| Online Access: | https://www.mdpi.com/2036-7449/14/3/48 |
| _version_ | 1797486789347246080 |
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| author | Ana-Alicia Leonso Kyle Brown Raquel Prol Saumya Rawat Arjun Khunger Romina Bromberg |
| author_facet | Ana-Alicia Leonso Kyle Brown Raquel Prol Saumya Rawat Arjun Khunger Romina Bromberg |
| author_sort | Ana-Alicia Leonso |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) and tuberculosis (TB) are currently the two leading causes of death among infectious diseases. As we progress towards a “new normal”, more information is required regarding post-COVID-19 syndromes. We present a case of latent tuberculosis reactivation 3 months after a successful inpatient treatment of COVID-19. A 74-year-old female from the Philippines presented with a new left mid-lung infiltrate with worsening shortness of breath and lethargy for one week prior to admission. The clinical course of the patient deteriorated despite broad-spectrum antibiotics, diuretics, and high-dose steroid therapy requiring intubation and mechanical ventilation. Her sputum culture yielded the microbiological diagnosis of TB. Anti-tubercular medications were started and the patient had a favorable clinical outcome. Our case demonstrates that immunosuppression secondary to COVID-19 and its treatments may promote the development of an active TB infection from a latent infection. It is important to be aware of this potential increase in risk during and after a COVID-19 treatment. This is especially important in high-risk populations to ensure an early diagnosis and prompt management as well as to reduce transmission. |
| first_indexed | 2024-03-09T23:38:16Z |
| format | Article |
| id | doaj.art-b3be1d4c35164cb7ba203fa4e513c4ef |
| institution | Directory Open Access Journal |
| issn | 2036-7449 |
| language | English |
| last_indexed | 2024-03-09T23:38:16Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Infectious Disease Reports |
| spelling | doaj.art-b3be1d4c35164cb7ba203fa4e513c4ef2023-11-23T16:56:57ZengMDPI AGInfectious Disease Reports2036-74492022-06-0114344645210.3390/idr14030048A Rare Case of Latent Tuberculosis Reactivation Secondary to a COVID-19 InfectionAna-Alicia Leonso0Kyle Brown1Raquel Prol2Saumya Rawat3Arjun Khunger4Romina Bromberg5Department of Graduate Medical Education, Memorial Hospital West, Pembroke Pines, FL 33028, USADepartment of Pharmacy, Memorial Hospital West, Pembroke Pines, FL 33028, USADepartment of Graduate Medical Education, Memorial Hospital West, Pembroke Pines, FL 33028, USADepartment of Graduate Medical Education, Memorial Hospital West, Pembroke Pines, FL 33028, USADepartment of Graduate Medical Education, Memorial Hospital West, Pembroke Pines, FL 33028, USADepartment of Infectious Diseases, Memorial Hospital West, Pembroke Pines, FL 33028, USACoronavirus disease 2019 (COVID-19) and tuberculosis (TB) are currently the two leading causes of death among infectious diseases. As we progress towards a “new normal”, more information is required regarding post-COVID-19 syndromes. We present a case of latent tuberculosis reactivation 3 months after a successful inpatient treatment of COVID-19. A 74-year-old female from the Philippines presented with a new left mid-lung infiltrate with worsening shortness of breath and lethargy for one week prior to admission. The clinical course of the patient deteriorated despite broad-spectrum antibiotics, diuretics, and high-dose steroid therapy requiring intubation and mechanical ventilation. Her sputum culture yielded the microbiological diagnosis of TB. Anti-tubercular medications were started and the patient had a favorable clinical outcome. Our case demonstrates that immunosuppression secondary to COVID-19 and its treatments may promote the development of an active TB infection from a latent infection. It is important to be aware of this potential increase in risk during and after a COVID-19 treatment. This is especially important in high-risk populations to ensure an early diagnosis and prompt management as well as to reduce transmission.https://www.mdpi.com/2036-7449/14/3/48COVID-19latent tuberculosis<i>Mycobacterium tuberculosis</i>SARS-CoV-2 |
| spellingShingle | Ana-Alicia Leonso Kyle Brown Raquel Prol Saumya Rawat Arjun Khunger Romina Bromberg A Rare Case of Latent Tuberculosis Reactivation Secondary to a COVID-19 Infection Infectious Disease Reports COVID-19 latent tuberculosis <i>Mycobacterium tuberculosis</i> SARS-CoV-2 |
| title | A Rare Case of Latent Tuberculosis Reactivation Secondary to a COVID-19 Infection |
| title_full | A Rare Case of Latent Tuberculosis Reactivation Secondary to a COVID-19 Infection |
| title_fullStr | A Rare Case of Latent Tuberculosis Reactivation Secondary to a COVID-19 Infection |
| title_full_unstemmed | A Rare Case of Latent Tuberculosis Reactivation Secondary to a COVID-19 Infection |
| title_short | A Rare Case of Latent Tuberculosis Reactivation Secondary to a COVID-19 Infection |
| title_sort | rare case of latent tuberculosis reactivation secondary to a covid 19 infection |
| topic | COVID-19 latent tuberculosis <i>Mycobacterium tuberculosis</i> SARS-CoV-2 |
| url | https://www.mdpi.com/2036-7449/14/3/48 |
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