NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types
The Never in Mitosis Gene A (NIMA)–related kinases (NEKs) are a group of serine/threonine kinases that are involved in a wide array of cellular processes including cell cycle regulation, DNA damage repair response (DDR), apoptosis, and microtubule organization. Recent studies have identified the inv...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/7/2067 |
| _version_ | 1797608265967730688 |
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| author | Khoa Nguyen Julia Boehling Minh N. Tran Thomas Cheng Andrew Rivera Bridgette M. Collins-Burow Sean B. Lee David H. Drewry Matthew E. Burow |
| author_facet | Khoa Nguyen Julia Boehling Minh N. Tran Thomas Cheng Andrew Rivera Bridgette M. Collins-Burow Sean B. Lee David H. Drewry Matthew E. Burow |
| author_sort | Khoa Nguyen |
| collection | DOAJ |
| description | The Never in Mitosis Gene A (NIMA)–related kinases (NEKs) are a group of serine/threonine kinases that are involved in a wide array of cellular processes including cell cycle regulation, DNA damage repair response (DDR), apoptosis, and microtubule organization. Recent studies have identified the involvement of NEK family members in various diseases such as autoimmune disorders, malignancies, and developmental defects. Despite the existing literature exemplifying the importance of the NEK family of kinases, this family of protein kinases remains understudied. This report seeks to provide a foundation for investigating the role of different NEKs in malignancies. We do this by evaluating the 11 NEK family kinase gene expression associations with patients’ overall survival (OS) from various cancers using the Kaplan–Meier Online Tool (KMPlotter) to correlate the relationship between mRNA expression of NEK1-11 in various cancers and patient survival. Furthermore, we use the Catalog of Somatic Mutations in Cancer (COSMIC) database to identify NEK family mutations in cancers of different tissues. Overall, the data suggest that the NEK family has varying associations with patient survival in different cancers with tumor-suppressive and tumor-promoting effects being tissue-dependent. |
| first_indexed | 2024-03-11T05:41:12Z |
| format | Article |
| id | doaj.art-b3c4344fcf11475abdcd3c3faa40b68e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T05:41:12Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b3c4344fcf11475abdcd3c3faa40b68e2023-11-17T16:25:42ZengMDPI AGCancers2072-66942023-03-01157206710.3390/cancers15072067NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer TypesKhoa Nguyen0Julia Boehling1Minh N. Tran2Thomas Cheng3Andrew Rivera4Bridgette M. Collins-Burow5Sean B. Lee6David H. Drewry7Matthew E. Burow8Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USADepartment of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USADepartment of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USADepartment of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USADepartment of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USADepartment of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USADepartment of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USAUNC Lineberger Comprehensive Cancer Center, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USAThe Never in Mitosis Gene A (NIMA)–related kinases (NEKs) are a group of serine/threonine kinases that are involved in a wide array of cellular processes including cell cycle regulation, DNA damage repair response (DDR), apoptosis, and microtubule organization. Recent studies have identified the involvement of NEK family members in various diseases such as autoimmune disorders, malignancies, and developmental defects. Despite the existing literature exemplifying the importance of the NEK family of kinases, this family of protein kinases remains understudied. This report seeks to provide a foundation for investigating the role of different NEKs in malignancies. We do this by evaluating the 11 NEK family kinase gene expression associations with patients’ overall survival (OS) from various cancers using the Kaplan–Meier Online Tool (KMPlotter) to correlate the relationship between mRNA expression of NEK1-11 in various cancers and patient survival. Furthermore, we use the Catalog of Somatic Mutations in Cancer (COSMIC) database to identify NEK family mutations in cancers of different tissues. Overall, the data suggest that the NEK family has varying associations with patient survival in different cancers with tumor-suppressive and tumor-promoting effects being tissue-dependent.https://www.mdpi.com/2072-6694/15/7/2067NEK familykinasecancer signalingKMPlotcosmic mutationbioinformatics |
| spellingShingle | Khoa Nguyen Julia Boehling Minh N. Tran Thomas Cheng Andrew Rivera Bridgette M. Collins-Burow Sean B. Lee David H. Drewry Matthew E. Burow NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types Cancers NEK family kinase cancer signaling KMPlot cosmic mutation bioinformatics |
| title | NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types |
| title_full | NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types |
| title_fullStr | NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types |
| title_full_unstemmed | NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types |
| title_short | NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types |
| title_sort | nek family review and correlations with patient survival outcomes in various cancer types |
| topic | NEK family kinase cancer signaling KMPlot cosmic mutation bioinformatics |
| url | https://www.mdpi.com/2072-6694/15/7/2067 |
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