Diagnosis of inflammatory myofibroblastic tumor in a pediatric patient initially suspected of tuberculosis
Abstract Background Symptoms of inflammatory myofibroblastic tumor (IMT) are atypical, and histopathological misdiagnosis of IMT is still inevitable. Here we present a pediatric case that an eight-year-old boy with recurrent fever for fifteen months, received anti-tuberculosis therapy for five month...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-023-04431-1 |
| _version_ | 1797451496657256448 |
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| author | Yiyuan Li Yang Wen |
| author_facet | Yiyuan Li Yang Wen |
| author_sort | Yiyuan Li |
| collection | DOAJ |
| description | Abstract Background Symptoms of inflammatory myofibroblastic tumor (IMT) are atypical, and histopathological misdiagnosis of IMT is still inevitable. Here we present a pediatric case that an eight-year-old boy with recurrent fever for fifteen months, received anti-tuberculosis therapy for five months and was ultimately confirmed to be IMT. Case presentation An eight-year-old boy experienced a recurrent fever for fifteen months, accompanied by cough, vomiting, meteorism, night sweating, and emaciation. Thoracoabdominal computer tomography revealed multiple enlarged lymph nodes in the thorax, abdomen, and axilla, as well as minimal bilateral pleural effusion. Histopathological examinations of the intestines and greater omentum implied fibrous tissue hyperplasia along with eosinophil and lymphocyte infiltration. The patient was initially misdiagnosed with tuberculosis, and symptoms were relieved partially following anti-tuberculosis treatment. However, after four months, the symptoms aggravated again and a subsequent histopathological analysis of a second sample from the greater omentum revealed the presence of IMT. Eventually, after surgical resection of the lesions and chemotherapy, the clinical symptoms in the child gradually alleviated. Conclusions The clinical course of IMT is variable, and pediatricians should pay attention to differentiating IMT from tuberculosis. |
| first_indexed | 2024-03-09T14:55:29Z |
| format | Article |
| id | doaj.art-b3c66218e24e41e6a198558ca3dd1506 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-03-09T14:55:29Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-b3c66218e24e41e6a198558ca3dd15062023-11-26T14:15:06ZengBMCBMC Pediatrics1471-24312023-11-012311510.1186/s12887-023-04431-1Diagnosis of inflammatory myofibroblastic tumor in a pediatric patient initially suspected of tuberculosisYiyuan Li0Yang Wen1Key Laboratory of Women and Children Diseases, department of pediatrics, West China Second University Hospital, Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Sichuan University, Ministry of EducationKey Laboratory of Women and Children Diseases, department of pediatrics, West China Second University Hospital, Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Sichuan University, Ministry of EducationAbstract Background Symptoms of inflammatory myofibroblastic tumor (IMT) are atypical, and histopathological misdiagnosis of IMT is still inevitable. Here we present a pediatric case that an eight-year-old boy with recurrent fever for fifteen months, received anti-tuberculosis therapy for five months and was ultimately confirmed to be IMT. Case presentation An eight-year-old boy experienced a recurrent fever for fifteen months, accompanied by cough, vomiting, meteorism, night sweating, and emaciation. Thoracoabdominal computer tomography revealed multiple enlarged lymph nodes in the thorax, abdomen, and axilla, as well as minimal bilateral pleural effusion. Histopathological examinations of the intestines and greater omentum implied fibrous tissue hyperplasia along with eosinophil and lymphocyte infiltration. The patient was initially misdiagnosed with tuberculosis, and symptoms were relieved partially following anti-tuberculosis treatment. However, after four months, the symptoms aggravated again and a subsequent histopathological analysis of a second sample from the greater omentum revealed the presence of IMT. Eventually, after surgical resection of the lesions and chemotherapy, the clinical symptoms in the child gradually alleviated. Conclusions The clinical course of IMT is variable, and pediatricians should pay attention to differentiating IMT from tuberculosis.https://doi.org/10.1186/s12887-023-04431-1Inflammatory myofibroblastic TumorTuberculosisPediatric |
| spellingShingle | Yiyuan Li Yang Wen Diagnosis of inflammatory myofibroblastic tumor in a pediatric patient initially suspected of tuberculosis BMC Pediatrics Inflammatory myofibroblastic Tumor Tuberculosis Pediatric |
| title | Diagnosis of inflammatory myofibroblastic tumor in a pediatric patient initially suspected of tuberculosis |
| title_full | Diagnosis of inflammatory myofibroblastic tumor in a pediatric patient initially suspected of tuberculosis |
| title_fullStr | Diagnosis of inflammatory myofibroblastic tumor in a pediatric patient initially suspected of tuberculosis |
| title_full_unstemmed | Diagnosis of inflammatory myofibroblastic tumor in a pediatric patient initially suspected of tuberculosis |
| title_short | Diagnosis of inflammatory myofibroblastic tumor in a pediatric patient initially suspected of tuberculosis |
| title_sort | diagnosis of inflammatory myofibroblastic tumor in a pediatric patient initially suspected of tuberculosis |
| topic | Inflammatory myofibroblastic Tumor Tuberculosis Pediatric |
| url | https://doi.org/10.1186/s12887-023-04431-1 |
| work_keys_str_mv | AT yiyuanli diagnosisofinflammatorymyofibroblastictumorinapediatricpatientinitiallysuspectedoftuberculosis AT yangwen diagnosisofinflammatorymyofibroblastictumorinapediatricpatientinitiallysuspectedoftuberculosis |