Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases
Natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens rather than peptides. Due to their immunoregulatory properties, extensive work has been done to elucidate the immune functions of NKT cells in various immune contexts such as autoimmunity for more than two...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.979370/full |
| _version_ | 1818473125699911680 |
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| author | Sung Won Lee Hyun Jung Park Luc Van Kaer Seokmann Hong |
| author_facet | Sung Won Lee Hyun Jung Park Luc Van Kaer Seokmann Hong |
| author_sort | Sung Won Lee |
| collection | DOAJ |
| description | Natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens rather than peptides. Due to their immunoregulatory properties, extensive work has been done to elucidate the immune functions of NKT cells in various immune contexts such as autoimmunity for more than two decades. In addition, as research on barrier immunity such as the mucosa-associated lymphoid tissue has flourished in recent years, the role of NKT cells to immunity in the skin has attracted substantial attention. Here, we review the contributions of NKT cells to regulating skin inflammation and discuss the factors that can modulate the functions of NKT cells in inflammatory skin diseases such as atopic dermatitis. This mini-review article will mainly focus on CD1d-dependent NKT cells and their therapeutic potential in skin-related immune diseases. |
| first_indexed | 2024-04-14T04:17:43Z |
| format | Article |
| id | doaj.art-b3c61cac9ae047b9a8a848e13665c396 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T04:17:43Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b3c61cac9ae047b9a8a848e13665c3962022-12-22T02:12:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-09-011310.3389/fimmu.2022.979370979370Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseasesSung Won Lee0Hyun Jung Park1Luc Van Kaer2Seokmann Hong3Department of Integrative Bioscience and Biotechnology, Institute of Anticancer Medicine Development, Sejong University, Seoul, South KoreaDepartment of Integrative Bioscience and Biotechnology, Institute of Anticancer Medicine Development, Sejong University, Seoul, South KoreaDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United StatesDepartment of Integrative Bioscience and Biotechnology, Institute of Anticancer Medicine Development, Sejong University, Seoul, South KoreaNatural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens rather than peptides. Due to their immunoregulatory properties, extensive work has been done to elucidate the immune functions of NKT cells in various immune contexts such as autoimmunity for more than two decades. In addition, as research on barrier immunity such as the mucosa-associated lymphoid tissue has flourished in recent years, the role of NKT cells to immunity in the skin has attracted substantial attention. Here, we review the contributions of NKT cells to regulating skin inflammation and discuss the factors that can modulate the functions of NKT cells in inflammatory skin diseases such as atopic dermatitis. This mini-review article will mainly focus on CD1d-dependent NKT cells and their therapeutic potential in skin-related immune diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2022.979370/fullCD1d-restricted NKT cellsglycolipid antigensatopic dermatitisallergic contact dermatitispsoriasisUV-induced skin inflammation |
| spellingShingle | Sung Won Lee Hyun Jung Park Luc Van Kaer Seokmann Hong Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases Frontiers in Immunology CD1d-restricted NKT cells glycolipid antigens atopic dermatitis allergic contact dermatitis psoriasis UV-induced skin inflammation |
| title | Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases |
| title_full | Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases |
| title_fullStr | Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases |
| title_full_unstemmed | Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases |
| title_short | Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases |
| title_sort | roles and therapeutic potential of cd1d restricted nkt cells in inflammatory skin diseases |
| topic | CD1d-restricted NKT cells glycolipid antigens atopic dermatitis allergic contact dermatitis psoriasis UV-induced skin inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.979370/full |
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