New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents
Carbonic anhydrase IX (CAIX) is a tumor-specific and hypoxia-induced biomarker for the molecular imaging of solid malignancies. The nuclear- and optical-imaging of CAIX-expressing tumors have received great attention due to their potential for clinical applications. Nuclear imaging is a powerful too...
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Format: | Article |
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MDPI AG
2022-05-01
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Series: | International Journal of Molecular Sciences |
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Online Access: | https://www.mdpi.com/1422-0067/23/11/6125 |
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author | Kuo-Ting Chen Yann Seimbille |
author_facet | Kuo-Ting Chen Yann Seimbille |
author_sort | Kuo-Ting Chen |
collection | DOAJ |
description | Carbonic anhydrase IX (CAIX) is a tumor-specific and hypoxia-induced biomarker for the molecular imaging of solid malignancies. The nuclear- and optical-imaging of CAIX-expressing tumors have received great attention due to their potential for clinical applications. Nuclear imaging is a powerful tool for the non-invasive diagnosis of primary and metastatic CAIX-positive tumors and for the assessment of responses to antineoplastic treatment. Intraoperative optical fluorescence imaging provides improved visualization for surgeons to increase the discrimination of tumor lesions, allowing for safer surgical treatment. Over the past decades, many CAIX-targeted molecular imaging probes, based on monoclonal antibodies, antibody fragments, peptides, and small molecules, have been reported. In this review, we outline the recent development of CAIX-targeted probes for single-photon emission computerized tomography (SPECT), positron emission tomography (PET), and near-infrared fluorescence imaging (NIRF), and we discuss issues yet to be addressed. |
first_indexed | 2024-03-10T01:15:29Z |
format | Article |
id | doaj.art-b3c0c707f1ff4bff85eba31d81479475 |
institution | Directory Open Access Journal |
issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-10T01:15:29Z |
publishDate | 2022-05-01 |
publisher | MDPI AG |
record_format | Article |
series | International Journal of Molecular Sciences |
spelling | doaj.art-b3c0c707f1ff4bff85eba31d814794752023-11-23T14:10:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-012311612510.3390/ijms23116125New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging AgentsKuo-Ting Chen0Yann Seimbille1Department of Chemistry, National Dong Hwa University, Hualien 974301, TaiwanDepartment of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Wytemaweg 80, 3015 CN Rotterdam, The NetherlandsCarbonic anhydrase IX (CAIX) is a tumor-specific and hypoxia-induced biomarker for the molecular imaging of solid malignancies. The nuclear- and optical-imaging of CAIX-expressing tumors have received great attention due to their potential for clinical applications. Nuclear imaging is a powerful tool for the non-invasive diagnosis of primary and metastatic CAIX-positive tumors and for the assessment of responses to antineoplastic treatment. Intraoperative optical fluorescence imaging provides improved visualization for surgeons to increase the discrimination of tumor lesions, allowing for safer surgical treatment. Over the past decades, many CAIX-targeted molecular imaging probes, based on monoclonal antibodies, antibody fragments, peptides, and small molecules, have been reported. In this review, we outline the recent development of CAIX-targeted probes for single-photon emission computerized tomography (SPECT), positron emission tomography (PET), and near-infrared fluorescence imaging (NIRF), and we discuss issues yet to be addressed.https://www.mdpi.com/1422-0067/23/11/6125carbonic anhydrase IXcancerimaging agentsPETSPECTfluorescence imaging |
spellingShingle | Kuo-Ting Chen Yann Seimbille New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents International Journal of Molecular Sciences carbonic anhydrase IX cancer imaging agents PET SPECT fluorescence imaging |
title | New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents |
title_full | New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents |
title_fullStr | New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents |
title_full_unstemmed | New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents |
title_short | New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents |
title_sort | new developments in carbonic anhydrase ix targeted fluorescence and nuclear imaging agents |
topic | carbonic anhydrase IX cancer imaging agents PET SPECT fluorescence imaging |
url | https://www.mdpi.com/1422-0067/23/11/6125 |
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