Protonophore treatment augments energy expenditure in mice housed at thermoneutrality

Protonophore treatment augments energy expenditure in mice housed at thermoneutrality

BackgroundSub-thermoneutral housing increases facultative thermogenesis in mice, which may mask the pre-clinical efficacy of anti-obesity strategies that target energy expenditure (EE). Here, we quantified the impact of protonophore treatment on whole-body energetics in mice housed at 30°C.MethodsC5...

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Bibliographic Details
Main Authors: Daniel G. Sadler, Reid D. Landes, Lillie Treas, James Sikes, Craig Porter
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Physiology
Subjects:
protonophores
energy expenditure
thermoneutral
mitochondria
mouse models
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2024.1452986/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2024.1452986/full

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