Strategies for efficient production of recombinant proteins in Escherichia coli: alleviating the host burden and enhancing protein activity

Strategies for efficient production of recombinant proteins in Escherichia coli: alleviating the host burden and enhancing protein activity

Abstract Escherichia coli, one of the most efficient expression hosts for recombinant proteins (RPs), is widely used in chemical, medical, food and other industries. However, conventional expression strains are unable to effectively express proteins with complex structures or toxicity. The key to so...

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Bibliographic Details
Main Authors: Zi-Xu Zhang, Fang-Tong Nong, Yu-Zhou Wang, Chun-Xiao Yan, Yang Gu, Ping Song, Xiao-Man Sun
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Microbial Cell Factories
Subjects:
Escherichia coli
Recombinant protein
Host burden
Post-translational modification
Inclusion bodies
Online Access:https://doi.org/10.1186/s12934-022-01917-y

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