The crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer
Ferroptosis is an iron-dependent cell death process characterized by excessive accumulation of reactive oxygen species and lipid peroxidation. The elucidation of ferroptosis pathways may lead to novel cancer therapies. Current evidence suggests that the mechanism of ferroptosis can be summarized as...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.916082/full |
| _version_ | 1828439067044347904 |
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| author | Kun Ke Kun Ke Li Li Li Li Chao Lu Qicong Zhu Yuanyu Wang Yiping Mou Yiping Mou Huiju Wang Huiju Wang Weiwei Jin Weiwei Jin |
| author_facet | Kun Ke Kun Ke Li Li Li Li Chao Lu Qicong Zhu Yuanyu Wang Yiping Mou Yiping Mou Huiju Wang Huiju Wang Weiwei Jin Weiwei Jin |
| author_sort | Kun Ke |
| collection | DOAJ |
| description | Ferroptosis is an iron-dependent cell death process characterized by excessive accumulation of reactive oxygen species and lipid peroxidation. The elucidation of ferroptosis pathways may lead to novel cancer therapies. Current evidence suggests that the mechanism of ferroptosis can be summarized as oxidative stress and antioxidant defense mechanisms. During this process, ferrous ions play a crucial role in cellular oxidation, plasma membrane damage, reactive oxygen species removal imbalance and lipid peroxidation. Although, disregulation of intracellular cations (Fe2+, Ca2+, Zn2+, etc.) and anions (Cl-, etc.) have been widely reported to be involved in ferroptosis, their specific regulatory mechanisms have not been established. To further understand the crosstalk effect between ferrous and other ions in ferroptosis, we reviewed the ferroptosis process from the perspective of ions metabolism. In addition, the role of ferrous and other ions in tumor therapy is briefly summarized. |
| first_indexed | 2024-12-10T20:17:02Z |
| format | Article |
| id | doaj.art-b3c9fef7b80d4827aea4aeddb622c5b4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-10T20:17:02Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b3c9fef7b80d4827aea4aeddb622c5b42022-12-22T01:35:10ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-08-011210.3389/fonc.2022.916082916082The crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancerKun Ke0Kun Ke1Li Li2Li Li3Chao Lu4Qicong Zhu5Yuanyu Wang6Yiping Mou7Yiping Mou8Huiju Wang9Huiju Wang10Weiwei Jin11Weiwei Jin12General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaKey Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, ChinaKey Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, ChinaClinical Research Institute, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, ChinaGeneral Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaGeneral Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaGeneral Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaGeneral Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaKey Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, ChinaKey Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, ChinaClinical Research Institute, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, ChinaGeneral Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaKey Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, ChinaFerroptosis is an iron-dependent cell death process characterized by excessive accumulation of reactive oxygen species and lipid peroxidation. The elucidation of ferroptosis pathways may lead to novel cancer therapies. Current evidence suggests that the mechanism of ferroptosis can be summarized as oxidative stress and antioxidant defense mechanisms. During this process, ferrous ions play a crucial role in cellular oxidation, plasma membrane damage, reactive oxygen species removal imbalance and lipid peroxidation. Although, disregulation of intracellular cations (Fe2+, Ca2+, Zn2+, etc.) and anions (Cl-, etc.) have been widely reported to be involved in ferroptosis, their specific regulatory mechanisms have not been established. To further understand the crosstalk effect between ferrous and other ions in ferroptosis, we reviewed the ferroptosis process from the perspective of ions metabolism. In addition, the role of ferrous and other ions in tumor therapy is briefly summarized.https://www.frontiersin.org/articles/10.3389/fonc.2022.916082/fullion metabolismferroptosisglutathione metabolismlipid peroxidationcancer therapy |
| spellingShingle | Kun Ke Kun Ke Li Li Li Li Chao Lu Qicong Zhu Yuanyu Wang Yiping Mou Yiping Mou Huiju Wang Huiju Wang Weiwei Jin Weiwei Jin The crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer Frontiers in Oncology ion metabolism ferroptosis glutathione metabolism lipid peroxidation cancer therapy |
| title | The crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer |
| title_full | The crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer |
| title_fullStr | The crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer |
| title_full_unstemmed | The crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer |
| title_short | The crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer |
| title_sort | crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer |
| topic | ion metabolism ferroptosis glutathione metabolism lipid peroxidation cancer therapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.916082/full |
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