Can erythema multiforme be an immune sequela of IgM nephropathy? A case report
Abstract A 13-year-old Chinese girl attended to our Pediatric Dermatology Unit for the appearance of itchy targetoid lesions on the trunk, face and upper limbs. A skin biopsy showed histological findings typical of erythema multiforme minor. A month earlier she was admitted for the onset of a nephro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | Italian Journal of Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13052-022-01373-9 |
| _version_ | 1811249892164632576 |
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| author | Francesco Messina Laura Fagotto Francesca Caroppo Roberto Salmaso Anna Belloni Fortina |
| author_facet | Francesco Messina Laura Fagotto Francesca Caroppo Roberto Salmaso Anna Belloni Fortina |
| author_sort | Francesco Messina |
| collection | DOAJ |
| description | Abstract A 13-year-old Chinese girl attended to our Pediatric Dermatology Unit for the appearance of itchy targetoid lesions on the trunk, face and upper limbs. A skin biopsy showed histological findings typical of erythema multiforme minor. A month earlier she was admitted for the onset of a nephrotic syndrome and the renal biopsy showed an IgM nephropathy with a diffuse mesangial cell proliferation. There was no medical history of recent infections, fever, muscle or joint pain, drugs intake related to erythema multiforme and viral serology were negative. The role of antibodies in erythema multiforme could be more relevant than suspected and the severity of erythema multiforme was reported to be proportional to the antibody-mediated complement-dependent cytotoxicity, supporting the potential pathogenetic role for humoral immunity in this subtype of erythema multiforme. We reported the first association of erythema multiforme and IgM nephropathy in a pediatric patient providing an additional hint that an antibody-mediated process, rather than T-cell cytotoxicity, might represent the main pathogenetic mechanism in certain subtypes of erythema multiforme. |
| first_indexed | 2024-04-12T15:54:22Z |
| format | Article |
| id | doaj.art-b3bf51759b024a64bb7db541052947bd |
| institution | Directory Open Access Journal |
| issn | 1824-7288 |
| language | English |
| last_indexed | 2024-04-12T15:54:22Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj.art-b3bf51759b024a64bb7db541052947bd2022-12-22T03:26:25ZengBMCItalian Journal of Pediatrics1824-72882022-10-014811510.1186/s13052-022-01373-9Can erythema multiforme be an immune sequela of IgM nephropathy? A case reportFrancesco Messina0Laura Fagotto1Francesca Caroppo2Roberto Salmaso3Anna Belloni Fortina4Pediatric Dermatology Unit, Department of Medicine DIMED, University of PadovaPediatric Dermatology Unit, Department of Medicine DIMED, University of PadovaPediatric Dermatology Unit, Department of Medicine DIMED, University of PadovaSurgical Pathology and Cytopathology Unit, Department of Medicine DIMED, University of PadovaPediatric Dermatology Unit, Department of Medicine DIMED, University of PadovaAbstract A 13-year-old Chinese girl attended to our Pediatric Dermatology Unit for the appearance of itchy targetoid lesions on the trunk, face and upper limbs. A skin biopsy showed histological findings typical of erythema multiforme minor. A month earlier she was admitted for the onset of a nephrotic syndrome and the renal biopsy showed an IgM nephropathy with a diffuse mesangial cell proliferation. There was no medical history of recent infections, fever, muscle or joint pain, drugs intake related to erythema multiforme and viral serology were negative. The role of antibodies in erythema multiforme could be more relevant than suspected and the severity of erythema multiforme was reported to be proportional to the antibody-mediated complement-dependent cytotoxicity, supporting the potential pathogenetic role for humoral immunity in this subtype of erythema multiforme. We reported the first association of erythema multiforme and IgM nephropathy in a pediatric patient providing an additional hint that an antibody-mediated process, rather than T-cell cytotoxicity, might represent the main pathogenetic mechanism in certain subtypes of erythema multiforme.https://doi.org/10.1186/s13052-022-01373-9Pediatric erythema multiformeIgM nephropathyErythema multiforme |
| spellingShingle | Francesco Messina Laura Fagotto Francesca Caroppo Roberto Salmaso Anna Belloni Fortina Can erythema multiforme be an immune sequela of IgM nephropathy? A case report Italian Journal of Pediatrics Pediatric erythema multiforme IgM nephropathy Erythema multiforme |
| title | Can erythema multiforme be an immune sequela of IgM nephropathy? A case report |
| title_full | Can erythema multiforme be an immune sequela of IgM nephropathy? A case report |
| title_fullStr | Can erythema multiforme be an immune sequela of IgM nephropathy? A case report |
| title_full_unstemmed | Can erythema multiforme be an immune sequela of IgM nephropathy? A case report |
| title_short | Can erythema multiforme be an immune sequela of IgM nephropathy? A case report |
| title_sort | can erythema multiforme be an immune sequela of igm nephropathy a case report |
| topic | Pediatric erythema multiforme IgM nephropathy Erythema multiforme |
| url | https://doi.org/10.1186/s13052-022-01373-9 |
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