The tumor‐to‐liver ratio of the standardized uptake value is a useful FDG‐PET/CT parameter for predicting malignant intraductal papillary mucinous neoplasm of the pancreas
Abstract Background The present study aimed to investigate the efficacy of positron emission tomography with 18Fluoro‐deoxyglucose (FDG‐PET/CT) for predicting malignant intraductal papillary mucinous neoplasm (IPMN). Methods The records of 88 patients pathologically diagnosed with IPMN after surgery...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-09-01
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| Series: | Annals of Gastroenterological Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ags3.12562 |
| _version_ | 1811268374309634048 |
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| author | Takeshi Utsunomiya Kohei Ogawa Naotake Funamizu Katsunori Sakamoto Jota Watanabe Hiromi Otani Naoto Kawaguchi Masao Miyagawa Hirotaka Iwaki Yasutsugu Takada |
| author_facet | Takeshi Utsunomiya Kohei Ogawa Naotake Funamizu Katsunori Sakamoto Jota Watanabe Hiromi Otani Naoto Kawaguchi Masao Miyagawa Hirotaka Iwaki Yasutsugu Takada |
| author_sort | Takeshi Utsunomiya |
| collection | DOAJ |
| description | Abstract Background The present study aimed to investigate the efficacy of positron emission tomography with 18Fluoro‐deoxyglucose (FDG‐PET/CT) for predicting malignant intraductal papillary mucinous neoplasm (IPMN). Methods The records of 88 patients pathologically diagnosed with IPMN after surgery at Ehime University Hospital and Ehime Prefectural Central Hospital from April 2009 to December 2020 were retrospectively reviewed. The patients’ characteristics, blood chemistry, and imaging examinations were evaluated as potential predictors of malignant IPMN. Of the PET/CT results, the maximum standardized uptake value (SUVmax) of the tumor, the tumor‐to‐blood pool ratio of the SUV (TBR), and the tumor‐to‐liver ratio of the SUV (TLR) were compared. Results On pathology, the diagnosis was adenoma (IPMA) in 40 patients, high‐grade dysplasia (HGD) in 26 patients, and carcinoma (IPMC) in 22 patients. HGD and IPMC were defined as malignant IPMN. On multivariate analyses, TLR ≥ 1.3 and high‐risk stigmata were independent predictors of malignant IPMN (P = .001 and P = .007, respectively). When both HRS and TLR ≥ 1.3 were present, the positive predictive value for malignancy was 88.2%. Furthermore, TLR was significantly higher for patients with IPMC than with HGD (P = .039). Conclusion TLR can be a useful predictor for differentiating benign from malignant IPMN and may be associated with postoperative outcomes. |
| first_indexed | 2024-04-12T21:21:46Z |
| format | Article |
| id | doaj.art-b3c714a72e9344ac9e55544c936e1ba4 |
| institution | Directory Open Access Journal |
| issn | 2475-0328 |
| language | English |
| last_indexed | 2024-04-12T21:21:46Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Gastroenterological Surgery |
| spelling | doaj.art-b3c714a72e9344ac9e55544c936e1ba42022-12-22T03:16:17ZengWileyAnnals of Gastroenterological Surgery2475-03282022-09-016569570310.1002/ags3.12562The tumor‐to‐liver ratio of the standardized uptake value is a useful FDG‐PET/CT parameter for predicting malignant intraductal papillary mucinous neoplasm of the pancreasTakeshi Utsunomiya0Kohei Ogawa1Naotake Funamizu2Katsunori Sakamoto3Jota Watanabe4Hiromi Otani5Naoto Kawaguchi6Masao Miyagawa7Hirotaka Iwaki8Yasutsugu Takada9Department of Hepato‐Billiary‐Pancreatic Surgery Ehime University Hospital Ehime JapanDepartment of Hepato‐Billiary‐Pancreatic Surgery Ehime University Hospital Ehime JapanDepartment of Hepato‐Billiary‐Pancreatic Surgery Ehime University Hospital Ehime JapanDepartment of Hepato‐Billiary‐Pancreatic Surgery Ehime University Hospital Ehime JapanDepartment of Gastroenterological Surgery Ehime Prefectural Central Hospital Ehime JapanDepartment of Gastroenterological Surgery Ehime Prefectural Central Hospital Ehime JapanDepartment of Radiology Ehime University Graduate School of Medicine Ehime JapanDepartment of Radiology Ehime University Graduate School of Medicine Ehime JapanDepartment of Clinical Pharmacology and Therapeutics Ehime University Graduate School of Medicine Ehime JapanDepartment of Hepato‐Billiary‐Pancreatic Surgery Ehime University Hospital Ehime JapanAbstract Background The present study aimed to investigate the efficacy of positron emission tomography with 18Fluoro‐deoxyglucose (FDG‐PET/CT) for predicting malignant intraductal papillary mucinous neoplasm (IPMN). Methods The records of 88 patients pathologically diagnosed with IPMN after surgery at Ehime University Hospital and Ehime Prefectural Central Hospital from April 2009 to December 2020 were retrospectively reviewed. The patients’ characteristics, blood chemistry, and imaging examinations were evaluated as potential predictors of malignant IPMN. Of the PET/CT results, the maximum standardized uptake value (SUVmax) of the tumor, the tumor‐to‐blood pool ratio of the SUV (TBR), and the tumor‐to‐liver ratio of the SUV (TLR) were compared. Results On pathology, the diagnosis was adenoma (IPMA) in 40 patients, high‐grade dysplasia (HGD) in 26 patients, and carcinoma (IPMC) in 22 patients. HGD and IPMC were defined as malignant IPMN. On multivariate analyses, TLR ≥ 1.3 and high‐risk stigmata were independent predictors of malignant IPMN (P = .001 and P = .007, respectively). When both HRS and TLR ≥ 1.3 were present, the positive predictive value for malignancy was 88.2%. Furthermore, TLR was significantly higher for patients with IPMC than with HGD (P = .039). Conclusion TLR can be a useful predictor for differentiating benign from malignant IPMN and may be associated with postoperative outcomes.https://doi.org/10.1002/ags3.12562FDG‐PET/CThigh‐risk stigmataIPMNNLRSUV |
| spellingShingle | Takeshi Utsunomiya Kohei Ogawa Naotake Funamizu Katsunori Sakamoto Jota Watanabe Hiromi Otani Naoto Kawaguchi Masao Miyagawa Hirotaka Iwaki Yasutsugu Takada The tumor‐to‐liver ratio of the standardized uptake value is a useful FDG‐PET/CT parameter for predicting malignant intraductal papillary mucinous neoplasm of the pancreas Annals of Gastroenterological Surgery FDG‐PET/CT high‐risk stigmata IPMN NLR SUV |
| title | The tumor‐to‐liver ratio of the standardized uptake value is a useful FDG‐PET/CT parameter for predicting malignant intraductal papillary mucinous neoplasm of the pancreas |
| title_full | The tumor‐to‐liver ratio of the standardized uptake value is a useful FDG‐PET/CT parameter for predicting malignant intraductal papillary mucinous neoplasm of the pancreas |
| title_fullStr | The tumor‐to‐liver ratio of the standardized uptake value is a useful FDG‐PET/CT parameter for predicting malignant intraductal papillary mucinous neoplasm of the pancreas |
| title_full_unstemmed | The tumor‐to‐liver ratio of the standardized uptake value is a useful FDG‐PET/CT parameter for predicting malignant intraductal papillary mucinous neoplasm of the pancreas |
| title_short | The tumor‐to‐liver ratio of the standardized uptake value is a useful FDG‐PET/CT parameter for predicting malignant intraductal papillary mucinous neoplasm of the pancreas |
| title_sort | tumor to liver ratio of the standardized uptake value is a useful fdg pet ct parameter for predicting malignant intraductal papillary mucinous neoplasm of the pancreas |
| topic | FDG‐PET/CT high‐risk stigmata IPMN NLR SUV |
| url | https://doi.org/10.1002/ags3.12562 |
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