Age-Dependent Changes in the Effects of Androgens on Female Metabolic and Body Weight Regulation Systems in Humans and Laboratory Animals
In recent years, the effects of androgens on metabolic and body weight regulation systems and their underlying mechanisms have been gradually revealed in females. In women and experimental animals of reproductive age, androgen excess can adversely affect metabolic functioning, appetite, and body wei...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/23/16567 |
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| author | Takeshi Iwasa Hiroki Noguchi Risa Tanano Erika Yamanaka Asuka Takeda Kou Tamura Hidenori Aoki Tatsuro Sugimoto Hikari Sasada Takaaki Maeda Saki Minato Shota Yamamoto Hiroaki Inui Tomohiro Kagawa Atsuko Yoshida Ayuka Mineda Mari Nii Riyo Kinouchi Kanako Yoshida Yuri Yamamoto Takashi Kaji |
| author_facet | Takeshi Iwasa Hiroki Noguchi Risa Tanano Erika Yamanaka Asuka Takeda Kou Tamura Hidenori Aoki Tatsuro Sugimoto Hikari Sasada Takaaki Maeda Saki Minato Shota Yamamoto Hiroaki Inui Tomohiro Kagawa Atsuko Yoshida Ayuka Mineda Mari Nii Riyo Kinouchi Kanako Yoshida Yuri Yamamoto Takashi Kaji |
| author_sort | Takeshi Iwasa |
| collection | DOAJ |
| description | In recent years, the effects of androgens on metabolic and body weight regulation systems and their underlying mechanisms have been gradually revealed in females. In women and experimental animals of reproductive age, androgen excess can adversely affect metabolic functioning, appetite, and body weight regulation. In addition, excess androgens can increase the risk of metabolic disorders, such as obesity, insulin resistance, and diabetes. These unfavorable effects of androgens are induced by alterations in the actions of hypothalamic appetite-regulatory factors, reductions in energy expenditure, insulin resistance in skeletal muscle, and β-cell dysfunction. Interestingly, these unfavorable effects of androgens on metabolic and body-weight regulation systems are neither observed nor evident in ovariectomized animals and post-menopausal women, indicating that the adverse effects of androgens might be dependent on the estrogen milieu. Recent findings may provide novel sex- and age-specific strategies for treating metabolic diseases. |
| first_indexed | 2024-03-09T01:51:07Z |
| format | Article |
| id | doaj.art-b3c939a3a5834cba85fdc2ede6994cc8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T01:51:07Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b3c939a3a5834cba85fdc2ede6994cc82023-12-08T15:16:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-11-0124231656710.3390/ijms242316567Age-Dependent Changes in the Effects of Androgens on Female Metabolic and Body Weight Regulation Systems in Humans and Laboratory AnimalsTakeshi Iwasa0Hiroki Noguchi1Risa Tanano2Erika Yamanaka3Asuka Takeda4Kou Tamura5Hidenori Aoki6Tatsuro Sugimoto7Hikari Sasada8Takaaki Maeda9Saki Minato10Shota Yamamoto11Hiroaki Inui12Tomohiro Kagawa13Atsuko Yoshida14Ayuka Mineda15Mari Nii16Riyo Kinouchi17Kanako Yoshida18Yuri Yamamoto19Takashi Kaji20Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanDepartment of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, JapanIn recent years, the effects of androgens on metabolic and body weight regulation systems and their underlying mechanisms have been gradually revealed in females. In women and experimental animals of reproductive age, androgen excess can adversely affect metabolic functioning, appetite, and body weight regulation. In addition, excess androgens can increase the risk of metabolic disorders, such as obesity, insulin resistance, and diabetes. These unfavorable effects of androgens are induced by alterations in the actions of hypothalamic appetite-regulatory factors, reductions in energy expenditure, insulin resistance in skeletal muscle, and β-cell dysfunction. Interestingly, these unfavorable effects of androgens on metabolic and body-weight regulation systems are neither observed nor evident in ovariectomized animals and post-menopausal women, indicating that the adverse effects of androgens might be dependent on the estrogen milieu. Recent findings may provide novel sex- and age-specific strategies for treating metabolic diseases.https://www.mdpi.com/1422-0067/24/23/16567androgenestrogenPCOShypothalamus |
| spellingShingle | Takeshi Iwasa Hiroki Noguchi Risa Tanano Erika Yamanaka Asuka Takeda Kou Tamura Hidenori Aoki Tatsuro Sugimoto Hikari Sasada Takaaki Maeda Saki Minato Shota Yamamoto Hiroaki Inui Tomohiro Kagawa Atsuko Yoshida Ayuka Mineda Mari Nii Riyo Kinouchi Kanako Yoshida Yuri Yamamoto Takashi Kaji Age-Dependent Changes in the Effects of Androgens on Female Metabolic and Body Weight Regulation Systems in Humans and Laboratory Animals International Journal of Molecular Sciences androgen estrogen PCOS hypothalamus |
| title | Age-Dependent Changes in the Effects of Androgens on Female Metabolic and Body Weight Regulation Systems in Humans and Laboratory Animals |
| title_full | Age-Dependent Changes in the Effects of Androgens on Female Metabolic and Body Weight Regulation Systems in Humans and Laboratory Animals |
| title_fullStr | Age-Dependent Changes in the Effects of Androgens on Female Metabolic and Body Weight Regulation Systems in Humans and Laboratory Animals |
| title_full_unstemmed | Age-Dependent Changes in the Effects of Androgens on Female Metabolic and Body Weight Regulation Systems in Humans and Laboratory Animals |
| title_short | Age-Dependent Changes in the Effects of Androgens on Female Metabolic and Body Weight Regulation Systems in Humans and Laboratory Animals |
| title_sort | age dependent changes in the effects of androgens on female metabolic and body weight regulation systems in humans and laboratory animals |
| topic | androgen estrogen PCOS hypothalamus |
| url | https://www.mdpi.com/1422-0067/24/23/16567 |
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