Co-existence of acute myeloid leukemia with multilineage dysplasia and Epstein-Barr virus-associated T-cell lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report

<p>Abstract</p> <p>Rheumatoid arthritis (RA) is an autoimmune disease mediated by inflammatory processes mainly at the joints. Recently, awareness of Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder (T-LPD) has been heightened for its association with methotr...

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Main Authors: Suzuki Katsuya, Itoyama Shinji, Tamaru Jun-ichi, Toyozumi Yasuo, Nemoto Tomoe, Sekiguchi Yasunobu, Watanabe Reiko, Hanzawa Kyoko, Tokuhira Michihide, Kameda Hideto, Mori Shigehisa, Kizaki Masahiro
Format: Article
Language:English
Published: BMC 2009-06-01
Series:Journal of Hematology & Oncology
Online Access:http://www.jhoonline.org/content/2/1/27
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Summary:<p>Abstract</p> <p>Rheumatoid arthritis (RA) is an autoimmune disease mediated by inflammatory processes mainly at the joints. Recently, awareness of Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder (T-LPD) has been heightened for its association with methotraxate usage in RA patients. In the contrary, acute myeloid leukemia with multilineage dysplasia (AML-MLD) has never been documented to be present concomitantly with the above two conditions. In this report we present a case of an autopsy-proven co-existence of AML-MLD and EBV-associated T-LPD in a patient with RA.</p>
ISSN:1756-8722